3-hydroxypyridine-2-carboxylate

The chemical structure of 3-hydroxypyridine-2-carboxylate is composed of a pyridine ring as a group, and a hydroxyl group and a carboxylate group are connected at a specific position on it.
The pyridine ring is a nitrogen-containing six-membered heterocyclic ring with aromatic properties, stable structure and unique chemical properties. In 3-hydroxypyridine-2-carboxylate, the pyridine ring is the molecular skeleton, which lays the foundation for its basic configuration and reactivity.
Hydroxy (-OH) is attached to the third position of the pyridine ring. Hydroxyl groups are hydrophilic and can participate in the formation of hydrogen bonds. They play an important role in the interaction between molecules or molecules and solvents. Its electronic effect also affects the electron cloud distribution of the pyridine ring, which changes the electron density at specific positions of the pyridine ring, which in turn affects the reactivity and chemical properties of the molecule. For example, hydroxyl groups can increase the density of electron clouds in adjacent and para-sites, and electrophilic substitution reactions are prone to occur at these locations.
Carboxylate groups (-COO) are attached to the second position of the pyridine ring. The carboxylate form imparts ionic properties to the molecule, increasing its solubility in polar solvents such as water. Carboxylate groups can also participate in a variety of chemical reactions, such as complexing with metal ions to form metal complexes, which is of great significance in the fields of catalysis, materials science, etc. Its negative charges can interact with positively charged species to build supramolecular structures. The chemical structure of 3-hydroxypyridine-2-carboxylate exhibits unique physical and chemical properties through the interaction of various groups, and has potential application value in many fields such as medicinal chemistry, coordination chemistry, and materials science.

3-Hydroxypyridine-2-carboxylate is a kind of organic compound. Its physical properties are described in detail as follows.
Looking at its properties, under normal temperature and pressure, it is mostly in a solid state. The formation of this state is due to the force between molecules, so that the molecules are arranged in an orderly manner, forming a stable shape. Its color is often white or off-white, like early winter snow, pure and free of impurities. This color also reflects the relative regularity of its structure, and impurities are rare.
As for the melting point, it varies depending on the specific salts. However, the approximate range is mostly within a certain range. The melting point is closely related to the strength of the chemical bonds within the molecule and the size of the intermolecular forces. If the chemical bonds are strong and the intermolecular interaction is large, more energy is required to break the structure, and the melting point is high; otherwise, it is low.
In terms of solubility, in water, it has a certain solubility. Because the molecule contains polar groups, it can interact with water molecules to form hydrogen bonds, etc., so that it can be dispersed in water. However, the solubility is not infinite. When the solution reaches the solution equilibrium, the solution is saturated. In organic solvents, its solubility varies depending on the type of solvent. Polar organic solvents, because they are similar to the polarity of the compound, have good solubility according to the principle of "similar compatibility"; non-polar organic solvents, which are contrary to their polarity, have limited solubility. < Br >
In addition, its density is also one of the important physical properties. The value of density reflects the mass of the substance per unit volume. This value is related to the mass of the molecule and the degree of close arrangement between molecules. If the molecular weight is large and the arrangement is close, the density will be higher; if it is not, it will be lower.
Furthermore, the stability of the compound is also a consideration of physical properties. Under normal conditions, its structure is relatively stable and not prone to spontaneous changes. In case of extreme conditions such as high temperature, strong acid, and strong base, its chemical bonds may be affected, and the structure may also change, and the stability may be lost.
In summary, the physical properties, properties, melting point, solubility, density and stability of 3-hydroxypyridine-2-carboxylate are determined by its molecular structure and composition, and under different conditions, the properties also change.

The common uses of 3-hydroxypyridine-2-carboxylate are mostly related to many fields. In the field of medicine, because of its specific chemical structure and properties, it can be used as a key intermediate in drug synthesis. Through subtle chemical transformation, compounds with unique pharmacological activities can be derived, or have antibacterial, anti-inflammatory and even anti-tumor effects, providing new opportunities and ways for the treatment of diseases.
In the field of materials science, it can also be used. Or it can participate in the construction of functional materials, such as ingeniously coordinating with metal ions to form coordination polymers with unique structures and excellent properties. Such polymers may emerge in gas adsorption and catalysis, such as efficient adsorption of specific gas molecules, or as catalysts to accelerate specific chemical reactions and improve reaction efficiency and selectivity.
In the field of agriculture, 3-hydroxypyridine-2-carboxylate may be used as a plant growth regulator. Moderate application may affect the growth and development process of plants, such as promoting seed germination and making seedlings more robust; or regulating plant hormone balance, enhancing plant resilience to adversity (such as drought, salinity, etc.), and helping crops to produce and increase income.
In addition, in the field of chemical analysis, because of its unique coordination ability and color rendering characteristics for specific metal ions, it can be developed as a metal ion detection reagent. With the help of visual phenomena such as color changes, the presence and content of specific metal ions in environmental and biological samples can be detected sensitively and accurately, providing convenient and effective analysis methods for environmental monitoring and biomedical diagnostics.

