3-cyano-5-fluoro-2,6-Dihydroxypyridine

3-Amino-5-bromo-2,6-difluoropyridine is an important organic compound with a wide range of uses in the field of organic synthesis. Its main uses are as follows:
- ** Drug Synthesis **: It can be used as a key intermediate for the creation of a variety of drugs. Due to its special chemical structure, it can endow drugs with unique biological activities and pharmacological properties. For example, in the synthesis of some antibacterial drugs, with its amino, bromine and fluorine atoms, it can enhance the inhibition and killing ability of drugs against specific bacteria, and at the same time improve the absorption, distribution, metabolism and excretion process of drugs in the body, improve drug efficacy and reduce toxic and side effects. < Br > - ** Material Science **: In the research and development of new materials, 3-amino-5-bromo-2,6-difluoropyridine can play a key role. For example, when preparing organic materials with special photoelectric properties, introducing them into the molecular structure of the material can adjust the electron cloud distribution of the material and change its optical absorption and emission characteristics, so as to obtain high-performance materials suitable for photoelectric devices such as organic Light Emitting Diode (OLED) and solar cells, and improve the luminous efficiency, stability and photoelectric conversion efficiency of the device.
- ** Pesticide Synthesis **: Participate in the creation of pesticides as intermediates. Using its structural characteristics, pesticides that are highly toxic to pests and environmentally friendly can be synthesized. For example, for the nerve conduction or growth and development process of some specific pests, the design and synthesis of pesticides based on this compound can achieve the purpose of efficient pest control by precisely acting on the physiological targets of pests, while reducing the negative impact on non-target organisms and the environment.
In summary, 3-amino-5-bromo-2,6-difluoropyridine, with its unique chemical structure, plays an indispensable role in many fields such as drugs, materials and pesticides, and is of great significance to promote technological innovation and industrial development in related fields.

To prepare 3-amino-5-bromo-2,6-difluoropyridine, there are many methods, which can be done according to various principles and paths.
First, the method of substituting halopyridine with nucleophilic substitution. Halopyridine meets with an amino-containing reagent under specific conditions, and the amino group can replace the halogen atom. If 2,6-difluoropyridine and ammonia or amine reagents are used at suitable temperatures, pressures and catalysts, the amino group can be selected to replace the halogen atom to obtain the target product. Among them, the activity of the halogen atom, the nucleophilicity of the reagent, and the reaction conditions are all key, and careful regulation is required to make the reaction go smoothly and with good selectivity.
Second, pyridine derivatives are used as the starting material and converted through multiple steps. First, pyridine is cyclic halogenated, fluorine and bromine atoms are introduced, and then functional group conversion is used to add amino groups. For example, pyridine is used as the starting point, and fluorine and bromine-containing pyridine derivatives are obtained through halogenation reaction. After nitration and reduction, the nitro group is converted into an amino group. This path is complicated, but the reaction of each step is highly controllable. If properly planned, the product can also be efficiently prepared.
Third, the method of cyclization reaction is adopted. The chain compound with a specific structure is used as raw material, and the pyridine ring is constructed by intramolecular cyclization, and the required amino and halogen atoms are introduced at the same time. For example, the chain compound containing nitrogen and halogen is cyclized and condensed in a suitable catalyst and reaction medium to form a pyridine ring to obtain the target product. This path design is exquisite and can simplify the process. However, the structure requirements of the raw materials are strict, and the synthesis route needs to be carefully designed.
All synthesis methods have their own advantages and disadvantages. In practical application, when the optimal method is selected according to various factors such as the availability of raw materials, cost, difficulty of reaction conditions, and the purity and yield of the product, 3-amino-5-bromo-2,6-difluoropyridine can be efficiently and economically prepared.

