3-methylpyridine-2-carboxylic acid

3-Methylpyridine-2-carboxylic acid, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. As far as the preparation of specific drugs is concerned, its pyridine ring and carboxyl group can be modified through a series of chemical reactions, and then a molecular structure with specific biological activities can be constructed. Due to the chemical properties of the pyridine ring and the carboxyl group, it can participate in many bonding reactions, such as condensation reactions with other compounds containing active groups, to form drug molecules with different pharmacological activities, which can be used to develop drugs for the treatment of various diseases. For example, in the synthesis of some anti-infection and anti-tumor drugs, 3-methylpyridine-2-carboxylic acid may be used as the starting material.
In the field of materials science, it also has applications. It can take advantage of its unique molecular structure to coordinate with metal ions to prepare metal-organic framework materials (MOFs). Due to their high specific surface area, regular pore structure and other characteristics, these materials exhibit excellent performance in gas adsorption and separation, catalysis, etc. For example, in the field of gas adsorption, the prepared MOFs materials can exhibit highly selective adsorption of specific gases, which helps to achieve efficient separation of mixed gases.
In the field of agricultural chemistry, 3-methylpyridine-2-carboxylic acid can be used to synthesize pesticides. After chemical modification, it can be made to have insecticidal, bactericidal or herbicidal effects, providing protection for the growth of crops. Because its structure contains nitrogen and carboxyl groups, it can interact with specific targets in organisms and interfere with the physiological processes of pests or pathogens, thus achieving the purpose of control.
In summary, 3-methylpyridine-2-carboxylic acids play an indispensable role in the fields of medicine, materials, and agricultural chemistry due to their unique chemical structure, which is of great significance for promoting the development of related fields.

3-Methylpyridine-2-carboxylic acid, its physical properties are as follows:
This substance is mostly solid under normal conditions, and it may appear as a white to off-white crystalline powder. Its melting point is quite critical, about 135-138 ° C. This temperature characteristic is very important in the identification and purification of this substance. With this temperature as the boundary, the state of the substance gradually changes from solid to liquid, which is relied on by many experimental operations and industrial production processes.
In terms of solubility, it has a certain solubility in water, but the solubility is not very high. In organic solvents, such as ethanol, acetone and other common organic solvents, the solubility is relatively good. This property allows the appropriate solvent to be selected according to its dissolution characteristics during extraction, separation and chemical reaction operations to achieve the desired experimental purpose. For example, in some organic synthesis reactions, using ethanol as a solvent can better disperse 3-methylpyridine-2-carboxylic acid in the reaction system and promote the reaction to proceed fully.
Its density is also an important physical parameter, although the exact value varies slightly due to measurement conditions, roughly speaking, it is in the range of 1.2-1.3 g/cm ³. The value of density is not only related to the characteristics of the substance itself, but also has an impact on container selection and space planning in practical applications, such as material storage and transportation.
In addition, the smell of 3-methylpyridine-2-carboxylic acid is weak, and it usually needs to be detected by close sniffing, and the smell is not strongly irritating. This point is also significant in the working environment and human experience during use. Its physical properties, such as appearance, melting point, solubility, density, and odor, are interrelated and have their own uses. They are all indispensable factors to consider in chemical research, chemical production, and related fields.

