3-methyl 5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

This is an organic compound, named 3-methyl-5-isopropyl-2-cyano-6-methyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate. According to its naming, its chemical structure can be gradually deduced according to the rules of organic chemistry.
"1,4-dihydropyridine" indicates that the core structure of this compound is a dihydropyridine ring, which has a heterocycle of six atoms, in which the nitrogen atom occupies one place, and the two-position and three-position, five-position and six-position are double bonds, but there is no double bond between the four-position and one-position, so it is a dihydrogen structure.
"3-methyl" means adding a methyl ($- CH_3 $) to the third position of the dihydropyridine ring; "5-isopropyl" indicates that the fifth position is connected with isopropyl ($-CH (CH_3) _2 $); "2-cyano" indicates that the second position is connected with cyano ($-CN $); "6-methyl" refers to the sixth position with methyl; "4 - (3-nitrophenyl) " indicates that the fourth position is connected to a phenyl group, and the third position of this phenyl group has a nitro group ($- NO_2 $); "3,5-dicarboxylate" shows the structure of the third position and the fifth position each connected with a carboxylic acid ester.
This compound has a complex structure, and each substituent endows it with unique chemical properties and reactivity, which may be of great significance in the fields of organic synthesis and medicinal chemistry. In its structure, the dihydropyridine ring is the active center, and the surrounding substituents may affect its electron cloud distribution and steric hindrance, which in turn affect its chemical reaction and biological activity.

3-Methyl-5-isopropyl-2-cyano-6-methyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate, this is a class of organic compounds with several unique physical properties.
Looking at its morphology, under normal temperature and pressure, it is mostly in the state of a crystalline solid, with a regular crystalline structure, resulting in a delicate and regular crystalline appearance and relatively solid texture. The color of this compound is often white or off-white. When it is pure, it is as white as snow, and under the light, it is crystal clear.
When it comes to melting point, due to the existence of various functional groups in the molecular structure, they interact with each other, resulting in a high melting point. The functional groups restrict each other, so that the molecules are arranged in a tight and orderly manner. It takes a high energy to break the lattice structure and convert the solid state into a liquid state. The specific melting point may vary slightly depending on the purity and test conditions.
In terms of solubility, because its molecules have both polar and non-polar parts, they exhibit unique solubility properties in organic solvents. In polar organic solvents, such as ethanol and acetone, it can form hydrogen bonds or other intermolecular forces with solvent molecules, so it has a certain solubility; in non-polar organic solvents, such as n-hexane, the solubility is relatively poor, because the interaction between the non-polar part and the non-polar solvent is weak.
In addition, due to the specific conjugated system and functional groups of this compound, there will be characteristic absorption peaks in the ultraviolet-visible spectral region, which can be qualitatively and quantitatively detected by spectral analysis. In the infrared spectrum, each functional group also exhibits a characteristic absorption frequency, which helps to accurately identify various chemical bonds and functional groups in the molecule.
In summary, the physical properties of 3-methyl-5-isopropyl-2-cyano-6-methyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid esters are rich and diverse, which lay the foundation for their application in organic synthesis, drug development and other fields.

3-Methyl-5-isopropyl-2-cyano-6-methyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate, an organic compound. It is widely used in the field of medicine and is often used as a key intermediate of calcium channel blockers. Calcium channel blockers can regulate the flow of calcium ions inside and outside the cell, thereby dilating vascular smooth muscles, reducing peripheral vascular resistance and blood pressure. Therefore, they can be used in the treatment of hypertension. In addition, it can also affect myocardial contractility, heart rate and conduction function by regulating the influx of calcium ions in cardiomyocytes, and then be used for the prevention and treatment of arrhythmia and angina pectoris.
In the field of organic synthesis, this compound can act as an important synthetic building block due to its unique structure and reactivity. With its various functional groups, such as cyano and ester groups, it can carry out various organic reactions, such as hydrolysis, addition, substitution, etc., and then synthesize organic compounds with more complex and diverse structures, providing key intermediates for the research and development of new drugs and materials.
In the field of materials science, some derivatives synthesized based on this compound may have special optical and electrical properties, or can be used to prepare functional materials such as organic Light Emitting Diodes and photoconductors, opening up new paths for the development of materials science.

