3-pyridinecarbonyl chloride, 2,6-dichloro-5-fluoro-

3-Aminopropionitrile, 2,6-dinitrile-5-aldehyde, is involved in "Tiangong Kaiwu", which is mostly related to chemical raw materials and intermediate products.
View "Tiangong Kaiwu", in which various methods of creation are detailed. In the field of chemical technology, the selection of raw materials is the key. This 3-aminopropionitrile, 2,6-dinitrile-5-aldehyde substance, or an important component in the preparation of special fabric dyes. The ancient art of dyeing and weaving pursues a bright and long-lasting color. Such nitrile and aldehyde compounds can be converted into stable dyes through ingenious chemical reactions.
Furthermore, it may also have a place in the preparation of metallurgical auxiliary agents. In metallurgy, additives are often needed to improve metal properties and remove impurities for purification. Substances such as 3-aminopropionitrile may react with metal impurities, helping to separate impurities and improve metal purity and quality.
And in the production of some special adhesives, such compounds may participate in reactions to adjust the adhesion and curing speed of adhesives. In ancient times, construction, woodworking and other industries had a great demand for adhesives, and their performance was related to the stability and durability of objects.
In the auxiliary link of pharmaceutical processing, although "Tiangong Kaiwu" is not detailed, it is analogous to the connection between chemistry and medicine in later generations, and it may play a role in purifying pharmaceutical ingredients and changing pharmaceutical dosage forms to achieve better medicinal effects.

3-To its methyl ether hydrazine, 2,6-dihydrazine-5-ether This material has different properties. Its light weight, if it floats in water, it is as smooth as fat to the touch. The color is pure and transparent, without variegated colors. It looks like a crystal of ice, but it is not as cold as ice.
Smell it, the gas is light and light, not pungent but attracting attention. When it burns, the flame is blue, quiet and bright, without the disturbance of thick smoke, and there is no filthy odor. When it burns, it releases heat quite steadily, and can be used for various purposes, such as cooking and heating.
Dissolved in various liquids, soluble in alcohols, mixed and uniform, like the fusion of water and milk; slightly soluble in water, like a flat floating in a pool, difficult to form a whole. Its chemical properties are also alive, and it is easy to change when encountering strong oxygen agents, or burn or explode, so be careful to deal with it. In contact with alkalis, the onset is slow, and the new material is different in nature. With its heterogeneity, it is widely available in the field of industry and technology. When making a drug, it can be used as an adjuvant to help the development of medicine; when making a fire, it can also be used as a material to increase its strength and stabilize its combustion. However, because of its activity, it is necessary to store and transport it according to regulations to prevent it from changing, so as to keep it safe.

The chemical properties of 3-alkylpyridine and 2,6-dichloro-5-fluorine are quite complicated, so let me tell you one by one.
In this compound, the pyridine ring is aromatic, and its nitrogen atom is electron-rich, which makes the pyridine ring prone to electrophilic substitution. Because the electronegativity of nitrogen atom is higher than that of carbon, the electron cloud distribution on the ring is uneven, so that the electrophilic substitution activity of the pyridine ring is lower than that of benzene, and the substitution check point is mostly at the β-position (3-position and 5-position), and the reaction intermediate is stable.
However, the substituents of 2,6-dichloro-5-fluorine have a great influence on the electron cloud distribution of the pyridine ring. Both chlorine and fluorine atoms have electron-sucking induction effects, which further reduce the electron cloud density of the pyridine ring, and make it more difficult for electrophilic substitution reactions to occur. However, the electron-sucking conjugation effect of fluorine atoms is relatively weak, while the conjugation effect of chlorine atoms is slightly stronger. These differences also affect the reactivity and selectivity of compounds.
In terms of nucleophilic substitution reactions, the activity of chlorine atoms at 2,6-positions is enhanced due to the reduction of the electron cloud density of the pyridine ring and the electron-sucking effect of the adjacent fluorine atoms. It is easy to attack nucleoph Although fluorine atoms have high electronegativity, their C-F bond energy is large, and their substitution activity is usually lower than that of chlorine atoms. However, under certain conditions, such as strong nucleophiles and high temperatures, fluorine atoms can also participate in nucleophilic substitution reactions.
In addition, this compound may also be involved in redox reactions. Pyridine rings can be oxidized by appropriate oxidants to form products such as pyridine-N-oxides, which change their electron cloud distribution and reactivity. In terms of reduction reactions, pyridine rings can undergo hydroreduction and other reactions under the action of specific reducing agents, and transform into corresponding saturated heterocyclic compounds.
Its physical properties cannot be ignored. Due to the presence of halogen atoms such as chlorine and fluorine, the polarity of the compound is enhanced, the relative molecular weight is increased, and the melting point and boiling point may be higher than that of simple pyridine derivatives. In solubility, due to the existence of polar groups, the solubility in polar solvents such as alcohols and ketones may be better than that of non-polar solvents. And the halogen atoms make it have a certain lipid solubility, and its transport and distribution in organisms may be affected.

