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What are the physical properties of 3-Hydroxy-2-aminopyridine?
3-Hydroxy-2-aminopyridine, this is an organic compound. Its physical properties are unique and of great significance.
When it comes to appearance, it is usually a white to light yellow crystalline powder, like fine snow, with a pure appearance. Under normal temperature and pressure, it is as stable as a rock, and its chemical properties are relatively stable. In case of special conditions, it will also show a lively state.
Its melting point is quite high, about 147-151 ° C. Just like in a high temperature furnace, it has been tempered for thousands of times to obtain this stable state. Such a high melting point makes it able to maintain a solid state in many common environments and is not easy to melt.
Solubility is also an important property. 3-Hydroxy-2-aminopyridine is slightly soluble in water, just like a shy guest, willing to stay in water for a while and dissolve a little. However, it is easily soluble in organic solvents such as methanol and ethanol, just like a fish entering a river, swimming freely. This difference in solubility provides a different path for it in various chemical reactions and separation and purification processes.
In addition, 3-hydroxy-2-aminopyridine contains hydroxyl and amino groups in its molecular structure, which give it unique chemical activity and also have a subtle impact on its physical properties. The presence of hydroxyl groups allows hydrogen bonds to be formed between molecules, which in turn affects the melting point and solubility. The properties of amino groups also add different activities and interactions to molecules. In conclusion, the physical properties of 3-hydroxy-2-aminopyridine, such as its appearance, melting point, solubility, etc., are determined by its molecular structure, and play a key role in many applications in the field of chemistry, laying a solid foundation for subsequent research and practice.
What are the chemical properties of 3-Hydroxy-2-aminopyridine?
3-Hydroxy-2-aminopyridine, this substance is weakly basic because its amino group can bind protons. It also has a certain acidity, and hydroxy hydrogen can be dissociated. In different acid and base environments, its existence forms are different.
It is nucleophilic, and the lone pair electrons of amino and hydroxyl groups can attack electrophilic reagents. In electrophilic substitution reactions, amino and hydroxyl groups are ortho-para-sites, which increase the density of electron clouds in the benzene ring and make it easier to react with electrophilic reagents, and the reactions mostly occur in the ortho-para-sites of amino or hydroxyl groups.
This compound also has coordination ability. With amino and hydroxyl groups, it can form complexes with metal ions, and has a wide range of uses in the fields of materials science and catalysis. The hydroxyl group can participate in the esterification reaction and form esters with acids under the action of catalysts; the amino group can undergo acylation reaction and react with acyl halide or acid anhydride to obtain amide compounds.
In organic synthesis, 3-hydroxy-2-aminopyridine is an important intermediate. With its diverse reactivity, it can construct complex organic molecular structures. In the field of medicinal chemistry, it is often the starting material for the development of new drugs. Due to its unique chemical properties, it may endow drugs with specific biological activities and pharmacological functions.
What are the main uses of 3-Hydroxy-2-aminopyridine?
3-Hydroxy-2-aminopyridine, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to its unique chemical structure, it has the potential to interact with specific targets in organisms. For example, it can be modified by its structure to design and synthesize compounds with specific pharmacological activities, or used to develop antibacterial drugs to interfere with the metabolic process of bacteria; or used to create anti-cancer drugs to affect the proliferation and apoptosis of tumor cells.
In the field of materials science, 3-hydroxy-2-aminopyridine also has extraordinary performance. Due to its ability to form stable complexes with metal ions, it has unique advantages in the preparation of functional materials. It can be used to prepare luminescent materials and is used in display technology and other fields. Due to its special structure after combining with metal ions, it can produce unique optical properties and emit light of specific wavelengths, which contributes to the development of display technology.
In the field of organic synthesis chemistry, it is an important synthetic building block and participates in the construction of many complex organic compounds. Because its molecules contain both hydroxyl and amino groups, it can be connected with other organic molecules through various chemical reactions, such as nucleophilic substitution and condensation reactions, to construct organic compounds with diverse structures, greatly enriching the pathways and product types of organic synthesis.
