3-Iodo-2-propoxypyridine

3-Iodine-2-propoxypyridine is also an organic compound. It has unique chemical properties and is widely used in the field of organic synthesis.
In terms of its physical properties, it is mostly solid or liquid at room temperature, depending on its purity and environmental conditions. Parameters such as its melting point and boiling point are the keys to define its physical properties. For melting point, the temperature at which a substance changes from solid to liquid state, and the boiling point is the temperature at which it changes from liquid to gas state. The two vary depending on the intermolecular forces.
In terms of chemical properties, iodine atoms are active and easily participate in substitution reactions. Due to the electronegativity and atomic radius characteristics of iodine, the pyridine ring and propoxy group in the ortho position are affected by it. Pyridine rings are aromatic, electron-rich, and can react with electrophilic reagents. Propoxy can form coordination bonds with metal ions or participate in nucleophilic substitution reactions due to the lone pair of electrons of the oxygen atom.
Its reactivity is manifested in many chemical reactions. For example, in palladium-catalyzed cross-coupling reactions, iodine atoms can react with other organoboronic acids or halogenated hydrocarbons to form carbon-carbon bonds, which is a common means for synthesizing complex organic molecules. Furthermore, the oxygen atom of the propoxy group can be used as a nucleophilic check point to react with halogenated hydrocarbons or acyl halides to derive a variety of derivatives. < Br >
Because the pyridine ring contains nitrogen atoms, it is weakly basic and can react with acids to form salts. This property is of great significance in regulating its solubility and reactivity.
The rich chemical properties of 3-iodine-2-propoxypyridine provide many possibilities for organic synthesis chemists, and have important application potential in drug development, materials science and other fields.

The common synthesis methods of 3-iodine-2-propoxypyridine include the following.
One is to use 2-hydroxypyridine as the starting material. First, 2-hydroxypyridine is reacted with a propylation reagent, such as propyl halide (propyl chloride, propyl bromide, etc.) under alkaline conditions. The base can be selected from potassium carbonate, sodium hydroxide or the like. This reaction goes through a nucleophilic substitution process. The oxygen of the hydroxyl group attacks the carbon atom of the propyl halide, and the halogen ions leave to form 2-propoxypyridine. Subsequently, 2-propoxypyridine is reacted with iodine substitutes such as iodine and N-iodosuccinimide (NIS) under appropriate conditions. If iodine is used, it is often necessary to replace the 3-position hydrogen of the pyridine ring with iodine in the presence of oxidants (such as hydrogen peroxide, nitric acid, etc.), and then 3-iodine-2-propoxypyridine is prepared.
The second is to use 3-iodopyridine as the starting material. First, the second position of 3-iodopyridine is hydroxylated, and the lithium pyridine intermediate can be formed by reacting with a strong basic reagent (such as butyl lithium, etc.), and then reacting with a suitable oxygen source (such as carbon dioxide, ethylene oxide, etc.) to introduce hydroxyl groups. Then, 3-iodopyridine is obtained by hydrolysis and other steps. Then, as in the subsequent propylation step using 2-hydroxypyridine as a raw material, it is reacted with the propylation reagent under basic conditions to finally synthesize 3-iodopyridine.
Another method is to use pyridine as the initial substance. 3-Iodine-2-propoxypyridine can be synthesized from 3-iodine-pyridine by iodine and suitable catalysts (such as mercury chloride, etc.). 3-Iodine-pyridine is then propoxylated and reacted with propylating reagents in a basic environment to synthesize the target product 3-iodine-2-propoxypyridine. These methods have their own advantages and disadvantages, and the practical application depends on factors such as the availability of raw materials, the ease of control of reaction conditions, and the yield.

