3-Cyano-5-hydroxypyridine

3-Cyano-5-hydroxypyridine has a wide range of uses in the chemical and pharmaceutical fields.
In the chemical field, one of them can be used as an intermediary for organic synthesis. To cover the technique of organic synthesis, various intermediates are often needed to construct complex molecular structures. 3-Cyano-5-hydroxypyridine has a special chemical structure, and its cyano and hydroxyl groups are reactive. It can combine with other compounds through various chemical reactions, such as nucleophilic substitution, addition, etc., to obtain a variety of organic compounds. For example, it can be reacted with halogenated hydrocarbons through nucleophilic substitution, introducing specific substituents, expanding the structure of molecules, and laying the foundation for the synthesis of organic materials with special functions.
Second, in the process of pharmaceutical research and development, this compound also has important functions. Due to its special structure, it may exhibit specific biological activities. Pharmacists often use this as a starting material to develop new compounds with pharmacological activity through modification and modification. Or drug molecules with potential therapeutic effects can be designed and synthesized for specific disease targets. For example, by modifying its structure, it may be able to combine with specific proteins or enzymes to regulate physiological processes in organisms and achieve the purpose of treating diseases.
Furthermore, in the field of materials science, 3-cyano-5-hydroxypyridine may participate in the synthesis of functional materials. After appropriate reaction, it can be introduced into the structure of polymer materials, which may endow the materials with unique physical and chemical properties, such as improving the optical and electrical properties of the materials, thus contributing to the creation of new materials.

3-Cyano-5-hydroxypyridine is one of the organic compounds. Its physical properties are quite impressive.
In terms of its appearance, it is often in the form of white to light yellow crystalline powder, which is easy to observe and handle. As far as the melting point is concerned, at a specific temperature range, this characteristic is crucial for identification and purity judgment, because the accurate determination of the melting point can reflect its purity.
Solubility is also one of the key physical properties. In organic solvents such as ethanol and dichloromethane, 3-cyano-5-hydroxypyridine exhibits a certain solubility, but the solubility in water is relatively low. This difference in solubility can be used to achieve effective separation in the separation and purification steps of chemical synthesis.
Furthermore, its density is also a specific value. Although it is not very prominent in daily cognition, density data is indispensable when accurately calculating the amount of materials in chemical production and related experiments. In addition, the compound is relatively stable under normal temperature and pressure, and it is not prone to spontaneous violent chemical reactions. This stability provides convenience for its storage and transportation. Just follow the storage conditions of general organic compounds, such as placing in a dry, cool place, avoiding contact with strong oxidants, strong acids and alkalis, etc., to ensure its quality. All these physical properties lay the foundation for the in-depth understanding and rational use of 3-cyano-5-hydroxypyridine.

The synthesis method of 3-cyano-5-hydroxypyridine has been known in ancient times, and the methods are various. The following are detailed by you.
First, it can be obtained by the conversion of a compound containing a pyridine ring through a specific reaction. First take a suitable pyridine derivative, which needs a group that can be substituted or modified on the ring. In a suitable reaction vessel, add this pyridine derivative, and then add a cyanide-containing reagent, such as potassium cyanide, etc. Under a basic environment and a certain temperature, the cyanide group can replace the group at a specific position on the pyridine ring to form a cyanide-containing pyridine intermediate. Subsequently, through appropriate oxidation or hydrolysis reactions, hydroxyl groups are introduced into another position of the pyridine ring to obtain 3-cyano-5-hydroxypyridine. This process requires fine regulation of reaction conditions, such as temperature, reaction time and reagent dosage, in order to obtain higher yields.
Second, the strategy of constructing the pyridine ring by multi-step reaction is also feasible. First, small molecule compounds are used as starting materials, and the pyridine ring skeleton is gradually constructed through reactions such as condensation and cyclization. For example, compounds containing functional groups such as carbonyl and amino groups are selected to undergo condensation reactions under the action of catalysts to form intermediates with the prototype of the pyridine ring. Then, through the steps of introducing cyanyl groups and hydroxyl groups, the corresponding groups are modified at specific positions of the pyridine ring, and the final product is obtained. Although this method is complicated, it can flexibly design the reaction route and achieve precise control of the product structure.
Third, the synthesis is catalyzed by transition metals. Transition metal catalysts such as palladium and copper can promote the functionalization of the pyridine ring. The suitable pyridine substrate is reacted with the source reagents containing cyanide and hydroxyl groups in a suitable solvent in the presence of transition metal catalysts and ligands. The catalyst can reduce the activation energy of the reaction, so that the cyanide group and hydroxyl group are precisely connected to the target position of the pyridine ring. This method has the advantages of mild reaction conditions and high selectivity, but the catalyst cost is high, and the advantages and disadvantages need to be weighed.
There are many methods for synthesizing 3-cyano-5-hydroxypyridine, each with its advantages and disadvantages. The appropriate synthesis path should be carefully selected according to actual needs and conditions.

The price of 3-Cyano-5-hydroxypyridine in the market often changes for a variety of reasons. The price involves the availability of raw materials, the simplicity of the process, the situation of supply and demand, and even the change of the current situation.
Looking at the past, the abundance of raw materials is really the key to its price. If raw materials are easily available and inexpensive, the cost of this product may decrease, and the price will also decrease. On the contrary, if raw materials are scarce and difficult to find, the price will be high.
The simplicity of the process also affects its price. If the technology is refined and easy, and the working hours and energy consumption are small, the price may be close to the people; if the technology is complicated, requires multiple steps, and has strict requirements for equipment and skills, the price will be high.
The trend of supply and demand is particularly critical. If there are many people in the market who want it, but the supply is small, the price will rise; if the supply exceeds the demand, the merchants will compete for it, and the price will decline.
As for the changes in the current situation, such as the issuance of decrees, trade regulations, natural and man-made disasters, etc., it can disrupt its production and circulation, and then move its price.
However, as far as I know, the price in the market is between a few yuan and tens of yuan per gram. This is only an approximate amount, and the actual price should be subject to the current market conditions. And different quality and different suppliers have different prices. To know the exact price, you must check the inter-city reports and consult the suppliers before you can get it.

3-Cyano-5-hydroxypyridine, this is an organic compound. The most important thing for its storage is to ensure a suitable storage environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. This is to avoid changes or chemical reactions caused by excessive temperature or humidity.
Furthermore, it should be stored separately from oxidizing agents, acids, bases and other substances. Due to the chemical properties of 3-cyano-5-hydroxypyridine, it is easy to react chemically with the above-mentioned substances, and it is dangerous to store mixed with them. The storage place needs to be prepared with suitable materials to contain possible leakage. < Br >
Packaging should also be rigorous. Sealed packaging should be used to prevent it from deteriorating in contact with air. After use, it must be sealed in time to maintain the integrity of the package. In this way, the stability and quality of 3-cyano-5-hydroxypyridine during storage are guaranteed for subsequent use.