3-Hydroxy-2-pyridinecarboxylic acid methyl ester

3-Hydroxy-2-methylpyridinecarboxylate, this is a kind of organic compound. Its properties have specific physical and chemical characteristics.
Looking at its physical properties, under room temperature, it is either a solid state or a liquid state, depending on the intermolecular force and structure. Its melting and boiling point is determined by the interaction between molecules, and hydrogen bonds, van der Waals forces, etc. are affected. If there are many hydrogen bonds between molecules, the melting and boiling point may be higher.
In terms of its chemical properties, hydroxyl groups are active and can participate in many reactions. If reacted with acid anhydride and acid chloride, esters can be formed; in case of oxidants, hydroxyl groups may be oxidized. Pyridine rings are aromatic and can undergo electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. Pyridine nitrogen atoms can provide electron pairs to coordinate with metal ions to form complexes.
And methyl ester groups are also reactive, and can be hydrolyzed into carboxylic acids and methanol under the catalysis of acids or bases. Base-catalyzed hydrolysis is easier because it can react with hydrolyzed acids to shift the equilibrium to the right. In addition, it can also undergo transesterification reactions with alcohols to obtain new esters.
Methyl 3-hydroxy-2-pyridinecarboxylate is widely used in the field of organic synthesis. It can be used as an intermediate to construct complex organic molecules through various reactions. It is often used in the synthesis of fine chemicals such as medicine and pesticides.

Methyl 3-hydroxy-2-pyridinecarboxylate is an organic compound. It has a wide range of common uses and can be used as a key intermediate in the field of organic synthesis. Because its molecular structure contains both hydroxyl and ester groups, this difunctional group endows it with unique reactivity. With the active properties of hydroxyl groups, it can participate in many esterification, etherification and other reactions; and ester groups can also undergo hydrolysis, alcoholysis and other transformations to build more complex organic molecular structures. In the field of pharmaceutical chemistry, it often lays the foundation for the design and synthesis of lead compounds.
From the perspective of materials science, it may be used to prepare polymer materials with specific properties. Because it can participate in the polymerization reaction as a monomer, the resulting polymer material has unique physical and chemical properties, such as improving the solubility and thermal stability of the material.
Furthermore, it can also be seen in the fine chemical industry. Or used to synthesize special fragrances, additives and other fine chemicals to add unique properties and characteristics to the product. In short, methyl 3-hydroxy-2-pyridinecarboxylate plays an indispensable role in many fields such as organic synthesis, drug development, materials science and fine chemistry, and is a class of extremely important compounds in the field of organic chemistry.

The synthesis method of methyl 3-hydroxy-2-pyridinecarboxylate has been recorded in many books in the past, but its methods are different and each has its own strengths.
First, using methyl 2-pyridinecarboxylate as the starting material, through halogenation reaction, halogen atoms are introduced, and then hydrolysis and oxidation series of steps, the target product can be obtained. The halogenation method is quite critical in this way. The choice of halogenating agent and the control of reaction conditions are all related to the yield and purity of the product. If the appropriate halogenating agent is selected, the reaction at a specific temperature and duration can obtain a highly active halogenated intermediate. The subsequent hydrolysis and oxidation also need to be precisely regulated to achieve the best effect.
Second, starting from 3-hydroxypyridine, carboxyl derivatives are introduced through acylation reaction, and then esterified to obtain 3-hydroxy- 2-pyridinecarboxylate methyl ester. During acylation, the properties of acylation reagents and the acid and base of the reaction environment all affect the acylation efficiency. In the esterification step, the type and amount of catalyst, and the anhydrous degree of the reaction system also have important effects on the formation of the product.
Third, with suitable pyridine derivatives as substrates, a metal-catalyzed cross-coupling reaction is used to construct the skeleton of the target molecule, and then the functional group is converted to obtain the desired product. Factors such as the activity and selectivity of metal catalysts, the structure and properties of ligands, and the polarity of the reaction solvent are crucial in this method. Reasonable blending of these factors can improve the reaction activity and selectivity and optimize the yield of the product.
There are many methods for synthesizing methyl 3-hydroxy-2-pyridinecarboxylate, and each method requires careful consideration of the reaction conditions, raw material characteristics and reagent properties to obtain satisfactory results.

I am not aware of the market price range of "3 - Hydroxy - 2 - pyridinecarboxylic acid methyl ester". This compound may be used in the fields of chemical raw materials and pharmaceutical intermediates. To know its price, it is advisable to consult chemical product suppliers, distributors, or check chemical product trading platforms. However, the price of chemical products often changes due to quality, purity, purchase quantity, and market supply and demand.
If the purchase volume is huge, the bargaining space may be large, and the price may be more favorable. And different origins and brands of products have different prices. In addition, market conditions are fickle, and price fluctuations are also common. Therefore, seeking a definite price, when the recent market conditions are carefully investigated, and multiple parties are investigated and compared, a more accurate price range can be obtained.

Methyl 3-hydroxy-2-pyridinecarboxylate, this is an organic compound. Its storage conditions are crucial and related to the quality and stability of the compound.
When storing, it should be in a cool place away from light. Direct sunlight and excessive temperature can cause chemical reactions to occur, causing damage to its structure and changing its properties. If exposed to strong light and high temperature, it may cause changes such as breaking and rearrangement of chemical bonds in the molecule, resulting in reduced purity and loss of activity.
Furthermore, it needs to be placed in a dry place. Water vapor in the air can interact with the compound. Some organic compounds are prone to moisture absorption, and after moisture absorption, they may cause deliquescence or cause hydrolysis. If methyl 3-hydroxy-2-pyridinecarboxylate is damp, it may gradually hydrolyze to form corresponding acids and alcohols, which affects its quality and use.
And should be kept away from fire sources and strong oxidants. This compound may be flammable, and it is easy to catch fire and burn in case of fire sources, endangering safety. Strong oxidants can oxidize with some of the groups in it, causing drastic changes in its chemical properties and losing its original characteristics and functions.
Storage containers should not be ignored, and well-sealed containers should be used. Sealing can effectively prevent the intrusion of impurities such as air and water vapor, and maintain the stability of its chemical environment. Glass containers or corrosion-resistant plastic containers are more suitable, depending on the chemical properties of the compound. < Br >
Proper storage of methyl 3-hydroxy-2-pyridinecarboxylate in a cool, dry place, away from sources of ignition and strong oxidizing agents, and in a well-sealed container to maintain its stability for subsequent use.