3-ethyl 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate

This is the name of 3-ethyl-5-methyl- (4S) -2,6-dimethyl-4- (3-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylic acid ester. Looking at its name, in order to clarify its chemical structure, we should follow the method of organic chemical structure analysis.
First look at the main chain. This is the structure of dihydropyridine. It is a six-membered nitrogen-containing heterocycle with two double bonds. It forms a bond between the carbons of the 3 and 4 positions to form the skeleton of dihydropyridine. < Br >
Re-view substituent, connected to ethyl at the 3rd position. This ethyl group is a group formed by removing a hydrogen atom from ethane, and is single-bonded to the 3rd carbon of the main chain. The 5th position is connected to methyl group, which is methane with less one hydrogen, and the single bond is connected to the 5th carbon.
At the 4th position, it is a chiral carbon, the configuration is (S), and it is connected with a 3-nitrophenyl group. This phenyl group is a hydrogen removed from the benzene ring, and then a nitro group is connected to the 3rd position of the benzene ring, that is, the -NO 2 group. Each of the 2nd and 6th positions has a methyl substitution.
As for the 3 and 5 positions, each has a carboxylic acid ester structure, the 3 position is -COO-R (where R is ethyl), and the 5 position is -COO-R ' (where R' is methyl). In this way, the chemical structure of this compound is outlined. Its structure is complex, and it is connected to the main chain of dihydropyridine by a variety of groups in specific positions and configurations.

3-Ethyl-5-methyl- (4S) -2,6-dimethyl-4- (3-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate, which is an organic compound. Looking at its structure, its physical properties are quite worthy of investigation.
In terms of appearance, such dihydropyridine derivatives are often in a crystalline solid state. Due to the interaction of van der Waals forces and hydrogen bonds between molecules, the molecules are arranged in an orderly manner and then crystallized. Its color may be white to light yellow, because the chromophore in the molecular structure, such as nitrophenyl, has a certain influence, but the degree of conjugation of the overall structure does not cause the color to be too dark.
Melting point is also an important physical property. The compound has a rigid cyclic structure, and the intermolecular force has a certain strength, so the melting point should be in a certain high range. Specifically, or between 150 ° C and 250 ° C. Due to the interaction of the cyclic structure and the substituent, more energy is required to break the lattice and cause it to melt.
In terms of solubility, because there are both hydrophobic groups such as ester groups and methyl groups in the molecule, and relatively polar parts such as nitrogen-containing heterocycles, the solubility in organic solvents may vary. In polar organic solvents such as ethanol and acetone, or with a certain solubility, the polar part can form hydrogen bonds or dipole-dipole interactions with the solvent; while in non-polar solvents such as n-hexane, the solubility may be lower, due to the weak interaction between hydrophobic groups and non-polar solvents.
Density is closely related to the molecular structure. In view of the types and quantities of carbon, hydrogen, nitrogen, oxygen and other atoms in the molecule, its density may be slightly higher than that of water, and it is estimated that it is between 1.1 and 1.3 g/cm ³. Due to its compact molecular structure, the relative mass and spatial arrangement of atoms make the unit volume mass larger.
The physical properties of this 3-ethyl-5-methyl- (4S) -2,6-dimethyl-4- (3-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylic acid ester are determined by its unique molecular structure and are of great significance in the fields of organic synthesis and drug development, providing a basis for its separation, purification and application.

