3-nitro-5-aminopyridine

3-Nitro-5-aminopyridine, or 3-nitro-5-aminopyridine, is widely used. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many drugs. Due to its pyridine ring structure and specific substituents, it endows molecules with unique activities and properties, and can interact with targets in vivo, so it plays an important role in the creation of antibacterial, anti-inflammatory and anti-tumor drugs.
In the field of materials science, 3-nitro-5-aminopyridine can participate in the preparation of functional materials. For example, by introducing it into a polymer through a specific reaction, it can change the electrical, optical or thermal properties of the material, opening up paths for the development of new optoelectronic materials and conductive polymers.
In organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. With the chemical reaction activity of amino groups and nitro groups, it can carry out various reactions such as nucleophilic substitution, reduction, coupling, etc., to help synthesize organic compounds with special structures and functions, and promote the continuous development of organic synthetic chemistry. In short, 3-nitro-5-aminopyridine is of great value in many scientific fields, providing a key material basis for related research and applications.

3-Nitro-5-aminopyridine is an important organic compound. Its synthesis methods are diverse and have their own advantages. The details are as follows:
1. ** Synthesis method using pyridine as the starting material **:
- Nitration of pyridine is carried out first. In a suitable solvent, pyridine is reacted with a mixed acid of nitric acid and sulfuric acid as a nitrifying agent to obtain 3-nitropyridine. This reaction requires careful control of temperature and reagent ratio to prevent excessive nitrification.
- Then 3-nitropyridine is aminated. A suitable amination reagent can be selected, such as ammonia and hydrogen in the presence of a catalyst, to convert the nitro group of 3-nitropyridine into an amino group, and finally obtain 3-nitro-5-aminopyridine. The choice of catalyst in this step is crucial, and metal catalysts are commonly used.
2. ** Method of synthesis through pyridine derivatives **:
- Select a suitable pyridine derivative, such as one with a substituent that can be converted into nitro and amino groups.
- Convert a specific substituent first to obtain a pyridine derivative containing nitro groups. For example, if the substituent is a halogen atom, nitro groups can be introduced by a nucleophilic substitution reaction. < Br > - Converts another substituent into an amino group, and through a series of reactions and conditions, synthesizes the target product 3-nitro-5-aminopyridine. This process requires precise control of the reaction conditions at each step to ensure the smooth progress of the reaction.
3. ** Using a new strategy for organic synthesis **:
- Coupling reaction catalyzed by transition metals. For example, using halide containing pyridine structure and reagents containing nitro and amino precursors, under the action of transition metal catalysts, the coupling of carbon-nitrogen bonds is realized to construct the target molecular structure.
- Or use emerging technologies such as photocatalysis and electrocatalysis. The conditions of this method are relatively mild and highly selective. Photocatalysis can use active intermediates generated by photoexcitation to promote the reaction, while electrocatalysis realizes specific reaction steps through electron transfer on the electrode surface to facilitate the synthesis of 3-nitro-5-aminopyridine.
The above synthesis methods have their own advantages and limitations. In practical application, it is necessary to comprehensively choose according to the availability of raw materials, the difficulty of reaction conditions, cost considerations, and the purity requirements of the target product to achieve the synthesis goal of high efficiency, economy and environmental protection.

3-Nitro-5-aminopyridine is an organic compound with specific physical properties. It is mostly solid at room temperature and has a certain melting point due to the existence of intermolecular forces. However, the exact melting point value is affected by factors such as purity, and it is commonly found in the range of 100 ° C to 150 ° C. This compound has limited solubility in water because its molecules contain hydrophobic pyridine rings. Only amino and nitro groups can form hydrogen bonds with water, resulting in poor overall water solubility. However, in organic solvents such as ethanol and dichloromethane, the solubility is relatively high, because these organic solvents and 3-nitro-5-aminopyridine molecules can form van der Waals forces and other interactions. It also has certain stability and can be stored for a certain period of time under normal conditions. However, due to its nitro content, it may have potential reactivity when heated, impacted or encountered with strong oxidants, and there is a risk of instability. In addition, the compound has a certain polarity. Because nitro and amino groups are polar groups, polarity affects its behavior in separation techniques such as chromatographic analysis, which is of great significance for its separation and detection.

3-Nitro-5-aminopyridine is an organic compound with unique chemical properties. This substance contains amino groups and nitro groups, which are complex and rich in changes in properties.
Let's talk about amino groups first, which are alkaline and can react with acids to form salts. In case of strong acid, the amino nitrogen atom will accept protons and form positively charged ammonium ions. This reaction is similar to that of many amino-containing compounds.
Besides nitro, it has strong electron absorption, which will affect the distribution of electron clouds in the pyridine ring, reduce the density of electron clouds on the ring, and increase the difficulty of electrophilic substitution reactions, especially in the adjacent and para-position. At the same time, the nitro group can undergo a reduction reaction. Under suitable conditions, it can be gradually reduced to nitroso and hydroxylamine groups, and finally an amino group can be obtained. Under the action of specific catalysts and reducing agents, the nitro group can be converted into an amino group, which changes the molecular structure and properties.
In addition, the pyridine ring itself is aromatic and follows the Shocker rule, which has special stability, which affects the overall reactivity and selectivity of the compound. 3-nitro-5-aminopyridine is widely used in the field of organic synthesis due to the interaction between amino groups and nitro groups. It can be used as a key intermediate to produce a variety of functional materials and drugs through a series of reactions. Its unique chemical properties provide many possibilities for organic synthesis and chemical research. Reaction routes need to be reasonably designed according to their properties to achieve the expected synthesis goals.

I don't know the price range of 3-nitro-5-aminopyridine in the market. The price of these chemicals often changes due to various reasons. The cost of raw materials, the difficulty of preparation, and the state of market supply and demand are all major factors that affect the price.
If the raw material cost is rare and high, the price of the finished product will also be high. The difficulty of preparation, if the preparation method is complicated, special equipment and technology are required, and the consumption of manpower and material resources is huge, the price will also increase.
In the state of market supply and demand, if there are many buyers and the supply is limited, the price will rise; if the supply is abundant and the demand is few, the price will be depressed.
And different suppliers and different quality grades have different prices. To know the exact price range, consult chemical product suppliers in detail, or find it on the chemical product trading platform.