3-Amino-5-bromo-2,6-difluoropyridine, which has unique physical properties and various characteristics. Its color state is often white to light yellow crystalline powder, which is fine and uniform in appearance, under light or shimmer.
When it comes to the melting point, it is about a specific range. This value is crucial to the transformation of its morphology in a specific process, and it is related to whether the reaction process and product purity can be accurately regulated. Its solubility also has characteristics. It is soluble in some organic solvents, such as common ethanol, acetone, etc., but it is not well soluble in water. This characteristic needs to be carefully considered in the separation, purification and preparation of preparations, and the solvent should be selected reasonably to achieve the desired effect.
The stability of this compound is very important. Under normal temperature and pressure, its chemical properties are relatively stable and can be properly stored. However, under extreme conditions such as strong acid, strong base or high temperature, strong oxidant, the structure is easily damaged and chemical reactions are triggered. Therefore, when storing and using, it is necessary to avoid such environments to prevent deterioration.
In terms of reactivity, the presence of amino groups, bromine atoms and fluorine atoms in its molecular structure endows it with high reactivity. Amino groups can participate in many nucleophilic substitution reactions. Bromine atoms, as a good leaving group, can initiate various substitution and coupling reactions. Fluorine atoms can enhance the density of molecular electron clouds and affect the selectivity and rate of reactions. This reactivity makes it widely used in the field of organic synthesis and a key intermediate for the preparation of a variety of complex organic compounds.

3-Amino-5-bromo-2,6-difluoropyridine, which has multiple chemical properties. It is basic because its amino group can bind protons. In the field of organic synthesis, amino groups can participate in many reactions, such as reacting with acyl halides and acid anhydrides to form amides. This reaction is a common means to construct nitrogen-containing organic molecular structures.
5-bromo atoms are highly active and can carry out nucleophilic substitution reactions. For example, under appropriate conditions, they are replaced by nucleophiles such as hydroxyl, alkoxy, and amino groups, whereby different functional groups can be introduced to expand the structural diversity of compounds, which is of great significance for the synthesis of complex organic molecules. < Br >
2,6-difluoro groups affect the distribution of molecular electron clouds, which change the density of pyridine ring electron clouds and affect their reactivity and selectivity. At the same time, fluorine atoms have high electronegativity, which can enhance molecular stability and affect the physical and chemical properties of compounds. In medicinal chemistry, fluorine-containing compounds often exhibit unique biological activities and pharmacokinetic properties due to the special properties of fluorine atoms.
This compound can also participate in metal-catalyzed coupling reactions, such as palladium-catalyzed cross-coupling reactions. Through such reactions, the structure of pyridine can be connected with other organic fragments to construct organic materials or bioactive molecules with novel structures and specific functions. It has potential application value in the fields of materials science, drug development, and pesticide creation, and can be used as a key intermediate to assist in the synthesis of many valuable compounds.

What is the price of 3-hydroxy-5-chloro-2,6-difluorobenzaldehyde on the market today? This is an important raw material for fine chemicals, and its price range is related to many considerations.
Looking at the acquisition of its raw materials, if the raw materials are easy to obtain and affordable, the cost of its production will decrease, and the price will follow. However, if the raw materials are scarce and difficult to find, or difficult to harvest and cumbersome to make, the cost will rise and the price will be high.
Furthermore, depending on the production process. If the process is simple and efficient, with low energy consumption, high yield, and the price is close to the people; if the process is complicated, high-end equipment, multiple processes are required, and a lot of manpower and material resources are required, the price will be high.
And the market supply and demand situation is also the key. If there are many people who want it, the supply is small, and the supply is in short supply, and the price is self-increasing; if the supply is excessive, the merchant will sell its goods or reduce the price.
Under normal circumstances, this 3-hydroxy-5-chloro-2,6-difluorobenzaldehyde is priced per kilogram on the market or between hundreds and thousands of yuan. However, this is only an approximation. The market conditions are changing rapidly, and the price also fluctuates with raw materials, processes, supply and demand. The actual price needs to be consulted with chemical raw material merchants, or the real-time market conditions can only be determined.