3-Methylpyridine-2-carboxylic acid is one of the organic compounds. It has many unique chemical properties and plays a significant role in the field of organic synthesis.
This compound contains a pyridine ring and a carboxyl group. The pyridine ring has an aromatic ring structure, which endows it with certain stability and aromaticity. Due to the presence of nitrogen atoms, the electron cloud of the pyridine ring is unevenly distributed, which makes the 3-methylpyridine-2-carboxylic acid exhibit a unique electronic effect. The lone pair electron of the nitrogen atom can participate in the reaction, making the pyridine ring more prone to nucleophilic substitution.
The carboxyl group is a strong polar group, which endows 3-methylpyridine-2-carboxylic acid. In aqueous solution, the carboxyl group can partially ionize hydrogen ions, presenting acidic characteristics. With this acidity, it can neutralize with bases to form corresponding carboxylic salts.
The methyl group of 3-methylpyridine-2-carboxylic acid is attached to the pyridine ring, and the methyl group is the donator group, which affects the electron cloud density of the pyridine ring, thereby changing its reactivity and selectivity. For example, in electrophilic substitution reactions, the donator action of methyl groups can make the reaction more likely to occur at specific locations in the pyridine ring.
In terms of chemical reactivity, the carboxyl group of 3-methylpyridine-2-carboxylic acid can participate in many typical reactions. For example, esterification reactions occur with alcohols catalyzed by acids to generate corresponding ester compounds. In addition, carboxyl groups can also be converted into derivatives such as acid chlorides and acid anhydrides, which are important intermediates in organic synthesis and can further participate in various reactions, such as reacting with amines to form amides.
Due to its unique structure and chemical properties, 3-methylpyridine-2-carboxylic acids are widely used in many fields such as medicine, pesticides, and materials. In the field of medicine, or as a key intermediate for the synthesis of specific drugs; in the field of pesticides, or can be used to create new pesticide active ingredients; in the field of materials, or can participate in the preparation of functional materials.

The synthesis method of 3-methylpyridine-2-carboxylic acid has been investigated by many parties throughout the ages, and is briefly described as follows.
First, 3-methylpyridine is used as the starting material. First, 3-methylpyridine is oxidized, and suitable oxidants can be selected, such as potassium permanganate, potassium dichromate and other strong oxidants. Under appropriate reaction conditions, such as specific temperature and solvent environment, the methyl groups on the pyridine ring are oxidized to carboxyl groups to obtain 3-methylpyridine-2-carboxylic acid. The principle of this method is clear, but the reaction conditions need to be precisely controlled, otherwise it is easy to cause damage to the pyridine ring and affect the yield and purity of the product. < Br >
Second, with the help of metal catalysis coupling reaction. With suitable halogenated pyridine derivatives and methyl- and carboxyl-containing synthesizers, under the action of metal catalysts such as palladium, the target molecule is constructed by coupling reaction. In this path, the selection of halogenated pyridine derivatives, the design and preparation of methyl- and carboxyl-containing synthesizers are all key. And the activity of metal catalysts and the choice of reaction ligands also have a great influence on the reaction process and results. The desired product can be obtained by carefully adjusting the reaction parameters.
Third, biosynthesis is also a way. Using the catalytic action of specific microorganisms or enzymes, 3-methylpyridine-2-carboxylic acid is synthesized with suitable substrates through biological metabolism. This method is green and environmentally friendly, and the conditions are mild. However, high-efficiency microorganisms or enzymes need to be screened. The biological system is relatively complex, and the reaction environment requirements are strict. The control of culture conditions also requires fine operation to ensure the smooth progress of biocatalysis.
All these synthetic methods have their own advantages and disadvantages. It is necessary to weigh the choices according to actual needs and conditions in order to achieve the purpose of efficient synthesis of 3-methylpyridine-2-carboxylic acid.

The price of 3-methylpyridine-2-carboxylic acid in the market is difficult to determine. Its price often changes due to many reasons, such as the price of raw materials, the simplicity of the process, the situation of demand and supply, the competition of the market, etc.
Looking at the market conditions in the past, if it is an ordinary grade, the price of quantity purchase is several hundred yuan per kilogram or more. However, the price of raw materials rises, or the process is special, the price also rises.
And the prices quoted by different merchants also vary. Large merchants have a large amount of production due to the superiority of the regulations, and their prices may be more affordable; while small merchants have a small amount and a high cost, and their prices may be slightly higher. < Br >
The situation of demand and supply has a heavy impact on the price. If you want prosperity but less supply, the price will rise; if the supply exceeds the demand, the price will be depressed.
As for high-purity products, due to the difficulty of making them, they need to be refined and strictly controlled. The price must be higher than that of ordinary products, or thousands of yuan per kilogram.
To know the exact price, it is advisable to consult chemical raw material suppliers, chemical trading markets, or explore chemical e-commerce platforms to get a timely and accurate price.