Overall, 3-hydroxy-2-aminopyridine has shown important application value in many fields such as medicine, materials, and organic synthesis due to its unique chemical structure, which is of great significance for promoting the development of related fields.
What are 3-Hydroxy-2-aminopyridine synthesis methods?
3-Hydroxy-2-aminopyridine is also an organic compound. The synthesis method has been different throughout the ages, and let me know one by one.
First, pyridine is used as the starting material. Before the specific position of the pyridine ring, the hydroxyl group is introduced through a clever substitution reaction. The introduction of this hydroxyl group requires precise control of the reaction conditions, such as temperature, solvent, catalyst, etc. When the hydroxyl group is in place, the amino group is introduced. The aminolysis reaction can be used to replace the suitable group on the pyridine ring to obtain 3-hydroxy-2-aminopyridine. However, in this process, the control of the reaction conditions is very important. If there is a slight difference, the product will be impure or the yield will not be high.
Second, pyridine derivatives containing specific substituents can also be used as raw materials. If the raw material already has some of the required substituents, it only needs to undergo appropriate conversion reactions, such as oxidation, reduction, substitution, etc., to gradually build the structure of the target molecule. For example, the raw material pyridine derivative has convertible groups similar to hydroxyl or amino groups, which can be converted into the required hydroxyl and amino groups through appropriate reactions, and then 3-hydroxy-2-aminopyridine can be synthesized. The key to this method lies in the precise selection of the raw material structure and the skilled use of each step of the conversion reaction.
Third, there are still those who take the heterocyclic synthesis method as the path. Through multi-step reactions, pyridine rings are gradually constructed from simple organic compounds, and hydroxyl and amino groups are introduced at appropriate check points on the rings. This approach requires careful design of reaction routes, and each step is closely connected to the reaction, and attention should be paid to the selectivity and yield of the reaction. For example, some small molecules containing nitrogen and oxygen are used as starting materials, through condensation, cyclization and other reactions to form pyridine rings, and then the rings are modified with hydroxyl and amino groups.
All this synthesis method has advantages and disadvantages, and needs to be carefully selected according to actual needs, such as the availability of raw materials, cost considerations, and product purity requirements.
3-Hydroxy-2-aminopyridine What are the precautions in storage and transportation?
3-Hydroxy-2-aminopyridine is an organic compound. When storing and transporting, pay attention to the following things:
First, the storage environment is very important. This compound should be stored in a cool, dry and well-ventilated place. Because it may be quite sensitive to humidity and temperature, high temperature and humid environment, or cause its properties to change, and even cause chemical reactions. If the humidity is too high, 3-hydroxy-2-aminopyridine may absorb moisture, affecting its purity and stability; if the temperature is too high, or accelerate its decomposition process. Therefore, it should be kept away from heat and fire sources to prevent accidents.
Second, the packaging must be tight. Appropriate packaging materials need to be used to ensure that they are well sealed to avoid contact with air, moisture, etc. Common packaging is in glass bottles, plastic bottles or sealed drums lined with plastic bags. Packaging materials should have corrosion resistance and do not react with 3-hydroxy-2-aminopyridine to ensure that their quality is not damaged.
Third, when transporting, relevant regulations and standards should be followed. This compound may belong to the category of hazardous chemicals. Before transporting, its dangerous characteristics, such as whether it is flammable, explosive, toxic, etc., must be clarified, and classified and marked according to regulations. During transportation, it should be properly fixed to prevent collision, vibration and dumping, so as to avoid leakage due to package damage.
Fourth, isolation from other substances cannot be ignored. During storage and transportation, do not mix or mix with strong oxidants, strong acids, strong bases and other substances. Due to the chemical structure of 3-hydroxy-2-aminopyridine, it may react violently with the above substances, causing safety accidents.
In short, the storage and transportation of 3-hydroxy-2-aminopyridine requires great attention to the environment, packaging, regulatory compliance and material isolation, so as to ensure its quality and transportation safety.