3-Methoxy-6-(trifluoromethyl)pyridine-2-carbaldehyde

3-Methoxy-6- (trifluoromethyl) pyridine-2-formaldehyde is widely used in the field of organic synthesis.
First, it can be used as a key intermediate in pharmaceutical synthesis. Among many drug molecular structures, the pyridine and aldehyde structures of this compound are all active check points. After specific chemical reactions, such as condensation, oxidation of aldehyde groups, and substitution of pyridine rings, it can be ingeniously converted into compounds with more complex structures, and then new drugs can be developed. Taking antimalarial drugs as an example, by modifying and modifying the structure of this compound, new antimalarial drugs with high efficiency and low toxicity may be found.
Second, it also has important applications in the field of pesticides. Because of its unique chemical structure, or with certain biological activity. It can react with other compounds to prepare pesticides, fungicides and other pesticide products. Its fluorine and methoxy structure may give pesticides better stability, fat solubility and biological activity, and improve the control effect of pesticides on pests and diseases.
Third, it also has potential uses in materials science. With its specific electronic structure and chemical properties, it may participate in the preparation of functional materials. For example, it is used in the synthesis of organic optoelectronic materials. Due to the conjugated structure of pyridine ring and aldehyde group, it may affect the optical and electrical properties of the material, so it is used in the fields of organic Light Emitting Diodes, solar cells and so on.
Furthermore, as an important building block of organic synthetic chemistry, chemists can build multiple heterocyclic compounds through various reactions based on this compound. Through the precise regulation and transformation of its functional groups, the structural diversity of organic compounds can be expanded, providing rich materials and research bases for the development of organic synthetic chemistry.

3-Methoxy-6- (trifluoromethyl) pyridine-2-formaldehyde, this is an organic compound. Its physical properties are quite important and are related to many chemical applications.
First, the appearance is usually solid or liquid, depending on the environmental conditions. If the temperature is suitable, or it is a colorless to light yellow liquid, the texture is clear; if the temperature is low, it may condense into a white to almost white solid.
Melting point and boiling point are also key physical properties. Its melting point determines the temperature from solid to liquid, while the boiling point is related to the temperature from liquid to gas. Although the exact value needs to be determined by professional experiments, it is inferred from its molecular structure and the properties of similar compounds that the melting point may be in a relatively low temperature range, because the intermolecular force is not extremely strong; the boiling point or in a certain moderate temperature range reflects the degree of intermolecular interaction.
In terms of solubility, this compound has good solubility in organic solvents, such as common ethanol, dichloromethane, acetone, etc. There are polar groups in the Gain molecule, such as methoxy and aldehyde groups, which can interact with organic solvent molecules to improve solubility. However, its solubility in water may be limited, because it contains hydrophobic trifluoromethyl, which will reduce its affinity with water molecules.
Density is also a property that cannot be ignored. Although there is no exact data, it can be roughly speculated according to its structure. Due to the presence of fluorine atoms, the relative density or the slightly higher than that of common hydrocarbon compounds, the relative atomic weight of fluorine atoms is larger, and the structure of trifluoromethyl is compact, which increases the molecular weight and increases the density.
In addition, the volatility and stability of this compound are also of concern. Because it contains an aldehyde group, it has a certain activity. Under specific conditions, reactions such as oxidation may occur, which affects the stability. Volatility or moderate, depending on its boiling point and intermolecular forces, in an open system, or evaporates slowly.

