3-pyridineacetic acid

3-Pyridyl acetic acid has a variety of properties. This substance is an organic compound, in the shape of white to off-white crystalline powder, which is relatively stable at room temperature and pressure.
Its solubility is soluble in polar solvents such as water and alcohols. This characteristic is due to the fact that its molecular structure contains polar groups and can form hydrogen bonds with polar solvents.
3-Pyridyl acetic acid is acidic because the carboxyl group can ionize hydrogen ions. In chemical reactions, the carboxyl group can participate in many reactions, such as esterification with alcohols to form esters, or neutralization with bases to form salts. The pyridine ring also has unique reactivity and can undergo electrophilic substitution reaction. Due to the aromaticity of the pyridine ring, the electron cloud distribution is special, and the nitrogen atom affects the electron density on the ring, making the specific position more vulnerable to electrophilic reagents.
In the field of organic synthesis, 3-pyridyl acetic acid is an important intermediate, which can construct complex organic molecular structures through various reaction paths, which can be used to create compounds such as drugs and pesticides. In drug development, its structure can be modified to obtain compounds with specific biological activities and pharmacological properties.

3-Pyridyl acetic acid is one of the most important compounds in the field of organic compounds. It has a wide range of uses and plays a key role in many fields.
In the field of medicine, this compound has shown unique value. Due to the special structure of the pyridyl ring and the acetic acid group, it has potential biological activity. Studies have shown that it can act as a pharmaceutical intermediate and help synthesize a variety of drugs. For example, some drugs used in the treatment of cardiovascular diseases, 3-pyridyl acetic acid participates in the synthesis process, which is of great significance for drug structure modification and activity adjustment, and provides a key basis for the development of therapeutic drugs for cardiovascular diseases.
In the field of materials science, 3-pyridyl acetic acid also plays an important role. Due to its structural properties, it can be used to prepare specific For example, in the synthesis of polymer materials, it participates in the polymerization reaction as a functional monomer, endowing the material with special properties, such as improving material solubility and improving material stability, opening up new paths for the development of new high-performance materials.
In addition, in the field of organic synthetic chemistry, 3-pyridyl acetic acid is a commonly used synthetic building block. With its active chemical properties, it can participate in many organic reactions, such as esterification reactions, amidation reactions, etc. Through these reactions, complex organic molecular structures can be constructed, providing organic synthesis chemists with rich synthesis strategies, promoting the continuous development of organic synthesis chemistry, and helping to create more organic compounds with unique properties and functions.

The synthesis methods of 3-pyridyl acetic acid have existed in ancient times, and there are many kinds. One method is to take pyridine as the initial substance, and introduce the acetyl group through the reaction of acylation. First, pyridine and acetic anhydride are heated under suitable conditions. With sulfuric acid or other acids as catalysts, the nitrogen atom of pyridine nucleophilically attacks the carbonyl carbon of acetic anhydride, and then forms an intermediate. After hydrolysis, pyridine derivatives containing acetyl groups can be obtained. The derivative is then oxidized under specific conditions, and the acetyl group is converted into a carboxyl group to obtain 3-pyridyl acetic acid.
There are also those who use 3-methylpyridine as the starting material. First, the methyl group of 3-methylpyridine is oxidized to a carboxyl group in an alkaline environment with a suitable oxidizing agent, such as potassium permanganate or potassium dichromate, to obtain 3-pyridinecarboxylic acid. Then, 3-pyridinecarboxylic acid reacts with halogenated acetate under basic conditions, such as in an alcoholic solution of sodium alcohol, the carboxyl negative ion of 3-pyridinecarboxylic acid nucleophilically attacks the α-carbon of the halogenated acetate to form a new carbon-carbon bond. After hydrolysis and acidification, 3-pyridinecarboxylic acid can also be obtained.
In addition, it can be synthesized by a reaction involving organometallic reagents. With 3-bromopyridine as the starting material, the Grignard reagent, that is, 3-pyridyl magnesium bromide, is first reacted with magnesium. Then, the Grignard reagent undergoes nucleophilic addition reaction with acetoxylate, and the obtained product is hydrolyzed and acidified to remove the protective group, and 3-pyridyl acetic acid can also be prepared. This method has its own advantages and disadvantages, and it needs to be selected according to the actual needs and conditions.

The price of 3-pyridyl acetic acid varies from market to market due to differences in quality, quantity, and source.
If its quality is pure and wide, or it comes from a well-known factory, with fine craftsmanship and high quality, the price will be very high. Its price can often reach tens of gold per gram, so this is the price of the superior.
If the quality is slightly inferior, or the quantity is small, and it comes from ordinary workshops, although it can be used, the price will be slightly reduced. It can be more than ten gold per gram.
There are also those whose price varies according to the supply and demand of the market. If there are many people who need it at the moment, and there are few people who supply it, the price will tend to rise; if the supply exceeds the demand, the price may fluctuate.
As for the exact value, it is difficult to generalize. The market situation is fickle. It is necessary to carefully observe the current price and consult the cities to know the approximate price range. The price per gram is usually between a few gold and a few tens of gold. This is only an approximate number and cannot be determined.

3-Pyridyl acetic acid has relatively stable properties, but in order to ensure its quality remains unchanged, it must comply with specific regulations.
First, it should be placed in a cool place. Cover high temperature can promote its chemical changes, causing the risk of deterioration. On a hot day, if exposed to the hot sun, or near the source of a hot topic, its molecular structure may change, reduce its effectiveness and damage its quality. Therefore, it is better to hide in a dark and cool place, so that the temperature is always kept below 25 ° C.
Second, a dry place is better. This product is easy to deliquescent in contact with water, moisture invades it, or hydrolysis reactions, and its purity is damaged. If it is stored in a storage place, it must be rainproof, and the air humidity should be controlled below 60%. A desiccant can be placed next to it to absorb moisture.
Third, it should be sealed and stored. If exposed to the air, or in contact with oxygen, carbon dioxide and other gases, it will cause oxidation, carbonation and other changes. When stored in an airtight container, it should be sealed immediately after use, and air should be kept out.
Fourth, keep away from fire sources and oxidants. This substance is flammable to a certain extent, and near fire is dangerous; and oxidants can react violently with it, endangering safety. It must be separated from fire candles and strong oxidants and stored in a safe place. < Br >
Hidden 3-pyridyl acetic acid, keep this cool, dry, sealed and protected from fire and oxidants to ensure its stability and integrity.