3 Fluoro 5 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

3-Fluoro-5-(trifluoromethyl)pyridine

    Specifications

    HS Code

    277635

    Chemical Formula C6H3F4N
    Molecular Weight 165.09
    Appearance Liquid (usually)
    Boiling Point Around 118 - 120 °C
    Density Data may vary, but around 1.4 g/cm³ (estimated)
    Solubility In Water Low solubility, likely immiscible
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane
    Vapor Pressure Relatively low at room temperature
    Flash Point Data may vary, but potentially flammable

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    General Information
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    Frequently Asked Questions

    As a leading 3-Fluoro-5-(trifluoromethyl)pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3-fluoro-5- (trifluoromethyl) pyridine?
    3-Alene-5- (trienomethyl) pyridine is one of the organic compounds. It has a wide range of uses and has important applications in many fields.
    In the field of medicinal chemistry, this compound is often used as a key intermediate in drug synthesis. Due to its special chemical structure, complex molecular structures with biological activity can be constructed through specific chemical reactions. For example, when developing new antibacterial drugs, 3-ene-5- (trienomethyl) pyridine can be used as a starting material to synthesize drug molecules that have inhibitory or killing effects on specific pathogens through multi-step reactions, contributing to human health and well-being.
    In the field of materials science, it also shows unique value. It can be used to prepare functional materials with special properties. Such as participating in the synthesis of polymer materials, by virtue of their structural properties, the material is endowed with special properties such as good electrical conductivity, optical properties or thermal stability. Such functional materials have broad application prospects in electronic devices, optical instruments and other fields, and help the development of related science and technology industries.
    Furthermore, in the study of organic synthetic chemistry, 3-ene-5- (triene methyl) pyridine is an important synthetic building block. Chemists can use it to perform various organic reactions, such as carbon-carbon bond formation reactions, functional group conversion reactions, etc., to expand the synthesis path of organic compounds, enrich the variety of organic compounds, and promote the progress and innovation of organic synthetic chemistry.
    In summary, 3-ene-5- (trienomethyl) pyridine plays an indispensable role in many fields such as medicine, materials and organic synthesis, and plays an important role in promoting the development of various fields.
    What are the physical properties of 3-fluoro-5- (trifluoromethyl) pyridine?
    3-% hydrocarbon-5- (trihydrocarbon methyl) alkyne is a strange organic compound with unique physical properties.
    Looking at its physical state, under room temperature and pressure, this compound is mostly in a liquid state, with a slightly viscous texture, like a flowing nectar, and a slight ripple when shaken. Its fluidity is slightly slower than that of ordinary light liquids, but it is not as stagnant as a highly viscous substance.
    When it comes to color, pure 3-% hydrocarbon-5- (trihydrocarbon methyl) alkyne is usually almost colorless and transparent, just like a clear crystal, with only a very faint light yellow luster, just like the faint light in the sky when the morning light shines, almost imperceptible.
    When it comes to smell, close to the smell, there will be a unique and elegant fragrance, neither rich and strong fragrance, nor pungent and unpleasant smell, just like the long wood fragrance that pervades the ancient mountains and forests, fresh and unique, giving people a sense of tranquility.
    Again, its density is slightly higher than that of water. When it is carefully poured into the water, it can be seen that it sinks slowly, like a pearl sinking to the bottom, but its density is not too large, still within a measurable reasonable range.
    As for the melting point and boiling point, after careful determination, the melting point is in a certain low temperature range, just like sleeping in the depths of winter, requiring a certain amount of energy from the outside world to wake up; the boiling point is relatively high, requiring strong heat energy to sublimate it from liquid to gaseous, just like phoenix nirvana, which requires tempering by fire.
    Its solubility is also quite interesting. In some organic solvents, such as ethers and aromatics, it can dissolve well, just like a wanderer returning home, and it is difficult to dissolve with the solvent; but in water, the solubility is extremely low, and the two are like incompatible strangers.
    The surface tension of this compound is also unique. On the surface of the liquid, there seems to be an invisible film, which gives it certain elasticity and stability, allowing tiny things to temporarily float on its surface, just like the rolling dew on the lotus leaf, which is round and agile.
    What are the synthesis methods of 3-fluoro-5- (trifluoromethyl) pyridine?
    The synthesis of 3-alkyne-5- (trialkynomethyl) pyridine is an important research direction in the field of organic synthesis. There are many methods, each with its own wonders, which are described in detail below.
    One of them can be synthesized by nucleophilic substitution reaction. First, take a suitable halogenated pyridine derivative and make it meet the nucleophilic reagent containing the alkynyl group. In this nucleophilic reagent, the alkynyl part has strong nucleophilicity and can attack the check point of the halogenated pyridine halogen atom. After the halogenated atom leaves, a carbon-carbon bond is formed, so the pyridine is connected to the alkynyl group. In the future, if trialkynyl groups need to be introduced, the reagents containing trialkynyl groups can be introduced into the system by similar nucleophilic substitution methods to precisely construct the target molecular structure.
