3-methyl-pyridine-2-carbaldehy

3-Methyl-pyridine-2-formaldehyde, this substance has unique properties and various physical properties. It is an important substance for chemical investigation.
It is a colorless to light yellow liquid with a clear appearance. Under normal light and temperature, it can be seen that it is slightly flooded, which seems to be a natural beauty. Its taste is unique, and it has a pungent odor. Although this smell is not rich, it is unique, and its unique smell can be felt from a distance.
When it comes to the melting point, the melting point is very low, about -20 ° C, and it will not solidify in case of mild cold. The boiling point is moderate, between 210 and 212 ° C. In this temperature range, the conversion between liquid and gaseous states can be realized. This boiling point characteristic has a great impact on the separation and purification operations in many chemical processes.
Its solubility is also considerable. It can be miscible with common organic solvents, such as ethanol and ether, in any ratio, just like water emulsion, indistinguishable from each other. However, the solubility in water is limited, and it can only be dissolved a little, which seems to be opposed to water. This difference in solubility lays the foundation for its application in different systems.
In terms of density, it is about 1.10-1.12 g/cm ³, which is slightly heavier than water. It is placed in water, such as a stone sinking abyss, and slowly settles.
In addition, 3-methyl-pyridine-2-formaldehyde still has a certain volatility. In the exposed environment, its amount gradually decreases over time, as if it is quietly invisible. This volatility also poses special requirements for its preservation and use environment.
All physical properties are intertwined to form a unique physical "picture" of 3-methyl-pyridine-2-formaldehyde, providing rich possibilities for applications in chemical, pharmaceutical and other fields.

3-Methyl-pyridine-2-formaldehyde, this is an organic compound. It has many unique chemical properties.
Let's talk about the physical properties first. At room temperature and pressure, it is often liquid and has a special smell. Due to the polar groups in the structure, it has a certain solubility in specific organic solvents. For example, it can be soluble in organic solvents such as ethanol and ether, but it is difficult to dissolve in water. This is caused by the difference between the polarity of the molecule and the polarity of the water molecule.
Looking at the chemical properties, its aldehyde group is active. Oxidation reaction can occur. In case of strong oxidants, such as acidic potassium permanganate solution, aldehyde groups can be oxidized to carboxyl groups, thereby converting into 3-methyl-pyridine-2-carboxylic acids; in case of weak oxidants, such as Torun reagent, silver mirror reaction can occur, aldehyde groups are oxidized to carboxyl groups, and metal silver is generated at the same time, forming a bright silver mirror on the wall of the test tube. This reaction can be used to identify aldehyde groups.
It can also undergo reduction reaction. Under the action of suitable reducing agents such as sodium borohydride, aldehyde groups can be reduced to hydroxyl groups to generate 3-methyl-2-hydroxymethylpyridine.
In addition, aldehyde groups can undergo addition reactions with compounds containing active hydrogen. For example, under acid catalysis with alcohols, hemiacetal is first added to generate acetal, which is often used to protect aldehyde groups in organic synthesis.
The pyridine ring also gives the compound special properties. The pyridine ring has a certain alkalinity, because there are solitary pairs of electrons on the nitrogen atom, it can accept protons. Therefore, 3-methyl-pyridine-2-formaldehyde can react with acids to form salts, enhancing its solubility in water. Pyridine rings can also undergo electrophilic substitution reactions, but due to the electron-withdrawing action of nitrogen atoms, the reaction activity is lower than that of benzene rings, and the substituents mainly enter the 3 and 5 positions of the pyridine ring.

3-Methyl-pyridine-2-formaldehyde has a wide range of uses. In the chemical industry, it is often used as an intermediary in organic synthesis. Because its molecular structure contains specific functional groups, it can be used for many chemical reactions to produce a variety of organic compounds.
In the field of pharmaceutical chemistry, it is a key raw material for the synthesis of a variety of drugs. With it as a starting material, through delicate reaction steps, molecular structures with specific pharmacological activities can be constructed, or used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs. Medicinal chemists design and synthesize new compounds according to their characteristics, and pharmacologically test them to explore potential therapeutic drugs.
In the field of materials science, it also has important uses. Or can participate in the synthesis of functional materials, such as luminescent materials, conductive materials, etc. Through the chemical reactions it participates in, the materials are endowed with specific optical, electrical and other properties, providing opportunities for material improvement and innovation.
In the fragrance industry, 3-methyl-pyridine-2-formaldehyde can be used as a raw material for fragrance synthesis. Due to its unique chemical structure, through appropriate reaction and transformation, compounds with special aromas can be obtained, which can be used to prepare various flavors and increase the aroma quality of products.
In short, 3-methyl-pyridine-2-formaldehyde plays an important role in chemical, pharmaceutical, materials, fragrances and other fields, and has made great contributions to the development of related industries.