3-Iodine-2-propoxypyridine is widely used in the field of chemical synthesis. It can be used as a key intermediary in the creation of medicine. To cover the process of pharmaceutical synthesis, it is often necessary to build a specific molecular structure. Due to its unique structure, this compound can undergo various reactions, such as coupling reactions, and be named with other reagents, and then generate biologically active molecules, or be the precursor structure of new drugs. When developing antibacterial, anti-cancer and other drugs, it has its own potential.
In the field of materials science, it also has potential uses. For example, in the preparation process of organic electronic materials, it can be used to participate in reactions and introduce specific functional groups to regulate the electronic properties of materials, such as electrical conductivity and optical properties. With this, luminescent materials with excellent performance can be created and used in devices such as organic Light Emitting Diodes (OLEDs), so that display technology can be improved.
Furthermore, in the field of pesticide chemistry, it is also possible. After rational molecular design and modification, this can be used as a starting material, or high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be synthesized. Through the relationship between its structure and biological activity, highly targeted pesticides can be designed for specific pests and diseases, improving the use efficiency of pesticides and reducing the adverse effects on the environment.
In summary, 3-iodine-2-propoxypyridine has important application value in many fields such as medicine, materials, and pesticides, providing a key chemical basis for the development of many fields.

The price of 3-iodine-2-propoxypyridine is difficult to determine in the current market. Because the market situation is unstable, the price varies with many factors.
First, the supply and demand situation has a great impact. If there are many people who want it, and the supply is small, the price will increase; on the contrary, if the supply exceeds the demand, the price will fall.
Second, the difficulty of preparation is also the key. The preparation process of this substance may be complex or simple, and the materials used may be easy or difficult, all of which are related to the cost, which in turn affects the selling price. If the preparation requires rare materials, or the process is complicated, the cost will be high, and the price will be high; if the material is easy to obtain and the process is simple, the price may be close to the people.
Third, the trend of market competition should not be underestimated. The number of merchants in the city and the intensity of competition are all related to price. If there are many merchants, the competition drama is for customers, or there is a move to reduce prices; if there are few merchants, there is little competition, and the price may be high.
Fourth, changes in the current situation also affect the price. Such as natural disasters, man-made disasters, and policy changes, can cause market turmoil, affect the supply and demand of this substance, and cause price fluctuations.
However, if you want to know the specific price, you should carefully check the chemical product trading platform or consult the industry experts to obtain a more accurate figure to clarify the approximate market price.

3-Iodine-2-propoxypyridine is an organic compound, and its storage conditions are very critical, which is related to the stability and quality of the substance. When this compound is stored, the first environment is dry. Because it is easy to cause many adverse reactions in contact with water and cause deterioration, it should be placed in a dry place, away from water sources, to prevent moisture.
Furthermore, temperature is also an important factor. It is best to store in a cool environment, usually 2-8 ° C. Excessive temperature may cause it to evaporate and decompose faster, reducing purity and quality; too low temperature, although it has a slight impact on stability, may change the state of the substance and cause inconvenience to access.
The choice of storage container should not be ignored. Containers with good sealing should be selected, glass or specific plastic containers are more suitable. Glass containers are chemically stable and do not easily react with compounds; specific plastic materials have good corrosion resistance and sealing. Before use, make sure that the container is clean, dry, and free of impurities.
In addition, 3-iodine-2-propoxypyridine is sensitive to light, and light may cause photochemical reactions to occur, which affects quality. Therefore, when storing, it needs to be protected from light. It can be placed in a brown bottle or stored in a dark place without direct light.
At the same time, the storage place should be well ventilated. Even if the compound is stored in a sealed container, it may still have a small amount of volatilization. Good ventilation can discharge volatile gases in time to avoid the accumulation of harmful gases and reduce safety risks. And the storage place should be away from fire sources, oxidants, etc., because of its violent reaction with these substances, which may cause danger.
In summary, 3-iodine-2-propoxypyridine should be stored in a dry, cool, dark and well-ventilated place, in a suitable sealed container, away from fire sources and oxidants, so as to ensure its stability and quality during storage.