3-fluoropyridine

3-Fluoropyridine, as well as organic compounds, has a wide range of uses.
In the field of medicinal chemistry, this is a key intermediate. With its unique structure, a variety of bioactive molecules can be constructed. Such as the synthesis of many antibacterial, anti-inflammatory and anti-tumor drugs, 3-fluoropyridine plays an important role. Taking a new type of antibacterial drug as an example, its core structure is derived from the derivatization of 3-fluoropyridine, which can precisely act on specific bacterial targets, block its key metabolic pathways, and achieve antibacterial effects.
In pesticide chemistry, 3-fluoropyridine is also indispensable. High-efficiency insecticides and fungicides can be prepared. Due to the introduction of fluorine atoms, it enhances the binding force between molecules and targets, enhances drug efficacy, and reduces environmental impact. For example, a new type of insecticide, based on 3-fluoropyridine, has a specific interference effect on the nerve conduction of pests, effectively kills pests, and is relatively friendly to beneficial insects and the environment.
Furthermore, in the field of materials science, 3-fluoropyridine can be used to synthesize functional materials. The polymer materials involved in the synthesis have special electrical and optical properties. For example, such polymers can be used to prepare organic Light Emitting Diodes (OLEDs), which can improve the luminous efficiency and stability due to their structural properties, contributing to the development of display technology.
In conclusion, 3-fluoropyridine has important uses in many fields such as medicine, pesticides, and materials due to its unique chemical properties, promoting technological innovation and progress in various fields.

3-Fluoropyridine is one of the organic compounds with unique physical properties. It is a colorless to light yellow liquid at room temperature and pressure. It is clear and transparent when viewed, and has a special smell. Although this smell is not pungent or intolerable, it is also distinct, and the smell can sense the unique smell of its chemical substances.
When it comes to the boiling point, it is about 147-149 ° C. The boiling point is the temperature limit for a substance to change from liquid to gaseous. 3-Fluoropyridine can be converted from liquid to gaseous in this temperature range. Its melting point is about -45 ° C. When the temperature drops below the melting point, the substance solidifies from liquid to solid. < Br >
The density of 3-fluoropyridine is about 1.159 g/mL (25 ℃). The density is also the mass of the substance per unit volume. This value shows that under the same volume, 3-fluoropyridine is heavier than water, because its density is greater than 1 g/mL of water.
In terms of solubility, 3-fluoropyridine can be miscible with a variety of organic solvents, such as ethanol, ether, acetone, etc. However, its solubility in water is limited and only slightly soluble. This property is due to the difference between its molecular structure and the forces between water molecules. The molecular structure of organic solvents is more compatible with 3-fluoropyridine, so it can be miscible; while the molecular structure of water is different, so it does not dissolve well in water.
In addition, 3-fluoropyridine has a certain degree of volatility. Volatile, the ability of substances to escape from the liquid surface into the gas phase. Because of its volatility, in an open environment, it will gradually be released into the air. This property is also related to the boiling point. Substances with lower boiling points are usually more volatile. The volatility of 3-fluoropyridine should be paid attention to during operation and storage to prevent its escape from causing loss or safety hazards.

3-Fluoropyridine is an organic compound and is widely used in many fields such as medicine, pesticides and materials science. Its synthesis method has been studied by many predecessors, and now it is Jun Chen's.
First, halogen exchange method. 3-chloropyridine is used as a raw material, co-heated with a fluorinating agent, and 3-fluoropyridine is obtained by halogen exchange reaction. This fluorinating agent is commonly used, such as potassium fluoride. In an appropriate solvent, such as dimethyl sulfoxide, heat and stir, and the reaction product can be obtained. This method is relatively simple, but high temperature is required, and the selectivity of halogen exchange may be insufficient, and side reactions may also occur.
Second, diazotization method. First, 3-aminopyridine is reacted with sodium nitrite and acid to form a diazonium salt. Next, it is reacted with fluoroboronic acid or its salts to obtain 3-fluoropyridine. In this process, the diazotization reaction needs to be controlled at low temperature, and the stability of the diazonium salt is not good, so the operation should be cautious. However, its advantage is that fluorine atoms can be introduced accurately, and the product purity is high.
Third, metal catalysis. Transition metals, such as palladium and copper, are used as catalysts to react fluorinated reagents with pyridine derivatives. For example, pyridyl boric acid derivatives and fluoroaromatics are coupled to synthesize 3-fluoropyridine under metal catalysis. This method has relatively mild conditions and good selectivity. However, the cost of the catalyst may be higher, and the recovery and repurposing of the catalyst need to be considered.
Fourth, electrochemical synthesis method. In an electrochemical system, fluorine atoms are introduced through electrode reaction with pyridine-containing substrates to generate 3-fluoropyridine. This method is green and environmentally friendly, does not require the use of a large number of chemical reagents, but requires high equipment requirements, and the reaction mechanism needs to be further explored to optimize the reaction conditions and improve the yield.
All this synthesis method has advantages and disadvantages. In practical application, when considering many factors such as raw material availability, cost, product purity and scale, the choice should be weighed.

The price range of 3-fluoropyridine in the market is difficult to determine. Its price often changes for many reasons, and the behavior is also changing at any time.
Looking at the past, the price of chemicals has always been determined by supply and demand, production method, quality and market conditions. If the demand for this product is very high, but the supply is limited, the price will tend to be higher; conversely, if the supply exceeds the demand, the price may fall.
The production method is also the main reason. If the preparation method is simple and low cost, the price may be close to the people; if the process is complicated, special materials are required or the conditions are strict, the cost will increase, and the price will follow. The quality also affects its price. High purity, high quality, the price is often higher.
The fluctuation of market conditions is also related to prices. Economic prosperity, policy changes, and competition can all cause prices to rise and fall.
If you want to know the price of 3-fluoropyridine now, you should consult chemical raw material suppliers, traders, or explore chemical product trading platforms and market survey reports to obtain a more accurate price range at the moment.

3-Fluoropyridine is also an organic compound. During storage and transportation, many matters cannot be ignored.
First word storage. This substance should be placed in a cool and ventilated warehouse. Because it is cool, it can prevent its heat-induced reaction from intensifying, and ventilation can dissipate harmful gases that may accumulate, ensuring environmental safety. The temperature of the warehouse should be controlled within a certain range. If it is too high, it will easily cause its volatilization to accelerate, or cause other unstable changes. And it should be kept away from fire and heat sources. Open flames and hot topics can trigger hazards, such as combustion and explosion. It must be stored separately from oxidants, acids, bases, etc. These are easy to react chemically with 3-fluoropyridine, and mixed with it, and it will be a disaster. At the same time, the storage area should be equipped with suitable materials to contain leaks, just in case of leakage, and can be dealt with in time to avoid greater harm.
Times and transportation. Before transportation, make sure that the packaging is complete and sealed. If the packaging is damaged, 3-fluoropyridine is easy to leak, which not only pollutes the environment, but also threatens the safety of transportation personnel. During transportation, the speed should not be too fast, nor should it be braked abruptly. Too fast speed and sudden braking can easily cause the container to collide and rub, increasing the risk of leakage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In case of emergencies, they can be responded to in time. And it should not be mixed with the contraindications mentioned above. Follow this rule to ensure safe transportation.