The synthesis method of 3-methyl-pyridine-2-formaldehyde, although the classic "Tiangong Kaiji" does not contain the specific synthesis method of this compound, it can be deduced according to the usual method of chemical synthesis and the principle of organic synthesis.
First, using 3-methyl pyridine as the starting material, the aldehyde group can be introduced by mild oxidation method. For example, under specific catalyst and suitable reaction conditions, 3-methyl pyridine is treated with a mild oxidizing agent such as chromium trioxide-pyridine complex (Collins reagent) to oxidize the methyl group at the 2-position of the pyridine ring to an aldehyde group. This reaction condition is relatively mild and can reduce side reactions such as pyridine epoxidation. The reaction is roughly as follows: 3-methylpyridine and Collins reagent are stirred in an organic solvent such as dichloromethane under low temperature and inert gas protection, and the product can be obtained after post-treatment such as extraction, washing, distillation and other steps.
Second, the strategy of halogenation reaction with metal-organic reagents can be used. First, 3-methylpyridine is halogenated under suitable conditions, and a halogen atom is introduced at the 2-position of the pyridine ring. For example, N-bromosuccinimide (NBS) is used as the bromination reagent, and the bromination reaction is carried out in the presence of an initiator. 3-Methyl-pyridine-2-formaldehyde can be obtained by the reaction of 2-halo-3-methylpyridine with metal-organic reagents such as Grignard reagent (R-MgX) or organolithium reagent (R-Li), and then hydrolysis and oxidation steps. For example, 2-bromo-3-methylpyridine is prepared first, and the corresponding tertiary alcohol intermediate is obtained by reacting with methyl Grignard reagent, and then oxidized to aldehyde by Dess-Martin periodine and other oxidants.
Third, the coupling reaction strategy catalyzed by palladium can also be used. Using 3-methylpyridine as raw material, through the pyridine ring 2-position halogen and the borate ester or boric acid derivative containing aldehyde group, under the catalysis of palladium catalyst such as tetra (triphenylphosphine) palladium (Pd (PPh)), the Suzuki coupling reaction is carried out in basic conditions and suitable solvents, and the target product 3-methyl-pyridine-2-formaldehyde can be obtained after subsequent treatment.
All these synthesis methods have their own advantages and disadvantages, and need to be selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the high cost.

3-Methyl-pyridine-2-formaldehyde is an important organic compound. When storing and transporting, the following matters should be paid attention to:
First, the storage place must be cool and dry. This substance is afraid of moisture and moisture. If the storage environment is humid, it is easy to cause deterioration. For example, in the rainy season in the south, the air humidity is quite high, if it is not properly stored, it is easy to damage its quality. And the temperature should not be too high, because high temperature may cause chemical reactions to occur, resulting in damage to its stability.
Second, it needs to be sealed and stored. 3-Methyl-pyridine-2-formaldehyde easily reacts with oxygen and other components in the air. Sealed storage can effectively isolate the air and slow down its deterioration. If a well-sealed container is used, ensure that no air enters.
Third, the storage place should be away from fire and heat sources. This compound is flammable to a certain extent, and may cause combustion or even explosion in case of open flames and hot topics. Just like in a chemical storage warehouse, if there is a fire source nearby, once the substance leaks, the consequences will be unimaginable.
Fourth, during transportation, ensure that the packaging is complete and stable. Prevent package damage due to bumps and collisions, resulting in material leakage. If strong packaging materials are used and properly fixed.
Fifth, the means of transportation must be clean and dry, and no substances that can react with them should be left. For example, if a vehicle transporting acidic substances is not thoroughly cleaned, it will transport 3-methyl-pyridine-2-formaldehyde, which may cause chemical reactions.
Sixth, it must be stored and transported in strict accordance with the regulations on relevant hazardous chemicals. Due to its special nature, following regulations can ensure the safety of personnel and the environment is not polluted.