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What is the chemical structure of 3-ethyl 5-methyl 2- (2-aminoethoxymethyl) -4- (2-chlorophenyl) -1, 4-dihydro-6-methyl-3, 5-pyridinedicarboxylate?
This is the naming of an organic compound. To clarify its chemical structure, it is necessary to disassemble and analyze it according to the naming rules of organic chemistry. " 3 - ethyl ", which means that this compound is attached to ethyl at position 3 of the pyridine ring;" 5 - methyl ", that is, methyl at position 5;" 2 - (2 - aminoethoxymethyl) ", indicating that position 2 is connected with a substituent containing 2 - aminoethoxy methyl;" 4 - (2 - chlorophenyl) ", which means position 4 is connected with 2 - chlorophenyl;" 1,4 - dihydro - 6 - methyl - 3,5 - pyridinedicarboxylate ", indicating that this is a 1,4 - dihydropyridine derivative, and position 6 has methyl, and positions 3 and 5 have a pyridine dicarboxylate structure.
In summary, the chemical structure of this compound is: with 1,4-dihydropyridine ring as the core, ethyl group at position 3, methyl group at position 5, and methyl group at position 6; 2-aminoethoxymethyl group at position 2, 2-chlorophenyl group at position 4; and carboxylic acid ester group at position 3 and 5. Although it is not accurately presented in the diagram, the structure outline can be roughly outlined according to the description. In the field of organic chemistry, such descriptions can help researchers to preliminarily clarify the structural characteristics of compounds, laying the foundation for subsequent research such as property exploration and synthetic path design.
What are the physical properties of 3-ethyl 5-methyl 2- (2-aminoethoxymethyl) -4- (2-chlorophenyl) -1, 4-dihydro-6-methyl-3, 5-pyridinedicarboxylate?
This is 3-ethyl-5-methyl-2- (2-aminoethoxy-methyl) -4- (2-chlorophenyl) -1,4-dihydro-6-methyl-3,5-pyridyldicarboxylate. Its physical properties are as follows:
In terms of appearance, it is often in the state of white to quasi-white crystalline powder. This morphology is quite common in many organic compounds, due to molecular arrangement and crystallization habits.
As for the melting point, after many experiments, it is between 140 and 145 degrees Celsius. The melting point is the inherent characteristic of a substance and is determined by factors such as intermolecular forces and crystal structures. The specific strength of the intermolecular forces of this compound creates such a melting point range.
In terms of solubility, it exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. Because the molecular structure of these organic solvents is compatible with the target compound, it follows the principle of "similarity and miscibility". In water, the solubility is very small, because the polarity of water is quite different from the molecular polarity of the compound, it is difficult for water molecules and compound molecules to form effective interactions. < Br >
The density is usually between 1.2 and 1.3 g/cm ³. The density reflects the mass per unit volume of the substance and is related to the molecular weight and the degree of molecular accumulation. The molecular weight and molecular arrangement of this compound make its density fall within this range.
In terms of stability, it is quite stable under conventional storage conditions, that is, in a cool, dry and dark place. In case of strong acid, strong base or high temperature environment, the structure may change, and reactions such as hydrolysis and decomposition occur. Because strong acid and strong base can provide a check point for reactivity, high temperature increases molecular energy and makes the reaction prone to occur.
What are the main uses of 3-ethyl 5-methyl 2- (2-aminoethoxymethyl) -4- (2-chlorophenyl) -1, 4-dihydro-6-methyl-3, 5-pyridinedicarboxylate?
3 - ethyl + 5 - methyl + 2- (2 - aminoethoxymethyl) - 4- (2 - chlorophenyl) - 1,4 - dihydro - 6 - methyl - 3,5 - pyridinedicarboxylate, which is the name of an organic compound. Its use is quite extensive, commonly found in the field of medical chemistry.
In the process of drug development, such compounds may be used as key intermediates. Because of the specific functional groups contained in the structure, or can interact with targets in vivo. For example, the amino group, chlorophenyl and other parts may participate in the binding of biological macromolecules such as proteins and enzymes, and then exhibit specific biological activities. Scientists use this to explore its potential for treating diseases, such as screening for specific disease-related targets, and it is expected to find lead compounds with therapeutic effects. After subsequent optimization, such compounds may also be useful in the field of materials science. Due to its special chemical structure, it may endow materials with unique properties. For example, it can be introduced into polymer materials as additives to improve the physical and chemical properties of materials, such as improving the stability and solubility of materials, providing the possibility for the development of new functional materials.
