3-Nitro-2-Methylpyridine 3-Nitro-2-Picoline

3-Nitro-2-methylpyridine (3-Nitro-2-Methylpyridine) and 3-Nitro-2-Picoline (3-Nitro-2-Picoline, commonly known as methylpyridine) are the same substance. Its chemical properties are unique, let me explain in detail for you.
This compound has a pyridine ring structure, and there are two types of substituents, nitro and methyl. The pyridine ring is active in nature. Due to the existence of nitrogen atoms, it is weakly basic and can react with acids to form salts. The lone pair electrons on the nitrogen atom can participate in the coordination and complex with metal ions.
The nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the pyridine ring, makes the electrophilic substitution reaction more difficult to occur, but makes the nucleophilic substitution reaction easier to proceed. And the nitro group can be reduced and converted into an amino group through a series of reactions. This is an important step in organic synthesis. For example, iron and hydrochloric acid are used as reducing agents, and the nitro group can be changed to an amino group to obtain 3-amino-2-methyl pyridine, which is of great significance in the preparation of fine chemicals such as drugs and dyes.
The methyl group is the donon group, which increases the electron cloud density of the pyridine ring to a certain extent, which has a subtle effect on the reactivity. In some reactions, methyl groups can be oxidized, such as under the action of suitable oxidants, they can be converted into carboxyl groups to obtain 3-nitro-2-pyridinecarboxylic acid.
3-nitro-2-methylpyridine has both these chemical properties and is widely used in the field of organic synthesis. It can be used as a key intermediate for the creation of many high-value chemicals.

3-Nitro-2-methylpyridine (3-Nitro-2-Methylpyridine) and 3-Nitro-2-Picoline (3-Nitro-2-Picoline, this name is different from the former for the same substance) Common synthesis methods are as follows:
First, 2-methylpyridine is used as the starting material. In an appropriate reaction vessel, 2-methylpyridine is added, and a mixed acid composed of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying agent. It is crucial to control the reaction temperature, which is generally maintained at a low temperature range, such as 0-10 ° C, and the mixed acid is slowly added dropwise to prevent the reaction from being too violent. During this reaction, nitrification occurs at a specific position on the pyridine ring of 2-methylpyridine, resulting in 3-nitro-2-methylpyridine. After the reaction is completed, the reaction solution is poured into ice water, and the product can be obtained through post-treatment steps such as extraction, washing, drying and distillation. Due to the strong oxidizing and nitrifying ability of mixed acids, hydrogen atoms on the pyridine ring can be replaced by nitro groups, and specific reaction conditions can promote the main substitution of nitro groups at the 3 position.
Second, use 2-halo-3-nitropyridine as raw material. Take 2-halo-3-nitropyridine and place it in the reaction system, add appropriate metal reagents, such as magnesium chips, to form Grignard's reagent. Then add methylating reagents such as iodomethane to the system. After a series of reactions, the halogen atoms are replaced by methyl groups to form 3-nitro-2-methylpyridine. This method takes advantage of the activity of Grignard's reagents to achieve methylation at specific locations. After the reaction is completed, the target product is obtained by conventional separation and purification methods, such as column chromatography.
Or, 3-nitropyridine is used as the raw material. The methylation reaction of 3-nitropyridine is carried out first, and a suitable methylation reagent is selected, such as dimethyl sulfate. Under basic conditions, such as the presence of potassium carbonate, the nitrogen atom of 3-nitropyridine first undergoes quaternization, and then through the process of intramolecular rearrangement and deprotonation, methyl groups are introduced into the second position of the pyridine ring to generate 3-nitro-2-methylpyridine. After the reaction is completed, the pure product is separated by neutralization, extraction, distillation and other operations. This approach skillfully realizes the introduction of methyl-based pyridine rings at specific locations through methylation reagents and basic environments.

