3-Nitro-2-pyridinecarbonitrile

3-Nitro-2-pyridylmethonitrile is widely used in the field of chemical medicine. It is a key intermediate in the synthesis of medicine. It can be chemically modified and converted into a variety of biologically active compounds for the creation of new drugs. Due to the special activity of nitro and cyano groups in its structure, it can react with other reagents in a variety of chemical reactions to build a complex molecular structure. This structure may have various pharmacological activities such as antibacterial, anti-inflammatory, and anti-tumor.
It is also indispensable in the creation of pesticides. With its chemical properties, high-efficiency and low-toxicity pesticide varieties can be derived. After a specific reaction, it is connected with various organic molecules to generate pesticide components that are highly lethal to pests and have little harm to the environment. It can precisely act on the physiological links of pests, or interfere with their nervous system, or destroy their respiratory metabolism, achieving the effect of controlling pests and protecting the growth of crops.
In the field of materials science, it has also made a name for itself. It can participate in the preparation of materials with special properties through specific processes. Or it can be used in optoelectronic materials and other fields because it can endow materials with specific electronic structure and chemical stability. By polymerizing with other monomers, new polymer materials can be obtained, or with unique electrical and optical properties, which contribute to the development of materials science. Therefore, 3-nitro-2-pyridinecarbonitrile, with its unique chemical structure, plays an important role in many fields such as medicine, pesticides, and materials science, promoting technological progress and innovation in various fields.

The synthesis of 3-nitro-2-pyridyl-methylnitrile has been described by many families in the past. One method can also be started from 2-cyanopyridine. Place 2-cyanopyridine in an appropriate reaction vessel and add an appropriate amount of nitrifying reagent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid. The mixed acid needs to be carefully prepared, and the concentrated sulfuric acid should be slowly injected into the concentrated nitric acid, and stirred at the same time to make it well mixed. After the mixed acid is cooled, 2-cyanopyridine is added dropwise at low temperature and stirred. During the reaction process, the temperature needs to be closely monitored, generally maintained in a low temperature range to prevent side reactions from occurring. After the reaction is completed, the reaction solution is poured into ice water to precipitate the product. After filtration, washing, drying and other steps, the crude product can be obtained, and then purified by recrystallization and other methods to obtain 3-nitro-2-pyridyl formonitrile.
There is another method to react 2-halo-3-nitropyridine with a cyanide reagent. Take 2-halo-3-nitropyridine first, wherein the halogen atom can be chlorine, bromine, etc. Mix it with a cyanide reagent, such as potassium cyanide or sodium cyanide, in a suitable solvent. This solvent can be selected from polar aprotic solvents such as dimethyl sulfoxide, N, N-dimethylformamide to promote the reaction. During the reaction, it needs to be heated and stirred to make the reaction sufficient. After the reaction, the solvent and unreacted raw materials are removed by conventional separation means, such as extraction, distillation, etc., to obtain the product, which needs to be further purified to achieve higher purity.
Furthermore, it can be obtained from pyridine derivatives through multi-step reaction. First, a specific substitution reaction is carried out on pyridine, and the required substituent is introduced. After a series of reactions such as oxidation, nitrification, and cyanidation, the structure of the target molecule is gradually constructed. However, this method is complicated and demanding on the reaction conditions, and the yield of each step has a great influence on the yield of the final product. It is necessary to carefully control the reaction conditions of each step in order to effectively synthesize 3-nitro-2-pyridineformonitrile.

3-Nitro-2-pyridineformonitrile is one of the organic compounds. Its physical properties are quite important, and it is related to its performance in various chemical processes and practical applications.
In terms of appearance, this compound is usually in a solid state, and its color may vary from light yellow to light brown. The characteristics of this color can help to distinguish this compound. Looking at its texture, it is mostly fine powder, which is conducive to its uniform dispersion in the reaction system and then participation in various chemical reactions.
Its melting point is also a key physical property. The melting point of 3-nitro-2-pyridinecarbonitrile is within a certain range, which is of great significance for its purification, crystallization and stability in high temperature environments. Knowing the melting point allows chemists to choose suitable separation and purification methods to ensure the purity of the product.
Furthermore, solubility cannot be ignored. In common organic solvents such as ethanol and dichloromethane, 3-nitro-2-pyridinecarbonitrile exhibits a certain solubility. This property allows it to participate in reactions in different solvent systems, providing a variety of options for the design of organic synthesis routes. In water, its solubility is poor. This property is related to the polarity of water molecules and the structure of the compound itself, and also affects its application in aqueous systems.
In addition, density is also one of its physical properties. Although its density data may not be well known to everyone, the exact value of density is also indispensable in specific application scenarios, such as when it involves the conversion of mass and volume of substances and the study of physical properties of mixed systems.
In summary, the physical properties of 3-nitro-2-pyriformonitrile, such as appearance, melting point, solubility and density, are interrelated and jointly determine its application direction and value in the chemical field and related industries. With their in-depth understanding of these properties, chemists and engineers are able to use this material more effectively, advancing the development of organic synthesis, materials science, and many other fields.

3-Nitro-2-pyridyl nitrile is an important compound in organic chemistry. Its chemical properties are unique and quite eye-catching.
This compound has nitrile (-CN) and nitro (-NO 2O) groups, which give it a variety of reactivity. Nitrile groups can be hydrolyzed and can be converted to carboxyl groups (-COOH) under acid or base catalysis to form pyridyl carboxylic acid derivatives. This reaction is often used in organic synthesis to construct carboxyl-containing compounds. At the same time, nitrile groups can also be converted into amine groups (-NH ²) through reduction reactions, thereby obtaining amino-containing pyridine derivatives, providing a path for the preparation of nitrogen-containing organic compounds. < Br >
Nitro groups are active and strong electron-absorbing groups, which reduce the electron cloud density of the pyridine ring and increase the difficulty of electrophilic substitution reaction on the ring. However, nitro groups can be reduced under specific conditions, such as under the action of metals and acids, they can be gradually reduced to nitroso (-NO), hydroxylamine (-NHOH), and finally to amine groups. This reduction process is widely used in the preparation of aminopyridine-containing compounds.
Furthermore, the pyridine ring of 3-nitro-2-pyridinecarbonitrile has aromatic properties and can undergo aromatic electrophilic substitution reactions such as halogenation, alkylation, and acylation. However, due to the influence of nitro and nitrile groups, the reaction check point and conditions are different from ordinary pyridine. In its halogenation reaction, due to the localization effect of nitro and nitrile groups, halogen atoms are often introduced into specific positions to lay the foundation for the synthesis of pyridine derivatives with specific substituents.
In summary, 3-nitro-2-pyridinecarbonitrile has rich chemical properties due to its functional groups, and has a wide range of uses in the field of organic synthesis. It can prepare a variety of valuable organic compounds.

The price of 3-nitro-2-pyridineformonitrile in the market varies depending on factors such as supply and demand, quality, and source, and it is difficult to know for sure. Looking at past transactions, the price fluctuates every time. If the quality is good and it is provided for what is urgently needed, the price may be high; if the market is abundant and there are few applicants, the price may be flat.
I have heard that in the past, the price of this thing may be as high as a thousand gold at a specific time and place; however, due to the accumulation of supply, the price may fall in the hundreds. Its price range is roughly between hundreds and thousands of gold, which is difficult to describe accurately.
If you want to know the exact price, you should consult a chemical material supplier, a trade broker, or a platform for chemical trading, and carefully observe the current market conditions in order to obtain the current price. Do not rely on old news as a basis, but should follow the changes in the market and inquire in real time to know the true meaning of the price.