3-Hydroxypyridine N-oxide

3-Hydroxypyridine-N-oxide, a particularly important chemical substance, is widely used in various fields.
First, in the field of medicine, it is often a key intermediate in drug synthesis. Because of its unique structure, it has specific chemical activities and pharmacological properties, and can be constructed through a series of chemical reactions. For example, in the process of developing innovative drugs for the treatment of cardiovascular diseases and neurological diseases, 3-hydroxypyridine-N-oxide is often used as a starting material or key structural fragment. Through clever organic synthesis strategies, it is introduced into the target drug molecular structure to endow the drug with specific activity and efficacy.
Second, in the field of materials science, it also plays an important role. Because it can coordinate with a variety of metal ions, it can be used to prepare functional coordination polymer materials. Such materials exhibit excellent performance in gas adsorption, ion exchange, catalysis, etc. For example, in gas adsorption, it can selectively adsorb specific gas molecules, which is expected to be applied to practical scenarios such as air purification and gas separation; in the field of catalysis, as a ligand and metal center synergistic effect, it can efficiently catalyze a variety of organic reactions, improving reaction efficiency and selectivity.
Third, in the field of organic synthesis chemistry, 3-hydroxypyridine-N-oxide is an extremely useful reagent. It can participate in a variety of classical organic reactions, such as nucleophilic substitution reactions, oxidation reactions, etc., providing an effective way to construct complex organic molecular structures. By rationally designing reaction routes and using its special structure, it can achieve some chemical bond construction that is difficult to achieve by conventional methods, thereby expanding the boundaries of organic synthesis and assisting the creation and development of new organic compounds.
In summary, 3-hydroxypyridine-N-oxide, with its unique chemical structure, plays an indispensable and important role in many key fields such as medicine, materials science, and organic synthesis, promoting the sustainable development and innovation of related fields.

3-Hydroxypyridine-N-oxide is an organic compound. Its physical properties are quite characteristic, let me tell you in detail.
Looking at its appearance, at room temperature, it is mostly white to light yellow crystalline powder. This form has its characteristic significance in many chemical reactions and practical applications.
When it comes to melting point, it is about a specific temperature range. The melting point is also the critical temperature at which a substance changes from a solid state to a liquid state. The melting point of 3-hydroxypyridine-N-oxide gives it a clear limit in the process of thermal change. In chemical preparation, purification and other links, this melting point parameter is crucial and can provide an accurate basis for controlling the reaction conditions.
Solubility is also one of its important physical properties. It has a certain solubility in water, but it is not completely soluble. This property affects the degree and rate of participation in the reaction in the reaction system involving the aqueous phase. And in organic solvents, it also exhibits a specific solubility behavior. Different organic solvents interact differently with 3-hydroxypyridine-N-oxide due to differences in molecular structure and polarity, resulting in different dissolution effects.
Furthermore, its density also has a specific value. Density reflects the mass per unit volume of a substance, and this physical quantity is of great significance in practical operations such as material storage and transportation. Knowing its density, the container volume can be reasonably planned to ensure the safety and efficiency of material storage and handling.
In addition, 3-hydroxypyridine-N-oxide may have a specific odor. Although the description of the odor or your mileage may vary, its unique odor is also part of its physical properties, which cannot be ignored in some odor-sensitive application scenarios.
In summary, the physical properties of 3-hydroxypyridine-N-oxide, such as appearance, melting point, solubility, density, odor, etc., are interrelated and jointly determine its behavior and application in the chemical field and related industries.

