3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde hydrochloride (1:1)

This is 3-hydroxy-5- (hydroxymethyl) -2-methylpyridine-4-formaldehyde hydrochloride (1:1), which has unique chemical properties. In this compound, due to the presence of active groups such as hydroxyl, hydroxymethyl, and aldehyde groups, it has certain reactivity.
Hydroxy can participate in esterification reactions and react with acids to form ester compounds. Hydroxymethyl groups are also active and can be substituted and oxidized under specific conditions. The aldehyde group is active and can be oxidized to form carboxylic acids, and can also condensate with amino-containing compounds to form products such as Schiff base.
This compound has a certain alkalinity due to its pyridine ring, and can form a salt with acid, that is, form a 1:1 hydrochloride salt with hydrochloric acid. In the field of organic synthesis, these characteristics make it a key intermediate, which can be used to prepare a variety of complex compounds containing pyridine structures. In the reaction, it is necessary to pay attention to the difference in the reactivity of each group, and reasonably control the reaction conditions, such as temperature, pH, reaction time, etc., in order to achieve efficient synthesis of the target product.

3-Hydroxy-5- (hydroxymethyl) -2-methylpyridine-4-formaldehyde hydrochloride (1:1) This compound has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help create a variety of specific drugs. Due to its unique chemical structure, it can participate in a variety of chemical reactions, so it can be derived from compounds with specific biological activities, or as antibacterial drugs, or as antiviral remedies, or in the field of anti-tumor.
In the field of organic synthesis, it also plays an important role. Chemists can use it to construct complex organic molecular structures and expand the variety of organic compounds. Using them as starting materials and through exquisite reaction design, materials with special functions and properties can be prepared, which may emerge in the field of materials science, such as the research and development of new optical materials and electrical materials.
In addition, it is also an important research object in scientific research and exploration. Researchers can deepen their understanding of pyridine compounds through in-depth investigation of their reaction characteristics and physicochemical properties, and contribute to the theoretical development of related fields. Its performance under different reaction conditions can provide a rich practical basis for the improvement of chemical theory and promote the continuous development of chemistry.

The preparation of 3-hydroxy-5- (hydroxymethyl) -2-methylpyridine-4-formaldehyde hydrochloride (1:1) can be done according to the following ancient method.
First, appropriate starting materials are taken, and 2-methyl-3-hydroxypyridine is used as the base, and hydroxymethyl groups are introduced by hydroxymethylation reaction. This reaction requires a suitable solvent, such as dimethyl sulfoxide or N, N-dimethylformamide, in which an appropriate amount of formaldehyde and basic catalysts, such as potassium carbonate or sodium hydroxide, are added. The temperature is controlled in a certain range, about 50 to 70 degrees Celsius. When the reaction number is sufficient, an intermediate product containing 5- (hydroxymethyl) -2-methyl-3-hydroxypyridine can be obtained. Next, the intermediate product is formylated. Select a suitable formylating agent, such as a mixture of phosphorus oxychloride and N, N-dimethylformamide (Vilsmeier-Haack reagent). The above intermediate product is dissolved in an appropriate amount of anhydrous dichloromethane, at low temperature, such as 0 to 5 degrees Celsius, slowly add Vilsmeier-Haack reagent dropwise, and gradually heat up to room temperature. When the reaction number is continued, the formyl group is successfully introduced into the 4-position of the pyridine ring to obtain 3-hydroxy-5- (hydroxymethyl) -2-methylpyridine-4-formaldehyde.
Finally, the resulting 3-hydroxy-5- (hydroxymethyl) -2-methylpyridine-4-formaldehyde is dissolved in an appropriate amount of organic solvent, such as ethanol or ether, into the dried hydrogen chloride gas, moderate temperature control, about 0 to 10 degrees Celsius, until the reaction is complete, 3-hydroxy-5- (hydroxymethyl) -2-methylpyridine-4-formaldehyde hydrochloride (1:1) crystals are precipitated, and purified products can be obtained through filtration, washing, drying and other processes. Each step of the reaction requires attention to the control of reaction conditions, such as temperature, time, and reagent dosage, in order to achieve good yield and purity.

I don't know the market price of "3 - hydroxy - 5 - (hydroxymethyl) -2 - methylpyridine - 4 - carbalaldehyde hydrochloride (1:1) ". The price of this compound may vary due to changes in purity, origin, supply and demand. In the market, the price of fine chemicals often fluctuates due to a variety of reasons.
Some merchants may price by volume, and the unit price is low if the purchase quantity is large; or due to the difficulty of preparation, the price of raw materials, and the complexity of the process, the price is different. To know the exact price, consult chemical raw material suppliers, chemical trading platforms, such as Mobell, Gade Chemical Network, etc. There, you can get quotations from different manufacturers and refer to each other to know the approximate market price. And the chemical market is fickle, and prices often vary from time to time. Real-time inquiry is essential to obtain accurate prices.

3-Hydroxy-5- (hydroxymethyl) -2-methylpyridine-4-formaldehyde hydrochloride (1:1) is one of the chemical substances. Its storage conditions are crucial to the stability and quality of this substance.
The storage of this substance should first be placed in a cool place. If the cover temperature is too high, or it may cause chemical reactions to occur, causing structural changes and losing its inherent properties. A cool place can slow down the movement of its molecules and reduce its interaction with the surrounding environment to maintain the stability of its chemical properties.
Next, it should be in a dry place. Moisture can easily cause the substance to absorb moisture, or cause reactions such as hydrolysis, which will damage its purity and activity. Therefore, in a dry environment, it can avoid moisture intrusion and maintain the integrity of its chemical composition.
Furthermore, it must be sealed and stored. Sealing can isolate external air, water vapor and impurities from reacting with oxygen and carbon dioxide in the air. In this way, its quality can be protected for a long time for subsequent use.
In general, 3-hydroxy-5- (hydroxymethyl) -2-methylpyridine-4-formaldehyde hydrochloride (1:1) should be stored in a cool, dry and sealed environment. This is the key to protecting its properties and quality.