3-nitro-4-aminopyridine

3-Nitro-4-aminopyridine is a class of organic compounds. It has a wide range of uses and has important applications in many fields.
First, in the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of various drugs. Due to its special chemical structure, it can participate in many reactions and help build molecular structures with specific biological activities. After ingenious chemical modification and synthesis steps, it can create therapeutic drugs for specific diseases, such as antibacterial, antiviral, and anti-tumor drugs, which can be developed as starting materials.
Second, in the field of materials science, 3-nitro-4-aminopyridine also has extraordinary performance. It can be used to prepare organic materials with unique functions. Due to its nitrogen, nitro and other functional groups, it can endow materials with special electrical, optical or thermal properties. Or materials with specific photoelectric conversion properties can be prepared, which may have potential applications in optoelectronic devices, such as Light Emitting Diodes, solar cells, etc., to optimize the performance of devices.
Third, as an important chemical reagent in scientific research and exploration, 3-nitro-4-aminopyridine provides assistance for the research of organic synthetic chemistry. Chemists can explore new synthesis paths and methods by performing various chemical reactions on them, expand the knowledge boundaries of organic chemistry, and open up paths for the synthesis of more novel compounds, thus promoting the sustainable development and progress of chemistry.

3-Nitro-4-aminopyridine is an organic compound whose physical properties are crucial. This compound is usually in a solid state at room temperature. Looking at its color, it can be light yellow to light brown powder. It has a specific crystal structure, which has a great influence on its many properties.
When it comes to the melting point, it is about 140-145 ° C. At this temperature, the solid state will melt into a liquid state. This melting point characteristic is an important reference for the separation, purification and identification of compounds.
Its solubility also has characteristics. In polar organic solvents, such as methanol, ethanol, and dimethyl sulfoxide, it exhibits good solubility and can be mutually soluble with these solvents in a certain proportion. However, in non-polar solvents, such as n-hexane and toluene, the solubility is poor and it is difficult to dissolve. This difference in solubility is crucial in the extraction, separation, and solvent selection of compounds.
In addition, the density of 3-nitro-4-aminopyridine is about 1.45g/cm ³. This property of density is indispensable in the conversion of substance mass and volume, as well as the study of mixed systems. Its smell is weak, but caution is still required when operating, because it may have certain toxicity and irritation.
In conclusion, the physical properties of 3-nitro-4-aminopyridine, such as its morphology, melting point, solubility, density, and odor, have far-reaching implications for its applications in chemical synthesis, materials science, and many other fields, and need to be carefully considered in research and practice.

The method of preparing 3-nitro-4-aminopyridine often follows several routes. First, 4-aminopyridine can be started. Shilling 4-aminopyridine and appropriate nitrifying reagents, such as concentrated nitric acid and concentrated sulfuric acid mixed acid, act at a suitable temperature and reaction time. At this time, it is necessary to pay attention to the control of the reaction conditions. If the temperature is too high, it is easy to cause a cluster of side reactions, such as excessive nitrification or oxidation of pyridine rings. Generally speaking, the reaction system is cooled to a lower temperature, such as 0 ° C to 5 ° C, slowly adding nitrifying reagents dropwise, and then gradually warming to room temperature or slightly higher temperature, so that the reaction can proceed smoothly. After the reaction is completed, the target product can be obtained by various separation and purification methods such as neutralization, extraction, column chromatography, etc.
Furthermore, it can start from pyridine. First, the pyridine is nitrified, and the nitro group is introduced into the pyridine ring to obtain the nitro-containing pyridine derivative. Subsequently, the nitro group is reduced to convert the nitro group into an amino group, and the reaction conditions need to be precisely adjusted to ensure that the amino group is in the required 4 positions. In this process, suitable reducing agents can be selected for the reduction step, such as iron and hydrochloric acid, hydrogen and catalyst (such as palladium carbon). When iron and hydrochloric acid are selected for reduction, the reaction conditions are relatively mild, but the post-treatment is slightly complicated; hydrogen and palladium carbon catalysis also have the advantages of high efficiency and environmental protection, but the equipment and operation requirements are higher.
Another synthesis path can be achieved by the substitution reaction of pyridine derivatives. Pyridine derivatives with suitable substituents are used as raw materials, and nitro and amino groups are gradually introduced through nucleophilic substitution or electrophilic substitution. This approach requires careful design of reaction steps and conditions according to the activity and reaction characteristics of the selected raw materials to achieve the purpose of selective synthesis of 3-nitro-4-aminopyridine.
All synthesis methods have advantages and disadvantages. In practical application, when considering the availability of raw materials, cost, purity and yield of target products, the appropriate synthesis strategy is carefully selected.

For 3-nitro-4-aminopyridine, there are several ends to be paid attention to during storage and transportation.
First, because of its certain chemical activity, it should be stored in a cool, dry and well-ventilated place. Avoid hot topics and open flames to prevent them from decomposing or triggering combustion. If heated, or cause harmful gases to escape, endangering the surrounding environment and personal safety.
Second, when stored, it needs to be stored separately from oxidants, acids, etc. Cover 3-nitro-4-aminopyridine and other substances are prone to chemical reactions, or cause violent reactions, resulting in dangerous accidents. And the storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be properly handled in a timely manner.
During transportation, the relevant regulations should also be strictly observed. The packaging must be strong and tight to ensure that there is no risk of leakage during transportation. The means of transportation should be clean and dry, and no substances that can react with it should be left. The escort personnel must also be familiar with its characteristics and emergency disposal methods, and regularly inspect during transportation. If there is any abnormality such as package damage, they should be disposed of immediately according to regulations.
Furthermore, this substance may be toxic and irritating, and contacts must take protective measures. Warning signs should be clearly displayed at the storage and transportation places to inform everyone of its potential dangers to prevent inadvertent contact and damage to the body. In this way, the safety of storage and transportation can be guaranteed.

The market price range of 3-nitro-4-aminopyridine is difficult to determine. Its price is influenced by many factors, as if it is changing and elusive.
First, the cost of raw materials is crucial. The price of raw materials required for the synthesis of this compound fluctuates from time to time. If raw materials are scarce, or the supply is limited due to natural and man-made disasters or policy changes, the price will rise, which will increase the cost of 3-nitro-4-aminopyridine, and the price will also rise.
Second, the difficulty of the production process is closely related to the cost. If the process is complicated, exquisite equipment and superb skills are required, and human and material resources are invested heavily, the product price will be higher. On the contrary, simple craftsmanship may reduce costs and make prices accessible to the people.
Third, the market supply and demand situation is like an invisible hand, which affects the price. When demand is strong and supply is insufficient, merchants can have rare goods and prices will rise; if supply exceeds demand, merchants will de-stock or reduce prices.
Fourth, the prices set by different merchants are also different. Well-known large factories have higher prices than small factories due to their brand reputation and excellent product quality. And factors such as sales area and quantity will also make prices different.
According to past market conditions, its prices may fluctuate between a few yuan per gram and tens of yuan. However, this is only a rough estimate, and the actual price needs to be consulted with the relevant chemical product suppliers in detail, depending on the current market conditions.