3-pyridinecarboxaldehyde, 5-chloro-2-fluoro-

3-Pyridyl formaldehyde, 5-chloro-2-fluorine, this substance has a wide range of uses. In the field of medicinal chemistry, it can be a key intermediate and assist in the synthesis of many specific drugs. Due to its unique chemical structure, it can cleverly react with a variety of compounds to build complex molecules with specific biological activities.
In the field of materials science, it may be used to prepare materials with special properties. The specific functional groups in its structure may give the material unique optical, electrical or mechanical properties, such as improving the conductivity of the material and enhancing its fluorescence properties.
In the field of organic synthesis, it also plays an important role. With its activity check point, it can participate in various organic reactions, such as nucleophilic addition, condensation and other reactions, opening up a path for the synthesis of novel organic compounds and expanding the types and applications of organic compounds.
In the research and development of pesticides, it also has potential value. Or it can be used as a starting material, through a series of reactions, to produce pesticides with high efficiency in the control of specific pests, to help agricultural pest control and ensure crop harvest. In short, this substance has important uses in many fields, providing important support for related scientific research and industrial development.

3-Pyridine formaldehyde, 5-chloro-2-fluorine, is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, with pure color and no obvious variegation. This is due to the characteristics of the molecular structure, and there are not too many chromogenic groups. Its smell may have a special aromatic smell, but its taste is not strong and relatively mild, which is also determined by the composition and structure of its molecules.
Talking about the melting point and boiling point, the melting point is between -10 ° C and -5 ° C, and the boiling point is about 220 ° C to 230 ° C. The melting point is low, and it is difficult to maintain the solid state at a relatively high temperature due to the non-extremely strong intermolecular force; the boiling point is high, due to the existence of certain hydrogen bonds and van der Waals forces between molecules, more energy is required to overcome them and vaporize them.
Its density is about 1.35g/cm ³, which is heavier than water. This is due to the type and quantity of atoms in the molecule, resulting in a larger mass per unit volume. In terms of solubility, it can be well dissolved in common organic solvents such as ethanol and ether. Due to the principle of "similar miscibility", its molecular structure has similar polar or non-polar characteristics to that of organic solvents. However, its solubility in water is relatively small, because its molecular polarity does not match exactly with water. < Br >
Its volatility is weak, and at room temperature, the rate of molecular escape from the liquid surface is low, which is related to the intermolecular force and boiling point. The strong force and the higher boiling point make the molecule less volatile. The stability is acceptable. Under general environmental conditions, if there are no specific chemical reaction conditions such as high temperature, strong acid and base, strong oxidant, etc., the molecular structure can remain relatively stable.

The chemical synthesis of 5-chloro-2-fluoro-3-pyridine-formaldehyde is a key issue in the field of organic synthesis. Its synthesis method often relies on the ingenious combination of various organic reactions.
Initially, it can be started from a suitable pyridine derivative. Or choose a pyridine with a specific substituent and introduce chlorine and fluorine atoms by halogenation reaction. For example, take 2-hydroxy-3-methylpyridine as an example, first use a suitable halogenation reagent, such as a halogenating agent containing chlorine and fluorine, under specific reaction conditions, such as appropriate temperature and the presence of a catalyst. Halogenation is carried out. The temperature may be controlled at 50-80 degrees Celsius, and the catalyst may use Lewis acid to replace the hydroxyl group with chlorine and fluorine to obtain 5-chloro-2-fluoro-3-methylpyridine.
Second, the methyl group is converted to an aldehyde group. A mild oxidation method can be used, such as manganese dioxide-sulfuric acid system, at a moderate temperature, about 30-50 degrees Celsius, to oxidize the methyl group to an aldehyde group. This process requires fine control of the reaction conditions to prevent excessive oxidation from further converting the aldehyde group into a carboxyl group.
Or there is another method. Chlorine, fluorine and aldehyde-related precursors can be introduced from the beginning of the construction of the pyridine ring. The pyridine ring is formed by cyclization of small molecules containing suitable nitrogen, carbon and halogen atoms as raw materials. For example, the β-dicarbonyl compound containing chlorine and fluorine is combined with ammonia or amine under acidic catalysis, through condensation, cyclization, one-step or multi-step reaction, the pyridine ring is constructed and the desired substituent is introduced at the same time. The reaction solvent or alcohol or polar aprotic solvent, the reaction temperature varies according to the specific reaction step, or between room temperature and 120 degrees Celsius.
Synthesis of 5-chloro-2-fluoro-3-pyridyl formaldehyde requires careful selection of an appropriate synthesis path depending on factors such as the availability of raw materials, the difficulty of controlling reaction conditions, and cost. This target product can only be obtained through multiple steps of delicate reactions.

I have not heard the market price of "3 - pyridinecarboxaldehyde, 5 - chloro - 2 - fluoro -". This is a fine chemical raw material or an organic synthesis intermediate, and its price often varies depending on purity, supply and demand, origin and market conditions.
If you want the price, you should consult the chemical raw material supplier, chemical reagent seller, or find it on the chemical product trading platform. And this compound may have different purity specifications. The price of high purity is high, and the price of low purity is low.
And market supply and demand are also the main reasons. If there are many applicants and there are few suppliers, the price will rise; if the supply exceeds the demand, the price may fall. The origin is different, the cost is different, and the price is also different.
Therefore, if you want to know the exact price, you should visit the merchant in person, or check it in detail on the relevant platform before you can get it.

3-Pyridyl formaldehyde, 5-chloro-2-fluorine This is a matter of safety and must be treated with caution.
This compound should be protected first during experimental operation. Because it may be irritating, it can cause discomfort when in contact with the skin, eyes and respiratory tract. When operating, when fully armed, wearing laboratory clothes, wearing tight protective gloves, and the eyes should also be fully protected with goggles to ensure that there is no risk of exposure, so as to avoid inadvertent contamination and adverse consequences.
Ventilation is also crucial. The relevant operation should be carried out in a well-ventilated place, preferably in a fume hood. If the ventilation is not smooth, the accumulation of volatile gaseous substances will not only harm the health of the experimenter, but also pose a safety hazard.
Furthermore, when storing, it should also be paid attention to. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Due to its active chemical nature, improper storage or dangerous occurrence. Separate from other chemicals to prevent mutual reaction and harm and safety.
During the use process, precise operation is the key. According to the needs of the experiment, use an accurate measuring tool to take the appropriate amount to avoid waste, and more importantly, to prevent excessive accidents. After use, properly dispose of the remaining materials, do not discard them at will, and properly dispose of them in accordance with relevant regulations to prevent environmental pollution and endanger the ecology.
During transportation, do not take it lightly. Follow relevant regulations and use proper packaging to ensure stable transportation and avoid package damage due to bumps and collisions, which may lead to leakage.
In short, treat 3-pyridyl formaldehyde and 5-chloro-2-fluorine with rigor from operation, storage to transportation, and do not slack at all to ensure safety.