3 - ethyl + 5 - methyl + (4S) -2,6 - dimethyl - 4 - (3 - nitrophenyl) -3,4 - dihydropyridine - 3,5 - dicarboxylate is an organic compound named 3 - ethyl - 5 - methyl - (4S) -2,6 - dimethyl - 4 - (3 - nitrophenyl) -3,4 - dihydropyridine - 3,5 - dicarboxylate. This substance is mainly used in the fields of organic synthesis and medicinal chemistry. < Br >
In organic synthesis, this compound can be used as a key intermediate to prepare more complex organic molecules through various chemical reactions, such as nucleophilic substitution, cyclization, etc. Because of its special chemical structure, such as nitrogen-containing heterocycles and nitrophenyl groups, it can provide rich activity check points for subsequent reactions, and help to construct various carbon-carbon bonds and carbon-heteroatomic bonds, laying the foundation for the synthesis of novel organic materials.
In the field of medicinal chemistry, such dihydropyridine compounds exhibit significant biological activity. Some dihydropyridine derivatives have calcium channel blocking activity, can regulate the flow of calcium ions inside and outside cells, and have therapeutic potential for cardiovascular diseases, such as hypertension, angina pectoris, etc. This compound may obtain specific pharmacological activities due to structural modification and optimization, and is expected to become a lead compound for the development of new cardiovascular drugs. After in-depth pharmacological research and clinical trials, innovative drugs with better efficacy and fewer side effects may be developed to benefit the majority of patients.

The synthesis of 3-ethyl-5-methyl- (4S) -2,6-dimethyl-4- (3-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate is a key research in the field of chemical synthesis. There are many methods for its synthesis.
First, it can be achieved through the Hantzsch reaction. This reaction is based on ethyl acetoacetate, 3-nitrobenzaldehyde and ammonia (or ammonium salt) as the initial raw materials. Under suitable catalyst and reaction conditions, it goes through many steps such as condensation and cyclization, and finally obtains the target product. The advantage of this route is that the raw materials are easy to obtain and the reaction steps are relatively clear. However, precise control of the reaction conditions is crucial, such as temperature, reaction time, catalyst dosage, etc., which will affect the yield and purity of the product.
Second, the method of organometallic catalysis can also be used. With the help of specific organometallic catalysts, metal complexes such as palladium and copper can promote the coupling reaction of related substrates to construct a pyridine ring structure. The advantage of this approach is that it can achieve more precise synthesis, and the substituents at specific positions can be effectively introduced. However, organometallic catalysts are usually expensive, and the reaction system is relatively complex. Fine adjustment of the reaction conditions is required to avoid the occurrence of side reactions.
Third, other compounds containing pyridine structures can also be considered as starting materials to synthesize the target product through the conversion of functional groups. The key to this method is to find suitable starting materials, and the reaction conditions for the conversion of functional groups are quite high, and it is necessary to ensure the selectivity and yield of the reaction.
Synthesis of 3-ethyl-5-methyl- (4S) -2,6-dimethyl-4- (3-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate There are various methods with advantages and disadvantages. In the actual synthesis process, the most suitable synthesis method should be carefully selected according to the availability of raw materials, the feasibility of reaction conditions, cost considerations, and the requirements for product purity and yield.

I have heard of many scholars, and there is a name "3-ethyl + 5-methyl + (4S) -2,6-dimethyl-4- (3-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate", and I doubt whether it has biological activity. This substance has a complex structure and contains pyridine dihydrogen derivatives, as well as nitrophenyl, ethyl ester, methyl ester and other functional groups.
All kinds of drugs are biologically active due to their specific structures. Pyridine compounds, often in the field of medicine, show extraordinary utility. Its ring structure is stable and can bind to targets in organisms. The nitrophenyl group of this compound can affect the distribution of molecular electron clouds, or enhance its affinity with targets. And its chiral center " (4S) " may cause it to have unique stereoselectivity in organisms, which affects the interaction with biological macromolecules.
However, only looking at its structure, it has not been experimentally verified, so it is difficult to determine. In the past, Shennong tasted a hundred herbs and obtained the properties of various herbs by experimenting with drugs. In order to know the biological activity of this compound, experimental investigation is also required. Cell experiments can be set up to observe its effects on cell growth, proliferation, and apoptosis; animal experiments can also be carried out to observe its pharmacological effects, toxic and side effects.
In summary, based on the available information alone, it is difficult to determine whether "3-ethyl + 5-methyl + (4S) -2,6-dimethyl-4- (3-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate" has biological activity, which needs to be confirmed by experiments.