3-HYDROXY-5-METHOXYPYRIDINE

3-Benzyl-5-methoxypyridine is a crucial intermediate in the field of organic synthesis, and is widely used in many fields such as medicine, pesticides and materials science.
In the field of medicine, it is often used as a key intermediate for the synthesis of various biologically active compounds. The structure of many drug molecules contains a pyridine ring, and the specific substituent of 3-benzyl-5-methoxypyridine can endow the drug with more ideal pharmacological activity and pharmacokinetic properties. For example, it can be converted into drugs with therapeutic effects on specific diseases through specific chemical reactions, such as the synthesis of drugs for certain inflammatory diseases and neurological diseases. This intermediate may play an important role.
In the field of pesticides, this compound can be used as a basic structural unit for building high-efficiency and low-toxicity pesticide molecules. With its unique chemical structure, the synthesized pesticides may have excellent insecticidal and bactericidal activities, and have relatively little impact on the environment. For example, for the control of specific pests, pesticides prepared with 3-benzyl-5-methoxypyridine as raw materials can precisely act on specific physiological targets of pests, achieving good control results. < Br >
In the field of materials science, it can be used to prepare functional materials. After chemical reaction, it is introduced into polymer materials, which may endow materials with special properties such as optics and electricity. For example, in the field of organic optoelectronic materials, this intermediate may be used to improve the charge transport properties of materials, and then applied to the manufacture of organic Light Emitting Diodes, solar cells and other devices.
In summary, 3-benzyl-5-methoxypyridine plays a key role in the field of organic synthetic chemistry due to its important applications in many fields, and continues to promote the development and progress of related industries such as medicine, pesticides and materials science.

3-Cyano-5-methoxypyridine is an organic compound with specific physical and chemical properties. Its appearance is usually white to light yellow crystalline powder, which is stable at room temperature and pressure.
From the perspective of physical properties, this compound has a certain melting point, about 60-65 ° C. Due to the arrangement and interaction of atoms in the molecular structure, the crystal lattice disintegrates in this temperature range and changes from a solid state to a liquid state. Its boiling point is between 280 and 290 ° C. At this time, the molecule obtains enough energy to overcome the intermolecular forces and convert from a liquid state to a gas state.
In terms of solubility, slightly soluble in water, because water is a polar solvent, while 3-cyano-5-methoxypyridine molecules have limited polarity and weak interaction with water molecules. However, it is easily soluble in common organic solvents, such as ethanol, dichloromethane, acetone, etc. Ethanol contains hydroxyl groups and can form hydrogen bonds and other interactions with the compound; the molecular polarities of dichloromethane and acetone match the compound, and according to the principle of similar miscibility, they can be well miscible.
In chemical properties, cyanyl groups have high reactivity. Hydrolysis reactions can occur, and under acidic or basic conditions, cyanyl groups are gradually converted into carboxyl or amide groups. For example, under alkaline conditions, the cyanyl group first reacts with hydroxide ions to form an amide through a series of intermediate steps, and further hydrolyzes to obtain carboxylic salts. Its methoxy group can also participate in the reaction. For example, in the nucleophilic substitution reaction, the methoxy group can be replaced by other nucleophilic reagents. Because the oxygen atom has lone pair electrons, the methoxy group becomes a good leaving group. The pyridine ring imparts a certain alkalinity to the compound and can react with acids to form salts, because the lone pair electrons on the nitrogen atom of the pyridine ring can accept protons.
In summary, the physical and chemical properties of 3-cyano-5-methoxy pyridine are determined by its unique molecular structure, and these properties are of great significance in the fields of organic

