3-Hydroxy-2-iodopyridine

3-Hydroxy-2-iodopyridine is an organic compound with a wide range of main uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique molecular structure, the hydroxyl group and the iodine atom coexist on the pyridine ring. This structure endows it with special reactivity and can derive a variety of organic compounds through many chemical reactions, such as nucleophilic substitution and coupling reactions.
In the field of pharmaceutical chemistry, it also shows potential application value. Researchers have found that compounds containing pyridine structures are often biologically active, and 3-Hydroxy-2-iodopyridine, as a pyridine derivative, may become an important starting material for the development of new drugs. By modifying and optimizing its structure, it is expected to create drug molecules with specific pharmacological activities, such as drugs with antibacterial, anti-inflammatory, anti-tumor and other effects.
In the field of materials science, it may participate in the preparation of functional materials. With its unique chemical structure, specific properties may be introduced in the material synthesis process, such as improving the electrical and optical properties of materials, etc., which in turn provides a new way for the research and development of new materials.
In addition, in the field of pesticide chemistry, it also has potential uses. It can be used as an intermediate for the synthesis of new pesticides, and can design and synthesize highly efficient, low-toxic and environmentally friendly pesticide varieties, which can help the sustainable development of agriculture.
In summary, 3-Hydroxy-2-iodopyridine has important uses in many fields such as organic synthesis, medicinal chemistry, materials science and pesticide chemistry due to its special structure, providing an important material basis for research and development in various fields.

The synthesis method of 3-hydroxy-2-iodopyridine, as described in the past books, has the following numbers.
First, it can be prepared by the sequential reaction of halogenation and hydroxylation of pyridine compounds. First, the pyridine is introduced into the iodine atom at the 2-position of the pyridine ring under specific reaction conditions with a suitable halogenation reagent, such as the halogenating agent of iodine. This halogenation reaction requires temperature control, selection of suitable solvents and catalysts. After the halogenation is completed, the hydroxylation reaction is carried out, often with reagents such as alkali metal hydroxides, under appropriate temperature, time and solvent environment, to promote the formation of hydroxyl groups at the 3-position, and then obtain 3-hydroxy-2-iodopyridine. < Br >
Second, pyridine derivatives containing hydroxyl groups and halogen atoms are used as raw materials and obtained by functional group conversion. Such as some 3-hydroxypyridine derivatives, the hydroxyl group is first protected to prevent it from being disturbed in subsequent reactions. Then, iodine atoms are introduced at the 2-position through halogenation. After the halogenation is completed, the protective group of the hydroxyl group is removed, and the target product can also be obtained. This path requires fine selection of protective groups and deprotection conditions to ensure the high efficiency of the reaction and the purity of the product.
Third, the coupling reaction catalyzed by transition metals. Using 3-hydroxypyridine derivatives and iodine substitutes as substrates, under the catalysis of transition metal catalysts such as palladium and copper, in the presence of ligand synergy and specific bases, a coupling reaction occurs to introduce iodine atoms at the 2-position. This method requires strict reaction conditions. The choice of catalyst, ligand, and the type and dosage of base are all related to the success or failure of the reaction and the yield.
The above synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs, raw material availability and feasibility of reaction conditions.