To prepare 3-methyl-5-isopropyl-2-cyano-6-methyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate, the method of organic synthesis is often followed.
First, a compound containing a pyridine ring is used as the starting material. First, take a suitable pyridine derivative, which needs to have a modifiable check point to facilitate subsequent reactions. If a pyridine with a specific substituent is selected, its substituent can be converted under specific conditions. The base is used as a medium to make the pyridine derivative meet the cyanogen-containing reagent. The base can activate the pyridine ring, so that the cyanyl group can be successfully integrated to form the cyanogen-containing pyridine intermediate. This process requires strict control of the reaction temperature and time. If the temperature is too high, side reactions will occur, and if it is too low, the reaction will be delayed.
Second, the desired substituent is introduced at other check points of the intermediate pyridine ring. The halogenated alkyl is used as the alkylation reagent, and with the help of metal catalysts and ligands, it reacts with the cyanopyridine-containing intermediate to achieve the introduction of 3-methyl and 5-isopropyl. The metal catalyst can activate the halogenated alkane and promote the formation of carbon-carbon bonds In this step, the choice of solvent is also critical. It is necessary to choose the one that has good solubility between the reactants and the catalyst and does not interfere with the reaction.
Third, to construct a dihydropyridine ring. Using the condensation reaction, the substituted pyridine intermediate reacts with the dicarbonyl compound under the catalysis of acid. The acid can promote enolization and nucleophilic addition, and cyclize to form a 1,4-dihydropyridine structure. In this process, the ratio of the reactants needs to be precisely regulated, otherwise the yield and purity of the target product will be affected.
Fourth, 3-nitrophenyl is introduced. Using a halogenated aromatic hydrocarbon containing 3-nitrophenyl as a raw material, 3-nitrophenyl is connected to the 4-position of the 1,4-dihydropyridine ring through a palladium-catalyzed coupling reaction. The palladium catalyst has high activity and can efficiently promote the formation of carbon-carbon bonds. The reaction system needs to be anhydrous and oxygen-free to prevent the catalyst from deactivating.
Fifth, form a dicarboxylic acid ester structure. The corresponding alcohol is reacted with an acyl halide or an acid anhydride to introduce a carboxylic acid ester group at the 3,5-position of the pyridine ring. This reaction is mild and easy to control, and the target product 3-methyl-5-isopropyl-2-cyano-6-methyl-4 - (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate can be obtained. However, after each step of reaction, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to remove impurities and obtain pure products.

3-Methyl-5-isopropyl-2-cyano-6-methyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate, this is a complex organic compound. During use, many matters need to be paid careful attention.
The first priority is safety protection. Because it has certain chemical activity, or it may be toxic and irritating to the human body. When operating, be sure to wear protective clothing, protective gloves and goggles to prevent skin and eye contact. If you accidentally touch it, rinse it with plenty of water immediately and seek medical attention as appropriate. Operate in a well-ventilated place to avoid inhaling its volatile gas to prevent damage to the respiratory tract.
Furthermore, pay attention to its chemical properties. This compound contains functional groups such as dihydropyridine, cyano, nitro, etc., and has unique chemical activities. In case of specific reagents or conditions, or chemical reactions. Before use, check its chemical properties and reaction characteristics carefully to avoid mixing with incompatible substances to prevent dangers such as explosion and fire.
Storage should also be paid attention to. It should be stored in a cool, dry and ventilated place, away from fire sources, heat sources and oxidants. Because it may be photosensitive or heat-sensitive, it needs to be stored away from light and temperature control to prevent deterioration.
When taking it, precisely control the dosage. Due to its high reactivity, the dosage deviation or the reaction is out of control or the product is impure. According to the experimental or production requirements, it can be used with precision measuring tools.
Post-treatment should not be ignored. After use, properly dispose of the residue and waste. According to local environmental regulations, collect and dispose of them separately to prevent environmental pollution.
Use 3-methyl-5-isopropyl-2-cyano-6-methyl-4 - (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate, and must strictly follow safety procedures and operating guidelines to ensure personnel safety and smooth experimentation and production.