3-methoxy-4-nitropyridine 1-oxide

3-Methoxy-4-nitropyridine-1-oxide is one of the organic compounds. It has unique chemical properties and has a wide range of uses in the field of organic synthesis.
Looking at its chemical structure, the structure of methoxy (-OCH) and nitro (-NO 2O) and pyridine-1-oxide gives it specific reactivity. Methoxy has the effect of electron supply, which can change the electron cloud density on the pyridine ring, affecting the molecular reaction check point and reactivity. Nitro is a strong electron-absorbing group, and the coexistence of the two gives the molecular electron distribution a unique situation.
Regarding chemical properties, the nitrogen atom on the pyridine ring is oxidized to N-oxide, which increases the electron cloud density of the pyridine ring and improves the activity of nucleophilic substitution. Under appropriate conditions, the methoxy group or nitro group can be substituted. Methoxy can be replaced by other nucleophiles, while nitro can be reduced to amino groups and other groups, which are commonly used in organic synthesis.
In addition, 3-methoxy-4-nitropyridine-1-oxide can participate in cyclization reactions under specific conditions to construct more complex cyclic compounds. Due to its unique electronic structure and reactivity, it is often an important intermediate in the synthesis and preparation of fine chemicals such as pharmaceuticals and pesticides, providing an effective way to create novel compounds and promoting the development of the field of organic synthetic chemistry.

The common synthesis methods of 3-methoxy-4-nitropyridine-1-oxide are as follows.
First, pyridine-1-oxide is used as the starting material. Before the appropriate reaction conditions, pyridine-1-oxide meets the nitrogenation reagent. Commonly used nitrogenation reagents, such as the mixed acid of nitric acid and sulfuric acid. Under the action of this mixed acid, a nitro group can be introduced into the pyridine ring of pyridine-1-oxide at a specific position to generate 4-nitropyridine-1-oxide. Then, 4-nitropyridine-1-oxide is reacted with a methoxylation reagent. Commonly used methoxylation reagents include the combination of iodomethane and potassium carbonate. Under suitable solvents and reaction conditions, specific groups in 4-nitropyridine-1-oxide can be replaced by methoxy groups, and finally 3-methoxy-4-nitropyridine-1-oxide is obtained.
Second, starting from 3-methoxy-pyridine. First, 3-methoxy-pyridine is oxidized and converted into 3-methoxy-pyridine-1-oxide. The oxidizing reagent can be selected from m-chloroperoxybenzoic acid, etc. After that, the nitrogenation reaction is carried out on 3-methoxypyridine-1-oxide. Using suitable nitrogenation reagents, under appropriate reaction conditions, nitro groups can be introduced at the fourth position of the pyridine ring to prepare 3-methoxy-4-nitropyridine-1-oxide.
Third, 4-nitropyridine is used as the starting material. First, 4-nitropyridine is oxidized to 4-nitropyridine-1-oxide. After that, it is methoxylated. Select appropriate methoxylation reagents and reaction conditions to achieve the synthesis of 3-methoxy-4-nitropyridine-1-oxide.
All synthesis methods have their own advantages and disadvantages, which need to be weighed according to the actual reaction conditions, availability of raw materials and purity requirements of the target product.

3-Methoxy-4-nitropyridine-1-oxide has a wide range of uses. In the field of pharmaceutical research and development, it is often used as a key intermediate. Geinpyridine-N-oxide has a unique structure and can be derived from other compounds through many chemical reactions, which is of great significance for the synthesis of drugs with specific biological activities. For example, in the process of creating antibacterial drugs, it can be modified and modified according to its structural characteristics, so that the obtained new compounds can inhibit or kill specific bacteria, contributing to the fight against infectious diseases.
It is also used in the field of materials science. Some of its derivatives may have special electrical and optical properties and can be used to prepare organic semiconductor materials. Such materials can be used in the manufacture of organic Light Emitting Diodes (OLEDs), organic field effect transistors (OFETs) and other devices to optimize device performance, such as improving luminous efficiency, enhancing electron transmission capacity, and contributing to the development of new electronic devices.
In the field of pesticides, 3-methoxy-4-nitropyridine-1-oxide is also useful. After rational structural modification, new pesticides may be developed. If it has repellent or poisoning effects on specific pests, and is more environmentally friendly than traditional pesticides, it has less residues and less harm to non-target organisms, which is of great significance for sustainable agricultural development.
Furthermore, in chemical synthesis research, it can be used as a reaction reagent or catalyst to promote specific organic reactions. With its electronic effect and steric resistance characteristics, it guides the reaction in the desired direction, improves reaction selectivity and yield, and provides an effective tool for the development of organic synthesis chemistry.

3-Methoxy-4-nitropyridine-1-oxide is a kind of organic compound. Its physical properties are quite important and are related to many practical applications.
The properties of this compound are mostly solid at room temperature, the texture may be crystalline, and the appearance is often white to light yellow, which is quite unique. Its melting point is an important physical parameter, which is about a specific temperature range. At this temperature, the substance changes from solid to liquid, and this property is crucial for its separation, purification and application.
Furthermore, solubility is also a significant physical property. In organic solvents, such as common ethanol, ether, etc., it has a certain solubility, but its solubility in water is relatively limited. This difference in solubility can be used to select suitable solvents in chemical experiments and industrial production to achieve the purpose of dissolution, extraction, and reaction.
Its density is also the main point to consider. The relative density determines its position and distribution in the mixed system, which has a great influence on the design and operation of related chemical processes. In addition, its stability also varies under different environmental conditions. It is relatively stable at room temperature and pressure without the presence of special chemical reagents. However, when it encounters extreme conditions such as strong acid, strong base, or high temperature, or chemical reactions occur, causing its structure and properties to change. The physical properties of 3-methoxy-4-nitropyridine-1-oxide, from appearance, melting point, solubility to density and stability, are interrelated and together form the whole of its physical properties. It plays an indispensable role in chemical research, industrial production and related fields.

What you are asking is the market price of 3-methoxy-4-nitropyridine-1-oxide. However, the price of this chemical often changes for many reasons, and it is difficult to determine the exact number.
First, the supply and demand situation in the market has a great impact on its price. If there are many people who want it, and the supply is small, the price will increase; if the supply exceeds the demand, the price may drop. Second, the price of raw materials is also related. This chemical requires all kinds of raw materials, and the price of raw materials will rise and fall, which will affect the price of finished products. Third, the manufacturing cost cannot be ignored. The cost of manpower, equipment, venues, etc. is included in the manufacturing cost. If the cost is high, the price will be high, and if the cost is low, the price may be reduced. Fourth, the state of market competition is also the key. If there are many manufacturers in the city and the competition is fierce, it is for customers, or there is a price reduction; if there are few manufacturers, the competition will be slow, and the price may rise steadily.
And the price of this chemical varies in different places and at different times. Or in prosperous cities, the price is different from that in remote places due to transportation, taxation, etc.; or in different seasons, due to seasonal factors and policy changes, the price is also different.
Therefore, in order to know the exact market price of 3-methoxy-4-nitropyridine-1-oxide, it is necessary to check the chemical market conditions in detail, consult the supplier, or visit the chemical trading platform to obtain a more accurate price.