3-Hydroxy-5-methoxypyridine, this is an organic compound. The stability of its chemical properties needs to be investigated in detail.
The stability of the covering substance depends on many factors. In terms of structure, the presence of hydroxyl and methoxy groups in the molecule will affect the electron cloud distribution of the pyridine ring. Hydroxyl is the donator group, and methoxy is also the donator group. The donator effect of the two may enhance the electron cloud density of the pyridine ring. In this way, the activity of the pyridine ring may increase in the electrophilic substitution reaction, which means that its stability may decrease.
However, the pyridine ring itself has aromatic properties, and the aromatic system usually has high stability. The conjugated structure of the pyridine ring can delocalize electrons and reduce the energy of the molecule, thereby enhancing stability. And 3-hydroxy- 5-methoxypyridine molecules or there are intramolecular hydrogen bonds, if the hydrogen atom of the hydroxyl group and the oxygen atom of the methoxy group are appropriately spaced, hydrogen bonds may be formed. The existence of this hydrogen bond may increase the stability of the molecule.
In terms of the external environment, factors such as temperature, humidity, and light will also affect its stability. Under high temperature, the thermal motion of molecules intensifies, or promotes the vibration of chemical bonds. If the vibration energy is sufficient to overcome the bond energy of chemical bonds, or to cause the fracture of chemical bonds, resulting in the decomposition of substances and reduced stability. In high humidity environments, water molecules may interact with the compound or initiate reactions such as hydrolysis, which affects its stability. Under lighting conditions, if the photon energy is appropriate, or the electron transition in the molecule is excited, photochemical reactions are triggered, which pose a threat to its stability.
In summary, the chemical stability of 3-hydroxy- 5-methoxypyridine cannot be generalized. It is not only affected by its own molecular structure, but also restricted by external environmental factors.

To prepare 3-cyano-5-methoxypyridine, there are three methods.
One is to start with 5-methylpyridine-3-carboxylic acid, first heat with thionyl chloride to form acid chloride, and then react with cuprous cyanide in a suitable solvent. After cyano substitution, 3-cyano-5-methylpyridine can be obtained. Then, with appropriate reagents, such as dimethyl sulfate and base, pyridine nitrogen atom is methylated, and finally under suitable conditions, methoxy is introduced to obtain the target product. This process needs to control the reaction conditions to prevent side reactions, and cuprous cyanide is highly toxic. Use caution when using it. < Br >
Second, 3-halo-5-methylpyridine is used as raw material, and the halogen atom can be chlorine, bromine, etc. First, it reacts with sodium cyanide or potassium cyanide in the presence of a phase transfer catalyst, and reacts in a polar solvent. The halogen atom is replaced by a cyano group to obtain 3-cyano-5-methylpyridine. Subsequent to the same method, a methoxy group is introduced. Among them, the activity of halopyridine is different, and the halogen atom is selected and the reaction conditions are controlled to be heavy. The phase transfer catalyst also affects the reaction rate and yield.
Third, with suitable pyridine derivatives as substrates, cyano and methoxy groups are constructed through multi-step reactions. If methoxy is introduced first, the nucleophilic substitution reaction can be used to react with phenols and halogenated pyridine derivatives under alkali catalysis. Then an appropriate cyanide reagent, such as trimethylsilyl cyanide, is introduced under the catalysis of Lewis acid. This path is cleverly designed, but the steps are cumbersome. Each step of the reaction needs to be carefully controlled to ensure that the reaction proceeds in the desired direction and improve the total yield.
These methods have their own advantages and disadvantages. In practical application, the best path should be selected to produce 3-cyano-5-methoxypyridine according to the availability of raw materials, cost, difficulty in reaction and environmental protection.

I look at the various things in the market, and their prices depend on changes in supply and demand, the rarity of things, and the simplicity of work. As for 3-amino-5-methoxypyridine, this is a special thing, and its market price follows these principles.
If this thing is produced in large quantities in the world, the supply is abundant, and there are few people who need it, its price will become easier. However, if it is difficult to make, the methods used are complicated, it consumes a lot of man-hours and material resources, and there are many people in the world who want it, and the demand is greater than the supply, the price will be high.
Furthermore, the difficulty of obtaining its raw materials is also related to the price. If the raw materials are rare, difficult to collect, or need to be asked for, the cost will increase, which will increase the price of the product.
And the competitive situation of the market is also the key. If there are many merchants in this product, they compete with each other, or reduce the price to attract customers; if there are few merchants, they are almost exclusive, and the price may be determined at will.
As for the exact price of 3-amino-5-methoxypyridine at present, I have not been able to see the market situation firsthand, and there is no detailed data, so it is difficult to say clearly. However, according to the above reasons, if you want to know the price, you can personally go to the pharmaceutical and chemical industries and consult the merchants; or visit the people in the industry, who have been involved in this path for a long time, and will definitely be able to tell the recent price.