3-Hydroxy-4-methoxypyridine

3-Hydroxy-4-methoxypyridine is one of the organic compounds. It has a wide range of uses and plays an important role in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Through a series of chemical reactions, it can be cleverly converted into drug molecules with diverse structures. For example, the synthesis process of some drugs with specific biological activities relies on 3-hydroxy-4-methoxypyridine as the starting material. Due to its unique structure, it can endow the synthesized drugs with specific pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc. Through precise chemical modification, the interaction between drugs and biological targets can be adjusted, and the efficacy and safety of drugs can be improved.
In the field of materials science, 3-hydroxy-4-methoxypyridine also shows unique value. Because it contains specific functional groups, it can participate in the synthesis and modification of materials. For example, in the synthesis of functional polymer materials, it can be introduced into the polymer chain to endow the material with special properties such as optics and electricity. Alternatively, in the process of preparing materials with special adsorption or catalytic properties, it can be used as a modifier to change the surface properties of the material and enhance the adsorption or catalytic activity of the material to specific substances.
In addition, it is an extremely important building block in organic synthetic chemistry. With its reactivity of hydroxyl and methoxy groups, it can participate in various classical organic reactions, such as nucleophilic substitution, esterification, condensation, etc., to construct more complex organic molecular structures, providing organic synthesis chemists with rich synthesis strategies and possibilities, helping to create organic compounds with novel structures and unique functions.

3-Hydroxy-4-methoxypyridine, this is an organic compound. Its physical properties are quite important and are related to many chemical and industrial applications.
Looking at its properties, it is mostly a solid state under normal conditions, which is due to the intermolecular force. The presence of hydroxyl and methoxy groups in the molecule imparts a certain polarity to the molecule, so that hydrogen bonds can be formed between the molecules, which in turn prompts it to condense into a solid state.
When it comes to the melting point, it varies depending on the specific measurement conditions, and is roughly in a certain temperature range. The effect of hydrogen bonds and the regular arrangement of molecules have a great impact on the melting point. The tight and orderly arrangement and strong hydrogen bonds make the melting point relatively high.
The boiling point is also a key physical property. In view of the molecular polarity and hydrogen bonds, high energy is required to make the molecule overcome the interaction force and gasify, so the boiling point is relatively low.
In terms of solubility, because of its polarity, it has a certain solubility in polar solvents such as water. Hydroxyl and methoxy groups can form hydrogen bonds with water molecules to improve solubility. However, the non-polar part limits its infinite solubility in water, and the solubility is not very high. In organic solvents such as ethanol and acetone, the solubility is better. Due to the principle of similar miscibility, organic solvents are similar to the polarity of the compound, and intermolecular forces are conducive to dissolution.
The appearance color state is usually white to light yellow, and this color may be due to the absorption and reflection characteristics of the molecular structure to light. The density of
depends on the molecular mass and the degree of molecular packing. The molecular mass is large and closely arranged, resulting in a corresponding density, which is of great significance in chemical experiments and industrial production material measurement.
The physical properties of 3-hydroxy-4-methoxypyridine, such as properties, melting point, boiling point, solubility, appearance and density, are determined by the interaction of groups in the molecular structure, and are key factors in chemical research, synthesis and related application fields.

3-Hydroxy-4-methoxypyridine, which has unique chemical properties. It is a nitrogen-containing heterocyclic compound, and the hydroxyl and methoxy groups in its structure have a profound impact on its chemical behavior.
In terms of acidity and alkalinity, the nitrogen atom of the pyridine ring has lone pairs of electrons, which is weakly basic and can form salts with strong acids; while hydroxyl hydrogen has a certain acidity and can be dissociated under the action of strong bases, showing the characteristics of acids. This acidity and alkalinity change subtly in different chemical reactions and environments. In organic synthesis, the reaction process and product direction can be controlled by adjusting the pH of the reaction system.
Its nucleophilicity is also worthy of attention. Hydroxy oxygen atoms and pyridine cyclic nitrogen atoms are rich in electrons and have significant nucleophilicity. They can undergo nucleophilic substitution reactions with electrophilic reagents. For example, when encountering halogenated hydrocarbons, hydroxyl or nitrogen atoms will attack the carbon atoms of halogenated hydrocarbons, and the halogen atoms will leave to form replacement products. This reaction has a wide range of uses in the construction of complex organic molecular structures, and can introduce various functional groups.
In terms of thermal stability, 3-hydroxy-4-methoxypyridine is relatively stable, but when the temperature is too high, the chemical bonds in the molecule will vibrate and intensify, triggering decomposition or rearrangement reactions. Rearrangement may cause molecular structure changes and generate new isomers, affecting its chemical properties and uses.
In terms of solubility, due to the presence of hydroxyl and methoxy groups, these polar groups make it soluble in polar solvents such as water and alcohols, but the existence of pyridine rings limits its solubility. This solubility characteristic needs to be taken into account when separating, purifying and selecting the reaction solvent. Only by selecting the right solvent can the reaction proceed smoothly and achieve efficient separation of the target product.
In summary, the chemical properties of 3-hydroxy-4-methoxy pyridine are complex and delicate, and it has important application potential in many fields such as organic synthesis and pharmaceutical chemistry. Only by fully understanding and making rational use of its properties can a new realm of chemical research and application be opened.

The synthesis of 3-hydroxy-4-methoxypyridine has had many ingenious ideas since ancient times. One method is to use suitable pyridine derivatives as starting materials. If a pyridine with a specific substituent is selected, it should be modified with a specific reagent in a suitable reaction environment. This environment requires careful regulation of temperature, pressure and solvent type.
Common reaction systems use organic solvents as mediators, such as dichloromethane, N, N-dimethylformamide. Add reagents that can react at a specific position of the starting material to convert specific functional groups and approach the target product. < Br >
Another method can be used to construct pyridine rings from compounds containing hydroxyl groups and methoxy groups through ingenious reaction pathways. This pathway may involve multi-step reactions, such as condensation reactions, cyclization reactions, etc. Shilling compounds containing hydroxyl groups and methoxy groups, under the action of catalysts, condensate with specific nitrogen-containing compounds to form a preliminary structure. Then, by controlling the reaction conditions, they are cyclized to form a pyridine ring structure, and then 3-hydroxy-4-methoxy pyridine is obtained.
In addition, natural products are also used as the starting point and chemically modified to reach them. In natural products, or those with similar structures, after extraction and separation, the structure is modified by chemical means, and the required hydroxyl and methoxy groups are introduced to obtain the final target product. Each of these methods has its own length, and it needs to be carefully selected according to the actual availability of raw materials, the controllability of reaction conditions and many other factors.

I look at the price range of 3-hydroxy-4-methoxypyridine in the market. The price of this chemical substance varies due to many reasons, and it is not easy to determine the exact number.
First, its purity is related to the large obstacle. If the purity is high, it is close to analytical purity or higher, and it is suitable for fine research experiments, its price is high. For industrial use, the purity is slightly lower, and the price is slightly reduced.
Furthermore, the amount purchased also affects the price. If you buy in bulk, merchants often give it at a preferential price to promote transactions, with small profits but quick turnover. If you buy only a small amount, it is a laboratory trial or the like, and the price per unit is higher.
In addition, the supply and demand situation of the market also affects its price. If there are many applicants, but there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop.
According to past market conditions, those with high purity can cost tens of yuan per gram; if you buy industrial grade in bulk, it can cost hundreds of yuan per kilogram. However, these are all approximate numbers, and market conditions change frequently. The actual price should be consulted with chemical material suppliers or chemical trading platforms to get a near-real price.