3-Hydroxypyridine-4-carboxylic acid methyl ester

Methyl 3-hydroxypyridine-4-carboxylate has a wide range of uses. In the field of medicine and chemical industry, it can be an important intermediate in organic synthesis. From the perspective of drug research and development, with its unique chemical structure, it can be used to construct specific active drug molecular structures, and then lay the foundation for the creation of new drugs. In the synthesis of some compounds with specific pharmacological activities, it is often used as a key starting material, and it undergoes a series of chemical transformations to endow the target drug with the required biological activity and pharmacological properties.
In the field of materials science, it also has potential application value. Or can participate in the preparation of functional materials, for example, when synthesizing materials with specific optical, electrical or adsorption properties, they are introduced as structural units to change the microstructure and properties of the materials, so that the materials meet the special needs of different fields.
In the field of scientific research and exploration, the coexistence of hydroxyl groups, ester groups and pyridine rings in the structure provides a good model for the study of organic chemistry mechanisms. Researchers can use various chemical reactions to conduct various chemical reactions on them to further explore basic chemical issues such as reaction mechanisms and optimization of reaction conditions, and promote the development of organic chemistry theory and practice.

Methyl 3-hydroxypyridine-4-carboxylate is one of the organic compounds. Its physical properties are very important, and it is related to many characteristics and uses of this compound.
Looking at its properties, under room temperature and pressure, it is mostly solid, or white to light yellow crystalline powder. This appearance feature is easy to identify and preliminarily determine.
When it comes to melting point, it is usually in a specific temperature range, which is of great significance for determining its purity and state transition under different conditions. The specific melting point value is roughly in a certain range due to different preparation methods and purity differences, and can be accurately determined by experiments.
In terms of solubility, it has different manifestations in common organic solvents. For example, in polar organic solvents such as methanol and ethanol, it has a certain solubility. This property is conducive to the dissolution, separation and purification of reactants or products in organic synthesis and related chemical reactions. In water, the solubility is relatively limited, but under certain conditions, by adjusting the pH value and other means, the solubility may change.
The boiling point is also a key physical property. Under a specific pressure, it will boil at a certain temperature. The boiling point value reflects the strength of intermolecular forces, which is directly related to its stability and volatility under high temperature conditions. Knowing the boiling point is crucial in the separation process such as distillation and rectification, so as to achieve effective separation from other substances.
Density is also a physical property that cannot be ignored. Although its density data is often ignored, in many practical application scenarios, such as in the process of solution preparation and phase separation, accurate knowledge of density is indispensable for calculating the amount of substances and determining the proportion of the mixed system.
In addition, its optical properties at specific wavelengths, such as ultraviolet absorption, also have unique manifestations. This property can be used in the field of analytical chemistry for content determination, purity detection, etc. Detected by ultraviolet-visible spectrometer, characteristic absorption peaks can be obtained, providing a basis for qualitative and quantitative analysis.

The synthesis methods of 3-hydroxypyridine-4-carboxylic acid methyl ester have been explored by many scholars in the past, and now the number of common ones are described.
First, methyl pyridine-4-carboxylate is used as the starting material and can be obtained by selective hydroxylation reaction. In this method, it is crucial to select an appropriate hydroxylation reagent. For example, a strong oxidant is used to oxidize the hydrogen on the pyridine ring under specific conditions to promote its conversion to hydroxyl groups. However, this process requires fine regulation of the reaction conditions. Due to the high activity of strong oxidants, it is easy to cause excessive oxidation, and many by-products are formed, which affects the purity and yield of the products.
Second, the pyridine derivative containing the corresponding substituent group is used as the substrate, and it is obtained through a series of reactions to gradually build functional groups. For example, carboxyl groups are introduced first, and then hydroxylated at specific positions of the pyridine ring, and finally esters are formed. Although this path is slightly complicated, the selectivity of each step is easy to control, which can effectively improve the purity and yield of the product. However, the reaction conditions of each step vary greatly, and careful switching is required, and the experimental operation skills are also high.
Third, it can be started from natural products containing pyridine skeletons or other easily available compounds, and chemically modified. Natural products have unique structures and specific activities and selectivity. Using this as a raw material, through clever chemical transformation, the target product can be efficiently obtained. However, obtaining natural products may be limited by resources, and their structures are complex, and the modification reaction may require multiple steps and harsh conditions.
Synthesis of 3-hydroxypyridine-4-carboxylic acid methyl ester has its own advantages and disadvantages, and it is difficult to say which is better or worse. Experimenters need to carefully choose the appropriate synthesis path according to their own experimental conditions, availability of raw materials, and requirements for product purity and yield.

I look at the "3 - Hydroxypyridine - 4 - carboxylic acid methyl ester" you are inquiring about, this is a chemical substance, the Chinese name is or 3 - hydroxypyridine - 4 - carboxylic acid methyl ester. As for its market price, it is difficult to determine. Because the market price is like a flow wave, it often changes with many factors.
First, the price of raw materials has a great impact. If the source of raw materials required for the synthesis of this substance is scarce, or its production is disturbed by natural times, geography, politics and economics, the price will fluctuate. If the raw material production area encounters disasters and the output decreases, the cost will rise, and the price of this methyl ester will also rise.
Second, the complexity of the preparation process is related to cost. If the process is exquisite and complex, high-end instruments, harsh conditions and multiple processes are required, manpower and material resources are consumed, and the price is high. If the process is improved, the efficiency increases and the cost decreases, the price may also fall.
Third, market supply and demand are the key. If the demand for this methyl ester in the fields of medicine and chemical industry is strong, but the supply is limited, the price will rise. On the contrary, if the supply exceeds the demand, the manufacturer will sell the goods, or compete at a reduced price.
Fourth, manufacturers and brands are also different. Famous factories focus on quality and control standards, and the product may be expensive; new factories may compete for the market and attract customers at a low price.
From the perspective of "Tiangong Kaiwu", the price of all things is due to the difficulty of creation and the need for use. Although the price of this 3-hydroxypyridine-4-carboxylate methyl ester has not been detailed in ancient books, the changes in the market today are also based on supply and demand and cost. To know its exact price, it is advisable to consult the merchants in the chemical raw material market and check the industry information platform to get a more accurate number.

For methyl 3-hydroxypyridine-4-carboxylate, various matters should be paid attention to during storage and transportation. Its chemical properties are lively and it is afraid of heat, light and moisture. Therefore, when storing, it is advisable to choose a cool, dry and well-ventilated place, away from fire and heat sources. The container must be sealed to prevent moisture and air from intruding and causing it to deteriorate.
During transportation, caution should also be taken. The substance may pose a certain chemical risk and must be acted in accordance with the relevant regulations on the transportation of hazardous chemicals. The packaging should be strong and sealed to prevent leakage. The transportation vehicle should be equipped with corresponding fire and emergency treatment equipment to prevent accidents.
Furthermore, this product may be potentially harmful to human beings and the environment. During handling, storage and transportation, operators must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to avoid direct contact. In case of accidental leakage, emergency measures should be taken immediately to isolate the contaminated area to prevent spread, collect and clean up the leakage in a proper manner, and do not let it enter the environment and cause ecological damage. In this way, it is necessary to ensure the safety of methyl 3-hydroxypyridine-4-carboxylate during storage and transportation.