3-Cyanopyridine-4-boronic acid pinacol ester

3-Aminopyridine and 4-pyridine sulfonic acid are both pyridine derivatives, each with unique chemical properties.
3-aminopyridine, whose amino group is attached to the 3rd position of the pyridine ring. The amino group has electron-giving properties, which increases the electron cloud density of the pyridine ring, enhances the activity of electrophilic substitution reaction, and the amino group can participate in many reactions, such as salting with acids. Because the amino lone pair electron can bind to the proton, 3-aminopyridine has a certain alkalinity. In organic synthesis, it is often used as an intermediate to participate in the construction of nitrogen-containing heterocyclic compounds.
4-pyridine sulfonic acid, the sulfonic acid group is attached to the 4th position of the pyridine ring. The sulfonic acid group is a strong electron-absorbing group, which reduces the electron cloud density of the pyridine ring and weakens the activity of electrophilic substitution. Sulfonic acid is basically acidic, and 4-pyridine sulfonic acid can ionize hydrogen ions in water, which is acidic and can neutralize with bases to form corresponding salts. Its sulfonic acid groups can be converted into other functional groups through specific reactions, and are widely used in organic synthesis and medicinal chemistry. For example, it is used as a check point for the modification of the molecular structure of some drugs to change the water solubility and biological activity of compounds.
The chemical properties of the two are significantly different, due to the different characteristics of the linked functional groups. One is an electron-giving amino group and the other is an electron-withdrawing sulfonic acid group, which have different effects on the electron cloud distribution of the pyridine ring, resulting in different reactivity and acid-base characteristics. They have unique applications in chemical research and industrial production.

The main uses of 3-hydroxypyridine-4-sulfonate are:
3-hydroxypyridine, which has a wide range of uses. In the field of medicine, it is a key intermediate in the synthesis of many drugs. For example, it can be used to prepare drugs with antibacterial and anti-inflammatory effects. Because of its unique chemical structure, it can interact with specific biological targets to exert pharmacological activity. In the field of materials science, it can participate in the synthesis of functional polymer materials. By polymerizing with other monomers, it imparts special properties to materials, such as improving the hydrophilicity of materials and improving the stability of materials. In addition, in organic synthetic chemistry, it is often used as a basic module for building complex organic molecules. With the reactivity of its hydroxyl groups, various functional group conversion reactions are carried out to construct diverse organic compound structures.
4-sulfonate, occupies an important position in the field of organic synthesis. First, it is often used as an excellent leaving group to participate in nucleophilic substitution reactions. Due to the moderate stability of sulfonate groups, under appropriate reaction conditions, it is easily replaced by nucleophiles, thereby realizing the construction of carbon-carbon bonds and carbon-heteroatomic bonds, which are frequently used in the total synthesis of complex natural products and drug synthesis processes. Second, it also contributes to the preparation of surfactants. The introduction of sulfonate groups can endow compounds with amphiphilicity, making them capable of reducing surface tension, and then applied to the manufacture of detergents, emulsifiers and other products. Thirdly, in the dye industry, sulfonate groups can be introduced into dye molecules to improve the solubility and dyeing properties of dyes, and enhance the affinity and dyeing fastness of dyes to different fiber materials.

The synthesis of methyl 3-aminopyridine-4-sulfonate is an important topic in the field of organic synthesis. To obtain this compound, the following ancient method can be followed:
At the beginning, the suitable pyridine derivative is used as the starting material. If a specific substituted pyridine is selected, the substituent on it needs to be carefully selected so that the subsequent reaction can be carried out. The pyridine derivative is first reacted with the appropriate amination reagent under specific reaction conditions. This amination reaction requires careful control of the temperature, time and proportion of the reactants. Usually, under mild heating conditions, the reactants are fully mixed in a suitable solvent. The selected solvent has good solubility to the reactants and does not unnecessarily react with the reactants. After this step of reaction, amino groups can be introduced at specific positions in the pyridine ring to obtain amino-containing pyridine intermediates.
Then, the resulting intermediate is sulfonated. In this step, it is crucial to select an appropriate sulfonate methyl esterification reagent. The amino-containing pyridine intermediate is reacted with the sulfonate methyl esterification reagent in the presence of a catalyst. The type and amount of catalyst have a great impact on the rate and selectivity of the reaction. Generally, certain Lewis acids can be selected as catalysts to successfully synthesize 3-aminopyridine-4-sulfonate methyl ester by promoting the smooth connection of methyl sulfonate groups to the target position of the pyridine ring within a suitable temperature and reaction time.
The whole synthesis process requires fine control of the conditions of each step of the reaction, including temperature, pH, and the purity of the reactants, in order to improve the yield and purity of the product and achieve the purpose of efficient synthesis of 3-aminopyridine-4-sulfonate methyl ester.

When storing 3-hydroxypyridine and 4-thiophene sulfonic acid, many precautions must be taken during storage and transportation.
3-hydroxypyridine has certain chemical activity. When storing it, choose a cool, dry and well-ventilated place. Cover it because it may be easy to absorb moisture. After absorbing moisture, it may affect its chemical properties and cause changes in quality. And it needs to be kept away from fires and heat sources to prevent it from reacting chemically due to heat, or even causing danger. Storage should be separated from oxidants, acids, bases, etc., and must not be mixed. It is easy to react with such substances and cause unexpected changes. Packaging should also be tight to ensure no leakage.
As for the transportation, it is necessary to choose the appropriate transportation method according to its chemical characteristics. The transportation vehicle should have good ventilation equipment to disperse the harmful gases that may be generated. During transportation, be sure to protect against sun exposure, rain, and high temperature. When loading and unloading, the operator should handle it lightly, so as not to damage the packaging and cause material leakage.
4-thiophene sulfonic acid, storage also needs to be low temperature, dry and ventilated. Because of its acidic nature, it has the ability to corrode certain materials, so the storage container should be selected to be corrosion-resistant, such as specific plastic materials or specially treated metal containers. The storage area should be equipped with suitable containment materials in case of leakage.
When transporting 4-thiophenesulfonic acid, it should be transported according to the regulations of dangerous chemicals. The means of transportation should have obvious warning signs to inform others of its danger. Transportation personnel should be professionally trained and familiar with emergency handling methods. During transportation, pay close attention to the status of the goods. If there is any leakage, immediately deal with it according to the predetermined emergency plan to ensure the safety of personnel and the environment.

The market price range of 3-hydroxypyridine-4-sulfonic acid is related to many factors, and it is difficult to sum it up.
The price in the city often varies depending on the quality, origin, and supply and demand. If these two products are of high quality, come from good places, and are widely available in the market, and the supply is thin, the price will be higher; conversely, if the quality is average, the origin is ordinary, and the supply is full and the demand is weak, the price may be lower.
Generally speaking, the market price of 3-hydroxypyridine-4-sulfonic acid is between tens of yuan and hundreds of yuan per kilogram. However, this is only an approximate number, and the actual price may change from time to time, or vary according to the transaction situation.
In today's world, the price of chemical products is subject to the cost of raw materials, production processes, and transportation costs. If the price of raw materials is high, the process is complicated, and the transportation is difficult, the price of the product will also rise accordingly; on the contrary, if the raw materials are cheap, the process is simple, and the transportation is convenient, the price may be reduced.
Therefore, if you want to know the exact market price range, you must consult chemical product suppliers, traders, or refer to relevant industry reports and market surveys to obtain the exact number. When purchasing, it is also advisable to make more comparisons, check the quality carefully, and ensure that the purchased goods are of high quality at a reasonable price.