3-(Ethoxycarbonyl)-5-hydroxypyridine

3 - (ethoxycarbonyl) - 5 -hydroxypyridine, this is an organic compound. It has unique chemical properties and is of great significance to organic synthesis chemistry.
Discusses the physical properties, under normal conditions, or as a solid state, but the specific properties are also affected by impurities and environmental factors. The determination of melting point and boiling point is indispensable for the identification and purification of this compound. However, its exact value needs to be determined by specific experiments. Due to different experimental conditions, such as heating rate and sample purity, the results will be biased.
Looking at its chemical properties, due to the structure containing hydroxyl groups and ethoxycarbonyl groups, the two give the compound many active reaction check points. The hydroxyl group is a nucleophilic group and can participate in the esterification reaction. Under suitable catalyst and reaction conditions, it interacts with acid to form corresponding ester compounds. In this reaction, the oxygen atom of the hydroxyl group attacks the carbonyl carbon of the acid with its lone pair of electrons, and goes through complex reaction steps to form a new ester bond. In the
ethoxycarbonyl group, the carbonyl group has strong electron absorption, which enhances the acidity of the α-hydrogen atom connected to it. Under the action of alkali, α-hydrogen easily leaves in the form of protons to form carbon negative ion intermediates. This intermediate is active and can react with many electrophilic reagents, such as halogenated hydrocarbons, to achieve molecular carbon chain growth or structural modification.
Furthermore, the presence of pyridine rings also affects the chemical behavior of the compound. Pyridine rings have certain aromatic and basic properties, and can be protonated with acids to form pyridine salts. This property can be used to regulate the solubility and reactivity of compounds.
In addition, 3- (ethoxycarbonyl) -5-hydroxypyridine can be used as a key intermediate for the synthesis of complex natural products, drugs and functional materials due to its multiple reactive functional groups. In the field of organic synthesis, chemists use ingenious design of reaction routes and use their chemical properties to achieve efficient construction of target compounds.

3- (ethoxycarbonyl) -5-hydroxypyridine is one of the important members in the field of organic compounds. Its unique physical properties have attracted much attention in the fields of scientific research and industrial applications.
Looking at its properties, at room temperature, this substance is mostly in the state of white to light yellow crystalline powder, delicate and uniform, and often glows softly under light. This form is easy to store and use, and also lays the foundation for its role in various reaction systems.
When it comes to melting point, the melting point of 3- (ethoxycarbonyl) -5-hydroxypyridine is in a specific range, generally speaking, about [X] ° C. The stability of the melting point reflects the characteristics of the intermolecular forces of the compound, which has a profound impact on its stability and phase changes in high temperature environments. The accurate determination of the melting point provides key parameters for its synthesis, purification and quality control.
In terms of solubility, this compound exhibits good solubility in some organic solvents. For example, in common organic solvents such as ethanol and acetone, it can be moderately dissolved. This property allows it to be effectively dispersed in the reaction medium in the organic synthesis reaction and promotes the smooth progress of the reaction. In water, its solubility is relatively limited. Such a difference in solubility helps to separate and purify it by means of solvent extraction.
The density of 3- (ethoxycarbonyl) -5-hydroxypyridine also has a specific value, which is about [X] g/cm ³. Density, as one of the basic physical properties of substances, plays an important role in the measurement and mixing ratio of materials in chemical production, and is indispensable to ensure the uniformity of product quality.
In addition, the stability of this compound cannot be ignored. Under normal storage conditions, in a dry and cool place, 3- (ethoxycarbonyl) -5-hydroxypyridine can maintain a relatively stable chemical structure. However, in case of extreme chemical environments such as strong acids and bases, or harsh physical conditions such as high temperature and high humidity, its structure may change, triggering chemical reactions and resulting in performance changes. Therefore, during storage and use, it is necessary to operate cautiously and store properly according to its physical properties to ensure its quality and application effect.

3- (ethoxycarbonyl) -5-hydroxypyridine, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Due to the unique structure of the pyridine ring with hydroxyl and ethoxycarbonyl groups, the compound is endowed with specific biological activities and reaction characteristics. By modifying and derivatizing its structure, a series of compounds with potential medicinal value can be synthesized. For example, using 3- (ethoxycarbonyl) -5-hydroxypyridine as the starting material, through appropriate reaction steps, drug molecules that can interact with specific disease-related targets may be constructed for the development of new therapeutic drugs, such as anti-cancer and anti-inflammatory drugs. < Br >
In the field of materials science, it also plays an important role. By virtue of its own structural properties, it may participate in the synthesis of certain functional materials. For example, it can be combined or polymerized with other organic or inorganic materials to prepare materials with special optical, electrical or thermal properties. In the field of optoelectronic materials, it may be used as a construction unit to improve the charge transport properties and luminescence properties of materials, and provide assistance for the development of new optoelectronic devices, such as organic Light Emitting Diodes (OLEDs) and solar cells.
In the field of organic synthesis chemistry, 3- (ethoxycarbonyl) -5-hydroxypyridine is used as a multifunctional intermediate to provide a convenient way for the synthesis of complex organic molecules. The functional groups contained in it can participate in a variety of classical organic reactions, such as esterification, nucleophilic substitution, and oxidation-reduction reactions. With this, chemists can ingeniously design reaction routes to synthesize organic compounds with specific structures and functions, greatly enriching the types and properties of organic compounds, and promoting the development of organic synthetic chemistry.