Furthermore, in the field of organic synthetic chemistry, it can be used as an important synthetic building block. With its diverse reaction check points, chemists can use various organic reactions to modify and expand their structures, build more complex and functional organic molecules, and promote the development of organic synthetic chemistry, laying the foundation for the creation of more novel and useful compounds.
What are the synthesis methods of 3-ethyl 5-methyl 2- (2-aminoethoxymethyl) -4- (2-chlorophenyl) -1, 4-dihydro-6-methyl-3, 5-pyridinedicarboxylate?
This is an organic compound 3 - ethyl - 5 - methyl - 2 - (2 - aminoethoxy methyl) - 4 - (2 - chlorophenyl) - 1,4 - dihydro - 6 - methyl - 3,5 - pyridinedicarboxylate synthesis method. The method of synthesis may follow multiple paths.
First, a pyridine derivative is used as the starting material, and a 2 - aminoethoxy methyl group is introduced through etherification reaction. First, appropriate pyridine derivatives are taken, placed in a reactor, an appropriate amount of base is added to activate its check point, and then 2-aminoethoxy methylation reagent is slowly added dropwise, and the ether bond is successfully constructed at a specific temperature and time.
Then, nucleophilic substitution of halogenated benzene is carried out. Select 2-chlorophenyl reagent, mix with the above reaction products, add suitable catalyst and base, heat and stir to promote the smooth occurrence of nucleophilic substitution, and introduce 2-chlorophenyl into the molecular structure.
Furthermore, for the construction and modification of dihydropyridine. Through a suitable condensation reaction, the corresponding esters and nitrogen-containing compounds are selected, and the 1,4-dihydropyridine ring structure is formed by cyclization and condensation under the catalysis of acid or base. During the period, according to the requirements of the target product, 3-ethyl, 5-methyl, 6-methyl and other alkyl groups are introduced in a timely manner to regulate the reaction conditions to ensure the precise integration of each group.
Or the core structure of the dihydropyridine ring can be constructed first, and then the side chain can be gradually modified. First synthesize the basic skeleton of 1,4-dihydropyridine-3,5-dicarboxylate, and then introduce the 2-position and 4-position substituents in turn to complete the connection of 2- (2-aminoethoxy methyl) and 4- (2-chlorophenyl), respectively. All steps of the reaction need to be controlled by conditions to ensure the purity and yield of the product.
Synthesis requires detailed study of the reaction mechanism of each step, precise regulation of temperature, time, material ratio and other factors, in order to obtain the target compound 3-ethyl-5-methyl-2 - (2-aminoethoxymethyl) -4- (2-chlorophenyl) -1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate efficiently and with high quality.
3-Ethyl 5-methyl 2- (2-aminoethoxymethyl) -4- (2-chlorophenyl) -1, 4-dihydro-6-methyl-3, 5-pyridinedicarboxylate What are the precautions during use?
3 - ethyl + 5 - methyl + 2 - (2 - aminoethoxymethyl) - 4 - (2 - chlorophenyl) - 1,4 - dihydro - 6 - methyl - 3,5 - pyridinedicarboxylate is a complex organic compound. During use, the following matters must be paid attention to.
First, this compound may have specific chemical activity and reactivity. When operating, it is necessary to precisely control the reaction conditions, such as temperature, pH and reaction time. If the temperature is too high or the reaction is out of control, or side reactions are triggered, the purity of the product is reduced; if the temperature is too low, the reaction rate will be slow, which will affect the production efficiency. Similarly, the deviation of pH can also have a significant impact on the reaction process and product quality.
Second, due to its complex structure, its solubility also needs to be considered in detail. It is essential to choose a suitable solvent. The solvent must not only be able to dissolve the compound well to ensure that the reaction is homogeneous, but also need to not have additional chemical reactions with the reactants and products. Otherwise, it may cause the reaction to be difficult to advance, or even produce the wrong product.
Third, safety issues should not be underestimated. Although the specific toxicity of this compound is not known, most organic compounds may be toxic, irritating or corrosive. When operating, safety procedures must be strictly followed, and appropriate protective equipment must be worn, such as gloves, goggles and protective clothing, to prevent the compound from contacting the skin and eyes. At the same time, the operation should be carried out in a well-ventilated environment to avoid inhalation of volatile gaseous substances.
Fourth, storage should also be cautious. It is necessary to choose the appropriate storage conditions according to its chemical properties. Generally speaking, it should be stored in a cool and dry place, avoiding light and high temperature, to prevent the compound from deteriorating or chemical reaction, and to ensure its quality and stability.
In short, when using this compound, from the control of reaction conditions, solvent selection, to safety protection and storage, every link is related to the success or failure of the experiment and the safety of the operator.