3-Nitro-2-methylpyridine (3-Nitro-2-Methylpyridine) and 3-Nitro-2-Picoline (3-Nitro-2-Picoline, in fact, are the same substance as the former, picoline is the old name of methyl pyridine), both of which have wonderful uses in many fields.
In the field of medicinal chemistry, it is often the key raw material for the synthesis of specific drugs. The unique structure of the pyridine ring gives compounds a variety of biological activities. Based on it, it can be modified by exquisite chemistry to create antibacterial, anti-inflammatory and anti-tumor drugs, which make outstanding contributions to healing diseases and benefiting living beings.
In the field of materials science, it can be used as an important component in the synthesis of special functional materials. By introducing it into the structure of polymer materials through specific chemical reactions, the electrical, optical and thermal properties of materials can be significantly improved. For example, the preparation of organic semiconductor materials with unique photoelectric response shows broad application prospects in electronic devices, such as organic Light Emitting Diodes (OLEDs) and solar cells.
In the field of agricultural chemistry, it also has extraordinary value. With this as a starting material, high-efficiency and low-toxicity pesticides can be developed, or they have the functions of insecticides, sterilization, and weeding. It has made great contributions to ensuring the healthy growth of crops and increasing yields. Due to its structural characteristics, it may endow pesticides with good environmental compatibility, which is in line with the current trend of green agriculture development.
Furthermore, in organic synthesis chemistry, it is an extremely important intermediate. With the active reactivity of nitro and methyl groups on the pyridine ring, complex organic molecular structures can be constructed through various classical organic reactions, such as nucleophilic substitution, reduction, coupling, etc., to help organic synthesis chemists explore novel compounds and expand the boundaries of organic chemistry.

3 - Nitro - 2 - Methylpyridine and 3 - Nitro - 2 - Picoline are actually the same substance. 3 - Nitro - 2 - Picoline is the common name for 3 - Nitro - 2 - Methylpyridine. Its market price is not static and will be influenced by many factors.
From the perspective of raw materials, if the price of pyridine and its derivatives, nitrifying reagents and other raw materials required for the preparation of 3-Nitro-2-Methylpyridine rises, or due to the shortage of raw materials, such as natural disasters in some raw material origins, political situations resulting in poor supply channels, etc., will increase production costs, thereby driving up the price of 3-Nitro-2-Methylpyridine.
The production process is also a key factor. Advanced and efficient production processes can reduce energy consumption, improve product purity and yield, and effectively control costs. If a production enterprise develops an optimized process that greatly reduces production costs, it may sell at a better price in the market competition. On the contrary, if the process is backward, the cost will remain high and the price will be high.
The relationship between supply and demand in the market has a great impact. In the fields of medicine, pesticides, materials, etc., if the demand for 3-Nitro-2-Methylpyridine is strong, if the demand for new drug research and development increases greatly, and the production capacity of the production enterprise is temporarily difficult to meet, the price will rise. If the market demand is weak and the inventory of the enterprise is overstocked, the enterprise may reduce the price and promote in order to remove the inventory.
The market competition situation cannot be ignored either. When there are many companies producing 3-Nitro-2-Methylpyridine in the market and the competition is fierce, the enterprises may reduce the price in order to ensure the quality. If the market is monopolized by a few companies, they may manipulate the price by virtue of their monopoly position.
Generally speaking, the current price of 3-Nitro-2-Methylpyridine may range from tens to hundreds of yuan per kilogram. However, this is only a rough range. The exact price needs to be consulted with the relevant chemical product suppliers and distributors, or refer to the real-time quotation of the chemical product trading platform to obtain accurate market price information.

3-Nitro-2-methylpyridine (3-Nitro-2-Methylpyridine) and 3-Nitro-2-Picoline (3-Nitro-2-Picoline, another name for 3-nitro-2-methylpyridine), both are active in nature and should be stored with caution.
First of all, it should be placed in a cool and dry place. Because it is quite sensitive to temperature and humidity, high temperature and humid places are prone to deterioration, causing chemical reactions and damaging its purity and quality.
Furthermore, it should be avoided in broad daylight. When exposed to light, these substances are prone to photochemical reactions, resulting in structural changes and damaged performance. Therefore, it needs to be stored in an opaque container or placed in a dark place.
In addition, the air must be circulated where it is stored. If the air is not smooth, once the substance leaks, harmful gases are easy to accumulate, which not only endangers the surrounding environment, but also poses a threat to personal safety.
Because of its certain toxicity and corrosiveness, it must be stored away from fire and heat sources, and must not be mixed with flammable, explosive, strong oxidizing agents and reducing agents to prevent unexpected chemical reactions, causing fires, explosions and other disasters.
Storage containers must also be firmly sealed. Glass containers, although the internal condition can be seen, must be prevented from being damaged; metal containers should be paid attention to whether they will react with substances. After taking it, be sure to seal it in time to prevent the substance from changing due to excessive contact with the air.
In short, 3-nitro-2-methylpyridine and 3-nitro-2-picoline should be stored in a cool, dry, dark and ventilated place, away from all kinds of dangerous items, and properly stored in a sturdy and sealed container, so as to keep their properties stable and ensure safe storage.