The synthesis of 3- (ethoxycarbonyl) -5-hydroxypyridine is an important research direction in the field of organic synthesis. There are various synthesis paths, and the common methods are described in detail below.
First, it can be obtained by the conversion of functional groups of pyridine derivatives. Using 5-hydroxypyridine as the starting material, its high hydroxyl activity can be used to initiate the reaction. 5-hydroxypyridine reacts with diethyl carbonate under the catalysis of a base. The alkali can be selected from potassium carbonate, sodium carbonate and other common inorganic bases. In a suitable organic solvent, such as N, N-dimethylformamide (DMF), it is heated to a certain temperature, usually at 80-120 ° C, and the reaction is carried out for several hours. In this process, the ethoxycarbonyl group of diethyl carbonate will replace the hydrogen atom on 5-hydroxypyridine, and then the target product 3 - (ethoxycarbonyl) - 5-hydroxypyridine will be formed. The reaction formula is roughly as follows: 5-hydroxypyridine + diethyl carbonate + base (such as potassium carbonate) → 3- (ethoxycarbonyl) - 5-hydroxypyridine + by-products (such as ethanol, carbon dioxide, etc.). The key to this reaction is that the amount of base needs to be precisely regulated, and too much or too little will affect the reaction yield.
Secondly, it can also be achieved by the strategy of constructing a pyridine ring. Start with suitable nitrogenous and oxygenated feedstocks, such as some beta-ketoates with appropriate substituents reacting with ammonia or amines. Under the catalysis of acid or base, a cyclization reaction occurs first to form a pyridine ring, and ethoxycarbonyl and hydroxyl groups are introduced at the same time. Specifically, the β-ketoate containing ethoxycarbonyl and the amine containing hydroxyl substituents are selected, and the reaction is heated and refluxed under the catalysis of weak acids such as acetic acid. This process is relatively complex and involves a multi-step reaction mechanism, such as nucleophilic addition and elimination reactions, etc., and finally 3 - (ethoxycarbonyl) -5 -hydroxypyridine is generated. Although this method is a little complicated, the reaction conditions can be flexibly adjusted according to the characteristics of the raw materials to optimize the yield and purity of the product.
Furthermore, the reaction catalyzed by transition metals can also be used. Using halogenated pyridine derivatives as raw materials, carbonylation with carbon monoxide and ethanol occurs under the action of transition metal catalysts such as palladium catalysts. Appropriate ligands need to be added to the reaction system to enhance the activity and selectivity of the catalyst. At the same time, conditions such as pressure, reaction temperature and time of carbon monoxide need to be controlled. This method has the advantages of mild reaction conditions and high selectivity, and can efficiently synthesize 3- (ethoxycarbonyl) -5-hydroxypyridine.
The above synthesis methods have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider factors such as the availability of raw materials, cost, reaction conditions and requirements for product purity, and make careful choices to achieve efficient and economical synthesis goals.

3 - (ethoxycarbonyl) - 5 -hydroxypyridine, this is an organic compound, and many things need to be paid attention to when storing and transporting.
Bear the brunt, and the storage environment must be dry and cool. Because of its certain hygroscopicity, if the environment is humid, it is prone to moisture and deterioration, causing its purity and quality to decline. And excessive temperature may also cause chemical reactions, so it should be stored in a well-ventilated place to avoid high temperature to prevent heat accumulation.
Furthermore, this compound is more sensitive to light. Light may cause photochemical reactions to occur, resulting in changes in structure and properties. Therefore, when storing, you should choose a light-shielding container, such as a brown glass bottle, or store it in a dark place to block light intrusion.
When transporting, the packaging must be solid and stable. This compound may be dangerous, and improper packaging is prone to leakage, posing a threat to personnel and the environment. Suitable packaging materials, such as strong plastic drums or special metal containers, should be selected and properly fixed to prevent collision and damage during transportation.
At the same time, relevant regulations and standards must be strictly followed. Whether it is storage or transportation, it should comply with chemical management regulations, and operators should also be professionally trained to be familiar with the properties of the compound and emergency treatment methods. In the event of an accident, they can respond quickly and properly.
In addition, attention should be paid to isolation from other substances. 3- (ethoxycarbonyl) -5-hydroxypyridine may react with certain substances. During storage and transportation, contact with oxidizing, reducing substances, acids, bases, etc. should be avoided to prevent adverse reactions.