    Second, the coupling reaction catalyzed by transition metals is also a good method. Transition metals such as palladium and copper are used as catalysts to interact with pyridine derivatives by halogenates or borates containing alkynyl groups in the presence of specific ligands and bases. Transition metal catalysts can activate the reactants and promote the formation of carbon-carbon bonds. For example, the classic Sonogashira coupling reaction can efficiently couple halogenated pyridines with terminal alkynes under palladium catalysis. Through rational design of reactants, pyridine intermediates containing monoalkynyl groups are prepared first, and then trialkynyl groups are added through subsequent coupling steps, which can achieve the purpose of synthesis.
    Third, the cyclization reaction path is also quite valuable. Compounds containing multiple unsaturated bonds are used as starting materials, and under suitable reaction conditions, they undergo intramolecular cyclization. Through ingenious design of molecular structures, unsaturated bonds selectively interact during the reaction process, and pyridine rings are constructed. At the same time, alkynyl groups and trialkynyl groups are introduced. This method can build a complex molecular skeleton in one step, reduce synthesis steps and improve synthesis efficiency.
    What are the precautions for storing and transporting 3-fluoro-5- (trifluoromethyl) pyridine?
    3-Alkane-5- (trialkyl methyl) alkyne, when storing and transporting, there are several points to pay attention to.
    The first thing to pay attention to is the activity of its chemical properties. This compound contains alkynyl groups and has high reactivity. When exposed to heat, open flame or strong oxidant, it is easy to trigger a violent reaction, and even cause the risk of combustion and explosion. Therefore, when storing, it is necessary to keep away from heat sources, fire sources and oxidants, and choose a cool and ventilated storage. During transportation, it is also necessary to avoid high temperature and open flame, and to prepare fire-extinguishing and explosion-proof utensils.
    The second is related to packaging. Its packaging must be tight and sealed to prevent leakage. The packaging material should also be carefully selected, which must be resistant to the erosion of this compound, and will not be damaged under pressure and vibration. Warning labels should be clearly marked on the outside of the package, such as "flammable" and "explosive", so that the relevant personnel can know the danger at a glance.
    Furthermore, the stability of the transportation process is also important. The transportation vehicle should be driven smoothly to avoid bumps and sudden brakes to avoid the reaction of the compound caused by vibration. And the planning of the transportation route should also be careful to avoid crowded places and important facilities to reduce the harm in the event of accidents.
    During the storage process, the temperature and humidity of the warehouse must be well controlled. High temperature or high humidity environment may affect the stability of this compound. When setting up a temperature and humidity monitoring device, real-time monitoring, if the temperature and humidity exceed the set range, immediate control measures.
    In addition, storage and transportation sites should be guarded by professionals. They need to be familiar with the characteristics, hazards and emergency response methods of this compound. In the event of leakage, fire and other accidents, it can be quickly handled according to the plan to minimize damage.
    What are the effects of 3-fluoro-5- (trifluoromethyl) pyridine on the environment and human health?
    The influence of 3-tetramethylpyridine on the environment and human health is quite important to the world.
    This substance exists in the environment, and its nature or ecology changes. In the aquatic environment, or disturb the reproduction of aquatic animals and plants. Cover it into the water body, or be taken by aquatic organisms, accumulate in the body, causing physiological impairment. Such as the respiratory, reproductive and other functions of fish, or because of it, the number of populations may also be affected by it.
    In the terrestrial domain, if the soil is contaminated with this substance, or the quality of the soil is changed, it will affect the uptake and growth of nutrients by plants. The leaves, stems, flowers, and fruits of plants are all abnormal, causing the appearance of vegetation and ecological balance to be disturbed by it.
    As for human health, its harm is also apparent. If people are exposed to this 3-sulfuric-5- (trisulfuryl) pyridine through breathing, diet, etc., or damage the internal organs of the human body. In the case of lungs, it is responsible for the official organs of respiration, or it is invaded by it, causing dyspnea, cough, etc. The internal organs of the stomach, if the ingestion of drinking water containing this substance, may cause abdominal pain and diarrhea.
    And this substance may be potentially carcinogenic. Long-term exposure to this substance environment, the genes of human cells may be mutated, increasing the risk of cancer. The nervous system may also be damaged, causing people to be in a trance, memory loss, and affecting daily life and labor.
    Therefore, 3-tetramethylpyridine has a significant impact on the environment and human health. It should be handled with caution to prevent it from harming them.