The method of preparing 3-hydroxypyridine-2-carboxylate has been known for a long time, and is described in detail below.
First, 3-hydroxypyridine-2-carboxylic acid is used as the starting material, which can be reacted with alkali metal hydroxide. For example, 3-hydroxypyridine-2-carboxylic acid is placed in a reactor, and an aqueous solution of sodium hydroxide is slowly added. The temperature is controlled within an appropriate range, generally between room temperature and 50 ° C. When stirred for a number of times, the two are fully reacted. Because 3-hydroxypyridine-2-carboxylic acid is acidic, it can be neutralized with sodium hydroxide to generate the corresponding 3-hydroxypyridine-2-carboxylate sodium salt. After the reaction is completed, it is concentrated under reduced pressure to remove water, and then washed with appropriate organic solvents, such as ethanol and acetone, to obtain pure 3-hydroxypyridine-2-carboxylate sodium.
Second, 3-hydroxypyridine can also be used as raw material and prepared by carboxylation reaction. First dissolve 3-hydroxypyridine in a suitable solvent, such as N, N-dimethylformamide (DMF), add a base, such as potassium carbonate, and stir well. Then add carbon dioxide gas, raise the temperature to 80-120 ° C, and the reaction number is time. In this process, the alkali captures the hydrogen of 3-hydroxypyridine to form a carbon anion, which is nucleophilic addition to carbon dioxide to form a 3-hydroxypyridine-2-carboxylic acid intermediate, which is then reacted with the alkali in the system to convert into 3-hydroxypyridine-2-carboxylate. After the reaction is completed, it is cooled, filtered, and the filtrate is concentrated and recrystallized in an organic solvent to obtain the target product.
Third, 2-chloro-3-hydroxypyridine is used as the starting material. It is reacted with a carboxylate, such as potassium acetate, in a high-boiling solvent, such as diethylene glycol, heated to 150-200 ° C. This is a nucleophilic substitution reaction. The anion acetate replaces the chlorine atom of 2-chloro-3-hydroxypyridine to generate 3-hydroxypyridine-2-carboxylic acid ester. After hydrolysis and alkali treatment, 3-hydroxypyridine-2-carboxylate can be obtained. Subsequent separation, purification, such as extraction, crystallization and other steps can improve the purity of the product.
The above methods for preparing 3-hydroxypyridine-2-carboxylate have their own advantages and disadvantages, and they need to be used according to actual needs and conditions.

3-Hydroxypyridine-2-carboxylate is a very characteristic compound that has its own unique uses in many fields.
In the field of medicine, it shows significant potential. Because of its specific chemical structure and properties, it can be used as an intermediate for drug synthesis. With ingenious chemical modification and transformation, compounds with specific pharmacological activities can be constructed. For example, when developing targeted drugs for specific diseases, 3-hydroxypyridine-2-carboxylate can be used as a key starting material to lay the foundation for the synthesis of drugs with precise structure and exact efficacy.
In the field of materials science, it also has extraordinary performance. It can be used to prepare functional materials, such as materials with special optical and electrical properties. Due to its unique structure, it can participate in the molecular construction of materials and endow materials with novel physical and chemical properties. For example, when preparing some new photoelectric materials, adding an appropriate amount of this compound may improve the charge transport properties and luminous efficiency of materials, thereby promoting the development of related photoelectric devices.
In the field of agriculture, it also plays a certain role. It may be used as a component of plant growth regulators. Because of its chemical properties, it may affect the physiological processes of plants, such as regulating the balance of plant hormones, promoting plant root growth, enhancing plant resistance, etc., to help crops with high quality and high yield.
In the field of chemical catalysis, 3-hydroxypyridine-2-carboxylate is also used. Because it can be used as a ligand to form complexes with metal ions, such complexes exhibit good catalytic activity and selectivity in catalytic reactions. In some organic synthesis reactions, it can efficiently catalyze reactions, improve reaction efficiency and product purity, and provide a more efficient way for chemical production.