3-Hydroxy-2-iodopyridine is one of the organic compounds. Its physical properties are quite unique, let me tell them one by one.
Looking at its appearance, it often takes the form of a white-like to light yellow crystalline powder, which is easy to observe and handle. As for its melting point, it is in a specific temperature range, but it fluctuates slightly due to the different preparation methods and purity. It is probably around [X] ° C. This melting point characteristic plays a key role in the identification and purification of this substance.
Solubility is also an important physical property. In organic solvents, its solubility varies. In common organic solvents such as dichloromethane, N, N-dimethylformamide, etc., it exhibits a certain solubility and can form a uniform solution, which is conducive to its dispersion and participation in the reaction system of organic synthesis. In water, its solubility is relatively limited, only slightly soluble, which is also related to the polar structure of the molecule.
Its density is also a physical constant. Although the exact value needs to be accurately measured, the approximate range is established. It is indispensable for quantitative access and reaction design due to the space and quality relationship it occupies in actual operation.
Furthermore, the stability of this substance is also a consideration of physical properties. In a dry environment at room temperature and pressure, it can still maintain a relatively stable state. When exposed to high temperature, strong light or a specific chemical environment, chemical changes may occur, causing changes in its structure and properties.
In summary, the physical properties of 3-hydroxy-2-iodopyridine, such as appearance, melting point, solubility, density and stability, are of great significance in many fields such as organic synthesis and drug development, providing necessary basic information for related research and applications.

3-Hydroxy-2-iodopyridine, this is an organic compound. Its chemical properties are unique and interesting.
First talk about the properties of its hydroxyl groups, which are active functional groups and have significant nucleophilic properties. In many chemical reactions, hydroxyl groups can be used as nucleophilic reagents to react with electrophilic reagents, such as nucleophilic substitution reactions. Under suitable conditions, the oxygen atoms in the hydroxyl group will attack the electron-deficient center of the electrophilic reagent by virtue of their lone pair electrons, and then form new chemical bonds.
Furthermore, the compound contains iodine atoms, which have a large radius and relatively moderate electronegativity. This makes iodine atoms exhibit certain unique properties in molecules. Iodine atoms can participate in some special reactions, such as the reverse process of iodine substitution reaction. Under specific reduction conditions, iodine atoms may be reduced away. Moreover, due to the existence of iodine atoms, the distribution of the electron cloud of the molecule will be affected, and the reactivity of the pyridine ring and hydroxyl group connected to it will be indirectly affected.
The pyridine ring is also a key structural part of the compound. The pyridine ring is aromatic, the electron cloud is uniformly distributed, and its properties are relatively stable. However, the lone pair electrons on its nitrogen atom make the pyridine ring have a certain alkalinity and can react with acids to form pyridine salts. At the same time, there are differences in the electron cloud density at different positions on the pyridine ring. The substitution of hydroxyl and iodine atoms in 3-hydroxy-2-iodine pyridine further changes the electron cloud distribution on the pyridine ring, resulting in changes in the reactivity at different positions of the pyridine ring, thereby affecting the selectivity of the whole molecule in reactions such as electrophilic substitution or nucleophilic substitution.
Overall, 3-hydroxy-2-iodine pyridine has diverse and unique chemical properties due to the synergistic effect of hydroxyl groups, iodine atoms and pyridine rings, which has potential application value in organic synthesis and other fields.

3 - Hydroxy - 2 - iodopyridine is an organic compound, and it is difficult to make a definite conclusion in the market price range. Its price is influenced by multiple factors.
The first to bear the brunt is the difficulty of the preparation process. If its synthesis requires cumbersome reactions in multiple steps, strict reaction conditions are required, such as specific catalysts, precise temperature and pressure control, and raw materials are rare or expensive, so the production cost rises and the price rises.
Furthermore, the market supply and demand relationship is also key. If this compound is in high demand in the fields of medicine, materials science, etc., but the supply is limited, according to market rules, the price will rise; on the contrary, if the demand is weak, and there are many manufacturers and sufficient supply, the price may fall.
In addition, the manufacturer's brand and product purity also have an impact. Well-known manufacturers, due to their emphasis on quality control, have high product purity and few impurities, and their product prices may be higher than those of ordinary manufacturers.
From the perspective of "Tiangong Kaiwu", everything has its price, but this price is not static, but is influenced by various factors such as process, supply and demand, and quality. To know the exact price of 3 - Hydroxy - 2 - iodopyridine, it is recommended to consult chemical product suppliers, browse chemical product trading platforms, or communicate with industry insiders at relevant industry conferences and forums to obtain a relatively accurate price range.