3-Pyridinecarbonitrile

3-Pyridoxonitrile, also known as nicotinitrile, is a crucial raw material in organic synthesis and is widely used in many fields.
First, in the field of pharmaceutical synthesis, it has a significant role. It can be used as a key intermediate for the preparation of a variety of drugs. For example, many bioactive compounds, the synthesis process often uses 3-pyridoxonitrile as the starting material. With the help of specific chemical reactions, its structure is modified and transformed to obtain pharmaceutical components with therapeutic effects. Like some cardiovascular disease treatment drugs and antimicrobial drugs, 3-pyridoxonitrile plays an indispensable role in the synthesis of drugs and makes great contributions to human health.
Second, in the field of pesticides, it also plays an important role. Based on it, a variety of high-efficiency pesticides can be synthesized. Such pesticides can effectively control crop diseases and pests, ensure the healthy growth of crops, and improve crop yield and quality. Due to its unique chemical structure, the synthesized pesticides have good biological activity and stability, and play an important protective role in agricultural production.
Third, in the field of materials science, 3-pyridineformonitrile is also useful. It can participate in the preparation of functional materials. By polymerizing with other compounds, etc., materials with special properties, such as some optoelectronic materials, are generated. These materials show unique advantages in electronic devices, optical devices, etc., and promote the continuous development of the field of materials science.
In summary, 3-pyridinitrile is an important basic raw material in many fields such as medicine, pesticides, and materials science, and plays a positive role in promoting the development of various fields.

3-Pyridineformonitrile, also known as nicotinitrile, has the following physical properties:
This substance is a white to pale yellow crystalline solid at room temperature, and it looks quite textured. The melting point is between 50 and 52 ° C, just like the cold temperature of winter. Within this temperature limit, its inherent form is stable. The boiling point reaches 203-204 ° C. When the temperature rises to this point, the substance will undergo a wonderful transformation from liquid to gaseous state.
Its density is about 1.129 g/cm ³, which is like a stable stone, occupying a specific density share in space. In terms of solubility, it is slightly soluble in water, but it can blend well in organic solvents such as ethanol and ether, just like a wanderer finding a suitable home and dispersing in the arms of these organic solvents.
3-pyridineformonitrile has a certain volatility and slowly emits its own breath in the air. Its vapor pressure has a corresponding value under specific conditions, reflecting the degree of its volatilization tendency. And because of its solid form, the texture is relatively stable, which is easy to store and transport. As long as it is placed under suitable environmental conditions, it can maintain its inherent physical properties for a long time, so that it can be used in various chemical fields.

3-Pyridyl formonitrile, also known as nicotinitrile, is an important raw material for organic synthesis and is widely used in many fields such as medicine, pesticides, dyes, etc. It has specific chemical properties, which are described as follows:
Looking at its structure, 3-pyridyl formonitrile contains a pyridyl ring and a cyano group. The pyridyl ring is a six-membered heterocyclic ring with aromatic properties and a special electron cloud distribution, which makes the chemical activity of the compound unique. The presence of cyano (-CN) increases its reactivity and unique chemical properties.
In terms of physical properties, 3-pyridyl formonitrile is a white to pale yellow crystalline solid under normal conditions, with a certain melting point and boiling point. The melting point is about 50-53 ° C, and the boiling point is about 201-202 ° C. Due to the existence of certain forces between molecules, its structure is stable in the solid state. Slightly soluble in water, but soluble in organic solvents such as ethanol, ether, and chloroform. This solubility is related to the polarity of the molecule. The pyridine ring and the cyanyl group make the molecule have a certain polarity, but the polarity is not enough to make it fully miscible with water.
When it comes to chemical properties, the cyanyl group has a high activity. First, hydrolysis can occur. Under the condition of acid or base catalysis, the cyanyl group is gradually converted into carboxyl groups. If in an acidic environment, it is hydrolyzed into an amide intermediate, and then converted into 3-pyridinecarboxylic acid This reaction is an important way to prepare pyridine carboxylic acids. Second, the reduction reaction can be carried out. With a suitable reducing agent, the cyano group can be reduced to an amine group to obtain 3-pyridylmethylamine. This reaction is used in organic synthesis to construct nitrogen-containing functional groups. Third, the pyridine ring also participates in the reaction. Because of its aromatic properties, electrophilic substitution reactions can occur. However, compared with benzene, the electron cloud density of the pyridine ring is lower, and the electrophilic substitution activity is slightly inferior. Substitution reactions mostly occur at the β-position of the pyridine ring (relative to the cyano group), because the electron cloud density at this position is relatively high. The chemical properties of 3-pyridinecarbonitrile make it an extremely valuable building block in organic synthesis, providing an effective path for the preparation of many organic compounds.

The synthesis method of 3-pyridinitrile has existed in ancient times, and with the passage of time, the methods have become more and more diverse. In the past, pyridine was often used as the base, and the halogenation method was used to halogenate the pyridine at a specific position, and then the cyanyl group was substituted for the halogen atom. Although this method can prepare 3-pyridinitrile, the steps are complicated and the yield is unsatisfactory.
There are also nitrogen-containing heterocyclic compounds as the starting material, which are converted by multi-step reaction. For example, a specific nitrogen-containing heterocyclic ring is first cyclized to form the prototype of the pyridine ring, and then a cyanyl group is introduced at a specific position of the pyridine ring. Although this approach is innovative, the reaction conditions are harsh, and the requirements for reaction equipment and operation are quite high.
Later generations have used transition metal catalysis. A suitable transition metal catalyst is selected, and a specific ligand is matched to couple the cyanide-containing reagent with the pyridine derivative. This method has relatively mild reaction conditions, good selectivity, and considerable yield. It has gradually become the mainstream method for the synthesis of 3-pyridineformonitrile.
In addition, there is also the exploration of photocatalytic synthesis. The active species generated by photocatalysts excited by light are used to promote the free radical reaction of the reactants and realize the conversion to 3-pyridineformonitrile. This photocatalytic method is green and environmentally friendly, and the reaction conditions are mild. Although it is still in the research stage, it has broad prospects and is expected to open up a new path for the synthesis of 3-pyridinonitrile.

3-Pyridyl formonitrile, in the market price range, it is difficult to set quickly. Its price often changes due to various reasons, such as quality, quantity, current conditions, and supply and demand conditions.
If the quality is high, and the purchase volume is quite large, or due to the scale effect, the unit price can be slightly reduced. However, the quality is poor, or the purchase quantity is very small, and the price may increase. In terms of current conditions, if the raw materials are easily available and the production is smooth, the price may be stable and decline; if the raw materials are scarce and the production is difficult, the price will be easy to rise.
Looking at the past market state, its price fluctuations do not exist. In the past, due to the high yield of a certain raw material, the output of 3-pyridineformonitrile increased, and the price fell. Later, due to stricter environmental regulations, some manufacturers stopped production, supply decreased, and prices rose again.
Generally speaking, the price may fluctuate between tens of yuan and hundreds of yuan per kilogram. However, this is only a rough estimate. To know the accurate price, you need to consult chemical raw material suppliers and distributors, and carefully examine their quotations. According to the current market conditions, you can obtain a certain number.