3-Hydroxy-2-bromo-6-(trifluoromethyl)pyridine

3-Hydroxy-2-bromo-6- (trifluoromethyl) pyridine, an organic compound, has unique chemical properties and is of great significance in the field of organic synthesis.
Its chemical properties first promote the activity of halogen atoms. The molecule contains bromine atoms. Bromine is a halogen element with high electronegativity, causing C-Br bonds to be polar. This polarity makes bromine atoms vulnerable to nucleophilic reagents and nucleophilic substitution reactions occur. For example, under suitable conditions, it can react with nucleophilic reagents such as sodium alcohol and amines, and the bromine atoms are replaced by corresponding groups to generate new nitrogen-containing or oxygen-containing derivatives, which lay the foundation for the construction of complex organic molecules.
Furthermore, the properties of hydroxyl groups cannot be underestimated. Hydroxyl groups are active functional groups and can participate in many reactions. Because oxygen atoms have lone pairs of electrons and are basic, they can neutralize with acids to form corresponding salts. At the same time, hydroxyl groups can undergo esterification reactions, and dehydrate with carboxylic acids or acid chlorides under the action of catalysts to form ester compounds. This reaction is widely used in organic synthesis, used in the preparation of fragrances, pharmaceutical intermediates, etc.
In addition, the presence of trifluoromethyl groups endows the compound with special properties. Trifluoromethyl groups have strong electron-absorbing properties and can significantly affect the electron cloud density distribution of pyridine rings. Reduce the electron cloud density of pyridine rings, increase the difficulty of electrophilic substitution reactions, and change the regioselectivity. In the electrophilic substitution reaction, the substituents tend to enter the relatively high electron cloud density of the pyridine ring. At the same time, the strong electron absorption of trifluoromethyl enhances the lipid solubility of molecules, which affects the physical properties of compounds such as melting point, boiling point, solubility, etc. In drug development, drug absorption and distribution can be improved.
In summary, 3-hydroxy-2-bromo-6 - (trifluoromethyl) pyridine has broad application prospects in the fields of organic synthesis and medicinal chemistry due to its functional groups and special structures.

The synthesis of 3-hydroxy-2-bromo-6- (trifluoromethyl) pyridine is an important topic in organic synthetic chemistry. This compound has potential application value in the fields of medicinal chemistry and materials science. Its synthesis methods have been investigated by predecessors, and the synthesis methods are different.
One method is to use 6- (trifluoromethyl) pyridine-2-ol as the starting material. First, it is combined with appropriate brominating reagents, such as hydrogen bromide or N-bromosuccinimide (NBS), under suitable reaction conditions. When using hydrogen bromide, the hydroxy group can be refluxed in a solvent to be replaced by a bromine atom to obtain 2-bromo-6- (trifluoromethyl) pyridine. This step requires attention to the control of reaction temperature and time to prevent over-bromination or other side reactions. Subsequently, after appropriate oxidation steps, hydroxyl groups can be introduced at the third position. For example, with suitable oxidizing agents, such as potassium permanganate or m-chloroperoxybenzoic acid (m-CPBA), etc., under appropriate solvent and temperature conditions, the synthesis of 3-hydroxy-2-bromo-6- (trifluoromethyl) pyridine can be achieved. < Br >
There is another method, using the pyridine derivative containing trifluoromethyl as the starting material, first functionalizing the other positions of the pyridine ring, and then gradually constructing the structure of the target molecule through a series of reactions such as halogenation and hydroxylation. However, no matter what method, the selectivity of the reaction, the yield and the difficulty of post-treatment must be considered. During the synthesis process, the intermediates of each step of the reaction must be accurately characterized and purified to ensure the purity and quality of the final product.

