3-Hydroxymethyl-2-methylpyridine

3-Hydroxymethyl-2-methylpyridine has a wide range of uses. In the field of medicine, it is often used as a key intermediate in the creation of a variety of drugs. The particularity of the structure of the pyridine ring gives it unique chemical and biological activities, which can help build complex drug molecular structures. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, its role is indispensable.
In the field of materials science, 3-hydroxymethyl-2-methylpyridine also has a place. It can participate in the synthesis of polymer materials. After specific reactions, it can be integrated into the polymer chain to improve material properties, such as enhancing material stability and adjusting material hydrophobicity. It plays an important role in the preparation of special functional materials.
In the field of organic synthetic chemistry, it is an important synthetic building block. With the structure of hydroxymethyl and methylpyridine, many chemical reactions can be carried out, such as nucleophilic substitution, oxidation and reduction, etc., providing a foundation for the construction of diverse organic compounds, helping organic chemists explore new compound synthesis paths, and promoting the continuous development of organic synthetic chemistry. In short, 3-hydroxymethyl-2-methylpyridine has key uses in many fields due to its unique structure, which has far-reaching impact on the development of related industries.

3-Hydroxymethyl-2-methylpyridine, which is a colorless to light yellow liquid with a unique odor. Its boiling point is between 240 and 245 ° C, and it can maintain relative stability at room temperature and pressure.
When it comes to solubility, it is soluble in water and miscible with many organic solvents, such as ethanol and ether. This property makes it useful in chemical synthesis and other fields.
In terms of its density, it is about 1.05 - 1.10 g/cm ³, which is different from the density of water. This physical property needs to be paid attention to when related to separation and mixing operations. Its refractive index is in the range of 1.52 - 1.54, and its purity can be determined by the refractive index.
In addition, the flash point of 3-hydroxymethyl-2-methylpyridine is about 110 ° C. This is related to the safety of its storage and use process. When it involves fire sources or high temperature environments, it must be handled with caution to prevent accidents such as fires. In short, knowing these physical properties is of great significance in terms of its effective application and safe operation.

3-Hydroxymethyl-2-methylpyridine is an organic compound. Its shape may be colorless to pale yellow liquid, or crystalline solid, with a special odor. This substance has a wide range of uses in the field of organic synthesis, and is often used as a synthetic intermediate for pharmaceuticals, pesticides, dyes and other fine chemicals.
In terms of chemical properties, the hydroxymethyl groups in its molecules and the methyl groups on the pyridine ring give it unique reactivity. Hydroxymethyl groups have typical properties of alcohols and can participate in many reactions. For example, under appropriate conditions, esterification can occur, reacting with organic acids or inorganic acids to form corresponding ester compounds. This reaction is commonly used in organic synthesis to construct molecular structures with specific functions.
Furthermore, hydroxymethyl groups can be oxidized. With appropriate oxidant treatment, it can be oxidized to aldehyde or carboxyl groups, thereby expanding the reaction path and product type of the compound, providing the possibility for the synthesis of more complex organic molecules.
The structure of the pyridine ring also has a profound impact on its chemical properties. The nitrogen atom of the pyridine ring has a certain alkalinity and can react with acids to form salts. At the same time, the pyridine ring can participate in nucleophilic substitution reactions and electrophilic substitution reactions. In the nucleophilic substitution reaction, the hydrogen atom on the pyridine ring can be replaced by other nucleophilic reagents; in the electrophilic substitution reaction, the pyridine ring exhibits similar but different reactivity and selectivity to the benzene ring, laying the foundation for the synthesis of diverse derivatives.
In addition, although the methyl group at the 2-position is relatively stable, it can also participate in some reactions under specific reaction conditions. For example, the hydrogen atom on the methyl group can undergo substitution reactions under the action of some strong oxidants or free radical initiators, which further enriches the reaction chemistry of the compound.
In summary, 3-hydroxymethyl-2-methylpyridine exhibits diverse chemical properties due to its unique molecular structure, and has broad application potential in the field of organic synthetic chemistry. It provides abundant reaction pathways and possibilities for the synthesis of many organic compounds.

The preparation method of 3-hydroxymethyl-2-methylpyridine has been known for a long time, but the process is complicated and the materials used are very different. It is described in detail below.
First, 2-methylpyridine is used as the starting material, and hydroxymethyl is introduced through a specific reaction. First, 2-methylpyridine and a certain reagent undergo a nucleophilic substitution reaction under a specific temperature, pressure and catalyst. If a suitable reagent such as formaldehyde is used, in the alkali catalytic system, the base can be selected from sodium hydroxide, potassium hydroxide or the like to adjust the pH of the reaction system, so that the reaction proceeds in the direction of introducing hydroxymethyl. The reaction temperature is often controlled in a moderate range, about tens of degrees Celsius, and the pressure depends on the reaction requirements, or normal pressure, or slightly pressurized. After a few hours, the reaction is completed, and 3-hydroxymethyl-2-methylpyridine can be obtained after separation and purification.
Second, there is another path, starting from a compound containing a precursor of the pyridine ring. After a multi-step reaction, the structure of the pyridine ring is first constructed, and then hydroxymethyl and methyl are introduced at a specific position. This process requires precise control of the reaction conditions, involving many reaction steps such as cyclization and substitution. For example, a suitable nitrogenous and carbonaceous raw material is used to form a pyridine ring skeleton under the action of a condensation reagent, and then a methyl group is introduced through a selective methylation reaction, and then a hydroxymethyl group is introduced at the target position through a hydroxymethylation reaction. In each step of the reaction, factors such as the ratio of reactants, reaction time, and temperature must be considered to ensure the purity and yield of the product.
Third, there is also a method of biosynthesis. Using the catalytic properties of microorganisms or enzymes to synthesize 3-hydroxymethyl-2-methylpyridine through a biological metabolic pathway with a specific substrate. This biological method is relatively green and environmentally friendly, but it requires strict requirements on the reaction environment. It requires precise regulation of temperature, pH, substrate concentration and other conditions to maintain the activity of microorganisms or enzymes and promote the generation of target products. And the biosynthetic process is complex, and in-depth research on the culture and domestication of microorganisms or enzymes is required to achieve effective preparation.

3-Hydroxymethyl-2-methylpyridine is in the market, and its price range is difficult to determine. The price of this compound often varies for many reasons. First, the cost of production is the main factor. If the price of its raw materials is high, or the preparation process is complicated and expensive, its price must be high. Second, the supply and demand of the market also affect its price. If there are many people who want it, and the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price may fall. Furthermore, the quality of its quality is also related to the price, and the price of the superior is high.
Looking at the examples of past transactions, the price may vary due to different origins. And different suppliers have different pricing, or because of their business strategies and cost control. Generally speaking, in the market of chemical raw materials, the price of this compound ranges from tens to hundreds of yuan per kilogram. However, this is only a rough estimate, and the actual price depends on the current market conditions, the number of purchases and the details of the transaction. To know the exact price, you need to consult the chemical product supplier in detail, and compare the quotations of multiple companies to obtain a more suitable price.