To prepare 3-alkylbenzoic acid, 2,6-dibromo-5-bromo, the method is as follows:
First take an appropriate aromatic hydrocarbon substrate and introduce bromine atoms in a halogenation reaction. Liquid bromine is often used as the bromine source. Under the action of suitable catalysts such as iron filings or iron tribromide, aromatics can be brominated, and bromine atoms can be introduced at specific positions to obtain 2,6-dibromo aromatic intermediates. This reaction requires temperature control, attention to the feeding sequence, and prevention of excessive side reactions.
Subsequently, the bromine-containing intermediate is alkylated. Select a suitable alkylation reagent, such as halogenated alkanes, and react in an inert solvent such as dichloromethane or nitrobenzene with Lewis acid such as anhydrous aluminum trichloride as a catalyst. Alkyl groups can be introduced at specific positions on aromatics to form 2,6-dibromo-5-alkylaromatics.
Then this product is carboxylated to obtain the target product 3-alkylbenzoic acid. Generally, magnesium metal is reacted with 2,6-dibromo-5-alkylaromatics in anhydrous ethyl ether to obtain Grignard reagent. After that, Grignard reagent is passed into carbon dioxide gas and hydrolyzed to obtain 3-alkylbenzoic acid. < Br >
Each step of the reaction must strictly control the reaction conditions, such as temperature, reagent dosage, reaction time, etc., and separate and purify the product in time to improve the yield and purity of the reaction and achieve the purpose of preparation.

The market prices of 3-aminobenzonitrile and 2,6-dinitrile-5-aldehyde vary depending on market conditions, quality, and supply and demand.
Its market price, if it is a normal grade, 3-aminobenzonitrile per kilogram or between 100 gold and hundreds of gold. This is due to the difficulty of preparation and the cost of materials, so the price is not light. The preparation of 2,6-dinitrile-5-aldehyde is particularly difficult, and the use is specific, so its price is high, or around hundreds of gold to thousands of gold per kilogram.
If the quality is better, it is a high-purity product, used in fine chemical industry, pharmaceutical research and development and other important tasks, the price of 3-aminobenzonitrile per kilogram or over thousands of gold. The price of 2,6-dinitrile-5-aldehyde per kilogram may reach thousands of gold due to the need for high-quality purification methods and energy-consuming consumables.
Furthermore, the market supply and demand situation is also the key to the price. If there are many people who want it, and there are few people who supply it, the price will increase; if the supply exceeds the demand, the price will be reduced. And in different places, due to differences in logistics and taxes, the price is also different. Merchants sell it, mostly according to the times, and adjust the price according to the market conditions. Therefore, if you want to know the exact price, you need to consult the merchants of chemical materials, or check the report of the chemical market conditions, before you can get the actual price.