3-Hydroxy-2-bromo-6- (trifluoromethyl) pyridine is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. This compound can be synthesized through a specific chemical synthesis path to prepare biologically active drug molecules. Because of the hydroxyl groups, bromine atoms and trifluoromethyl groups contained in its structure, it can endow the prepared drug with unique pharmacological properties, such as enhancing the binding force between the drug and the target and improving the metabolic stability of the drug.
In the field of pesticide chemistry, 3-hydroxy-2-bromo-6- (trifluoromethyl) pyridine also plays an important role. It can be converted into pesticide components with high insecticidal, bactericidal or herbicidal activities by chemical modification. Due to its unique chemical structure, it can produce significant biological activity against specific pests, bacteria or weeds, and may be more selective and environmentally friendly than traditional pesticides.
In addition, in the field of materials science, the compound also shows potential application value. Due to its special chemical structure and electronic properties, it can be used to prepare functional materials with specific optical, electrical or thermal properties. For example, it can be used as a basic structural unit for constructing Light Organic Emitting Diode (OLED) materials, endowing the materials with unique luminescent properties, and then applied to display technology and other fields.
In summary, 3-hydroxy-2-bromo-6- (trifluoromethyl) pyridine has important uses in many fields such as medicine, pesticides and materials science, providing key chemical raw materials and research bases for research and development in related fields.

3-Hydroxy-2-bromo-6- (trifluoromethyl) pyridine is a commonly used intermediate in organic synthesis. If you want to store it properly, you need to pay attention to various things.
First, this substance is more sensitive to moisture. Moisture invasion, or cause its hydrolysis, which changes the chemical structure and damages the quality and activity. Therefore, be sure to ensure that the environment is dry when storing. It can be placed in a dryer or added to a desiccant in a storage container to prevent moisture from invading.
Second, light is also the key. This pyridine compound is irradiated or caused by luminescent chemical reactions to cause structural changes. Therefore, it should be hidden in a dark container such as a brown bottle, or placed in a dark place to protect it from light.
Third, temperature control is also important. Under high temperature, molecular motion intensifies, or causes reactions such as decomposition and polymerization. Usually it should be stored in a cool place, generally 2-8 ° C. If there is no low temperature condition, room temperature (15-30 ° C) and a heat-proof place can also be used.
Fourth, the material of the storage container also needs to be considered. Containers with stable chemical properties and no reaction should be selected. Glass containers are often preferred because of their good chemical stability in most cases. However, it should be noted that if this substance is sensitive to alkali, glass or react with it in a strong alkali environment, other materials such as plastic containers may need to be considered at this time.
Fifth, also pay attention to isolated storage. Do not co-store with strong oxidants, strong reducing agents, acids, bases, etc., to prevent dangerous chemical reactions and endanger safety.
In short, when storing 3-hydroxy-2-bromo-6 - (trifluoromethyl) pyridine, pay attention to drying, protection from light, temperature control, selection of suitable containers and isolated storage, so as to ensure its quality and stability.

I don't know the exact market price of 3-hydroxy-2-bromo-6- (trifluoromethyl) pyridine. The price of this compound often varies due to many factors.
First, the yield is the key factor. If the production scale of this product is large and abundant, the price may stabilize and be low according to the reason of supply and demand. On the contrary, if the output is small, the supply will exceed the demand, and the price may rise.
Second, purity also affects the price. High purity 3-hydroxy-2-bromo-6- (trifluoromethyl) pyridine is difficult to prepare and the process is complicated, so the price must be higher than that of low purity.
Third, the market demand situation determines the price. If there is a strong demand for this product in many industries, such as medicine, chemical industry and other fields, the price may also rise.
Fourth, the cost of raw materials and the preparation process are also related to the price. If the raw materials required for preparation are rare and expensive, or the preparation process is complicated, and manpower, material and financial resources are consumed, the price of the product will be high.
Due to the rapidly changing market and different pricing strategies of various suppliers, if you want to know its accurate market price, you should consult chemical product suppliers, traders, or consult professional chemical product price information platforms to get the latest and accurate price information.