The method of preparing 3-methoxy-6- (trifluoromethyl) pyridine-2-formaldehyde often follows several paths. First, the methoxy group and trifluoromethyl group are introduced into the pyridine ring by a nucleophilic substitution reaction from the starting material containing the pyridine ring. Select an appropriate pyridine derivative, such as halogenated pyridine, and react with a methoxylating agent, such as sodium methoxide, in a suitable solvent, such as N, N-dimethylformamide (DMF), and then use a trifluoromethylating agent, such as sodium trifluoromethanesulfonate, to introduce trifluoromethyl groups under specific reaction conditions. < Br >
Second, pyridine-2-formaldehyde is used as the starting material. The aldehyde group of the 2-position of pyridine-2-formaldehyde is first protected to prevent subsequent reactions from being disturbed. Ethylene glycol is selected to react with the aldehyde group to generate the acetal protecting group. Subsequently, methoxylation and trifluoromethylation of the pyridine ring are carried out. Methoxylation can be carried out according to the above nucleophilic substitution method, and trifluoromethylation can also be used with related reagents and conditions. After the substitution is completed, under acidic conditions, the acetal is hydrolyzed and the aldehyde group is re-released to obtain the target product.
Third, a metal-catalyzed cross-coupling reaction is used. With halogenated pyridine derivatives as substrates, combined with methoxy borate and trifluoromethylborate, cross-coupling reactions occur in appropriate bases and solvents under the action of metal catalysts such as palladium catalysts, and the structural framework of the target molecule is constructed in one step. By adjusting the reaction conditions, such as temperature, reaction time, catalyst dosage, etc., the yield and selectivity of the reaction are optimized to achieve the purpose of efficient synthesis of 3-methoxy-6- (trifluoromethyl) pyridine-2-formaldehyde.

I don't know if 3-methoxy-6- (trifluoromethyl) pyridine-2-formaldehyde is in the market price range. This compound is very familiar, and its price is easily influenced by many factors.
First, purity is the key factor. If the purity is very high, it reaches the scientific research level, and the impurities are strictly controlled, the price will be high; if the purity is slightly lower, it is suitable for general industrial use, and the price may be relatively low.
Second, the market supply and demand relationship has a great impact. If the demand is strong and the supply is limited, such as the sudden increase in demand for some specific pharmaceutical research and development, the output will be difficult to keep up in time, and the price will rise; conversely, if the supply exceeds the demand, the price may fall.
Third, the complexity of the preparation process also affects the price. If the synthesis of this compound requires cumbersome steps, special raw materials or harsh reaction conditions, the cost will increase, and the price will rise.
Fourth, the production scale has an impact. In large-scale production, due to the scale effect, the unit cost may be reduced, and the price may be favorable; in small-scale production, the unit cost is higher, and the price will also be higher.
However, I have not retrieved the exact price range information. If you want to know the details, you can consult chemical raw material suppliers, relevant chemical trading platforms, or industry insiders at chemical industry forums. They may be able to provide a more accurate price range.

3-Methoxy-6- (trifluoromethyl) pyridine-2-formaldehyde is an organic chemical substance. Its storage conditions are crucial to the quality and stability of this substance.
This substance should be stored in a cool and dry place. In a cool place, the temperature should not be too high, because high temperature can easily cause chemical reactions or structural changes, losing its inherent nature. If it is in a very hot environment, its molecular activity increases greatly, or triggers reactions such as decomposition and polymerization, resulting in quality deterioration.
A dry environment is also indispensable. Moisture easily interacts with the substance, or causes it to hydrolyze, generate impurities, and damage its purity. In order to store, when there are good moisture-proof facilities, such as the placement of desiccant, it can absorb the surrounding moisture and keep it dry.
Furthermore, the storage place should be away from fire sources and oxidants. This substance may be flammable, and it will be dangerous in case of open flames or hot topics; and oxidants can also react violently with it, causing accidents. Therefore, it needs to be isolated from fire sources, oxidants, etc., to ensure the safety of storage.
Also pay attention to the choice of storage containers. Corrosive-resistant materials should be used to prevent the container from reacting with substances and affecting its quality. And the container should be well sealed to prevent it from contacting with outside air, moisture, etc.
In this way, the storage conditions of 3-methoxy-6- (trifluoromethyl) pyridine-2-formaldehyde can be kept in a cool, dry, fireproof, oxidizer-proof and suitable container.