3 - Hydroxypyridine + N - oxide is a kind of organic compound. The chemical properties of this compound are related to its stability, which is of great concern to many people.
In the field of chemistry, the stability of a compound often depends on its molecular structure, chemical bond energy and surrounding chemical environment. In the molecular structure of 3 - Hydroxypyridine + N - oxide, the pyridine ring has a conjugated system, which can cause electron cloud dispersion and increase its stability. And the hydroxyl group and the N - oxide part also participate in the intramolecular interaction. Hydroxyl groups can be connected to surrounding molecules or other parts of their own molecules by hydrogen bonds. Although the force of hydrogen bonds is not strong, it can significantly affect its stability in molecular aggregates or solution environments. The N-oxide part, because the oxygen atom on the nitrogen atom is electron-absorbing, can change the electron cloud distribution of the pyridine ring, which in turn affects the stability of the whole molecule.
In common chemical environments, 3-Hydroxypyridine + N-oxide is stable if it is in a neutral or weakly acidic environment. However, in case of strong acid, the N-oxide part may be protonated, resulting in changes in the molecular structure and decreased stability. In an alkaline environment, the hydroxyl group may protonate to form a corresponding negative ion. The stability of this negative ion state is also different from that of the neutral molecular state, or changes due to the interaction with surrounding cations.
Furthermore, temperature is also one of the factors affecting its stability. When the temperature increases, the thermal motion of the molecule intensifies, or the vibration of the chemical bond within the molecule increases. When the vibration energy reaches a certain level, the chemical bond may be at risk of breaking and the stability decreases. On the contrary, the low temperature environment can weaken the thermal motion of the molecule, which helps to maintain its structural stability.
In summary, the chemical stability of 3 - Hydroxypyridine + N - oxide is not static, but is influenced by various factors. Under different conditions, its stability varies.

There are several methods for synthesizing 3-hydroxypyridine-N-oxide.
One is to use pyridine as the initial raw material. First, pyridine is oxidized, and peroxides such as hydrogen peroxide are often used as oxidants. Under suitable reaction conditions, pyridine nitrogen atoms are oxidized to form pyridine-N-oxide. Subsequently, pyridine-N-oxide is hydroxylated. This hydroxylation step can be achieved by various means, such as reacting with hydroxyl-containing reagents in the presence of specific catalysts. Common catalysts such as metal salts or metal complexes, and hydroxyl-containing reagents can be water and some alcohol derivatives. After this series of reactions, 3-hydroxypyridine-N-oxide can be obtained.
Second, a suitable substituted pyridine derivative can be selected as the starting material. If the derivative has a group that can be converted into a hydroxyl group at a suitable position, and the pyridine nitrogen atom is also easy to oxidize. First, the pyridine nitrogen atom is oxidized by the above-mentioned method of peroxide oxidation. Then, the substituent is converted into a hydroxyl group through a specific chemical reaction. For example, if the substituent is a halogen atom, the halogen atom can be replaced by a hydroxy- containing nucleophilic reagent through a nucleophilic substitution reaction to generate 3-hydroxypyridine-N-oxide.
Furthermore, some special organic synthesis strategies can be utilized. For example, the pyridine ring structure is constructed by cyclization reaction, and the hydroxyl group and N-oxide structure are introduced at the same time. For example, using nitrogen-containing and carbon-containing compounds as raw materials, under suitable reaction conditions and catalysts, pyridine rings are first cyclized to form. During the cyclization process or in subsequent steps, hydroxyl groups and N-oxide groups are introduced to obtain the target product 3-hydroxypyridine-N-oxide. Each synthesis method requires careful regulation of reaction conditions, such as temperature, pressure, reactant ratio, and catalyst dosage, to achieve higher yield and purity.

3-Hydroxypyridine-N-oxide is in the market, and its price range is difficult to determine. The price of this product often changes due to various factors. The purity and heterogeneity of its quality is the key to the price. Those who are of high quality and purity will have a high price; if the quality is inferior and heterogeneous, the price will be low.
In addition, the amount of production also affects its price. If the production is abundant and sufficient, the price may stabilize and level; if the production is scarce and scarce, the price will rise. Market demand also affects its price. If the industry is competing for purchases, the demand will exceed the supply, and the price will rise; if the demand is too small and no one will pay attention, the price will fall.
Furthermore, the amount of purchase is also related to the price. Buy in bulk, trade or give a discount, and the price can be slightly reduced; if you buy a little at zero, the price is as usual. In the past, the price of such chemicals ranged from tens to hundreds of yuan per kilogram. However, today's market conditions change, if you want to know the exact price, you should consult a chemical material dealer or visit a professional chemical trading platform to get a real-time and accurate price.