3-Cyano-4-methylpyridine

3-Hydroxy-4-methylpyridine has many main uses. In the field of medicine, this compound is often a key raw material for the creation of drugs. Due to its unique chemical structure, it endows many pharmacological activities. Or it can be used to develop antibacterial drugs to resist the invasion of various pathogens and help human health. Or it can play an important role in the development of antiviral drugs, providing assistance for the fight against the ravages of viruses.
In the field of materials science, 3-hydroxy-4-methylpyridine also has extraordinary value. It can be used as an important intermediate in organic synthesis to prepare polymer materials with special properties. Such materials may have excellent stability, conductivity, or special optical properties, and have broad application prospects in many fields such as electronic devices and optical instruments.
Furthermore, in chemical production, it is also an indispensable component. Or participate in the preparation of catalysts, with its unique chemical properties, improve the efficiency and selectivity of chemical reactions, make chemical production more efficient and accurate, and reduce the waste of resources and the generation of by-products.
In short, 3-hydroxy-4-methylpyridine, with its diverse chemical properties, plays a pivotal role in many fields such as medicine, materials, and chemical industry, and contributes greatly to the development and progress of various fields.

3-Hydroxy-4-methylpyridine is an organic compound. Its physical properties are as follows:
Its appearance is often white to light yellow crystalline powder. This substance is stable at room temperature and pressure, but it needs to pay attention to storage conditions to prevent deterioration.
Melting point is about 148-152 ° C. Melting point is the key physical characteristic of the substance, whereby its purity can be preliminarily determined. If impurities are mixed, the melting point may be deviated.
In terms of solubility, 3-hydroxy-4-methylpyridine is soluble in polar solvents such as water, ethanol, and acetone. This solubility is due to the presence of hydroxyl groups and pyridine rings in its molecular structure. Hydroxyl groups are hydrophilic, and pyridine rings can also interact with polar solvents, so they exhibit good solubility in the above solvents. This property is of great significance in the fields of organic synthesis, drug research and development, because it is related to the dispersion of the substance in the reaction system and the ability to participate in the reaction.
In terms of odor and taste, there is usually no special strong odor, and the taste may have a slight bitter feeling, but such sensory properties are not easy to describe accurately, and there are differences in individual perception.
In addition, the density of the substance is about 1.23 g/cm ³, and the density is the mass of the substance per unit volume, which is of great significance for its measurement and operation in practical applications. For example, when formulating a solution or performing a reaction, knowing the density helps to accurately measure the substance and ensure the accuracy of the experiment or production process.

The stability of the chemical properties of 3-hydroxy-4-methylpyridine depends on multiple factors.
In terms of its structure, the pyridine ring is aromatic, and this aromatic system gives it a certain stability. The nitrogen atom in the ring has lone pairs of electrons, which participate in the conjugation system, so that the electron cloud distribution is more uniform and enhances the stability of the structure. The substitution of hydroxyl groups with methyl groups also affects its stability. The presence of
hydroxyl groups can increase the electron cloud density on the pyridine ring because of its electron-giving conjugation effect. Although the electron cloud distribution of the ring is changed to a certain extent, the stability of the ring is also affected by the possibility of forming intramolecular or intermolecular hydrogen bonds. If intramolecular hydrogen bonds are formed, the stability of the molecule can be enhanced; however, if too many intermolecular hydrogen bonds are formed, or under specific circumstances, the stability of its chemical properties may also be affected.
As for methyl, it is a donator group, which can increase the electron cloud density of the adjacent and para-position of the pyridine ring, which affects the activity of electrophilic substitution reactions. However, the donator effect of methyl helps to stabilize the positive ion intermediates of the pyridine ring to a certain extent, and shows a positive effect on stability in some reactions.
However, the stability of chemical substances is not a single matter, but depends on the environment. In an acid-base environment, 3-hydroxy-4-methylpyridine may react due to the acidity of the hydroxyl group or the alkalinity of the nitrogen atom, which affects its stability. In a redox environment, its hydroxyl group may be oxidized, and the pyridine ring may also participate in the redox reaction, changing its structure and stability.
Overall, the chemical stability of 3-hydroxy-4-methylpyridine is not absolute. It is not only affected by the interaction of various groups in its own structure, but also closely related to the external environment. Its stability varies under different conditions, and it needs to be analyzed in specific situations.

To prepare 3-hydroxy-4-methylpyridine, there are various methods.
First, it can be obtained from the oxidation and hydrolysis of 2-methyl-5-ethylpyridine. First, the side chain of 2-methyl-5-ethylpyridine is oxidized with an appropriate oxidant, such as potassium tamponate, etc., to obtain the corresponding carboxylic acid derivative. After hydrolysis, the carboxyl group can be converted into a hydroxyl group to obtain 3-hydroxy-4-methylpyridine. This way, attention should be paid to the conditions of the oxidation reaction, so as not to damage the pyridine ring, and the hydrolysis step needs to be precisely controlled to ensure that the reaction is complete. < Br >
Second, it can be prepared by nucleophilic substitution reaction of suitable pyridine derivatives. Choose a pyridine derivative containing an appropriate leaving group, such as halogenated pyridine, attack with a nucleophilic reagent, leave the leaving group, and introduce hydroxyl and methyl groups. However, the choice of nucleophilic reagents, reaction solvents and temperatures all have a great impact on the reaction. Careful selection of nucleophilic reagents is required to ensure that they are selective to halogenated pyridine attack, and at the same time, the reaction temperature and solvent should be optimized to improve the efficiency and yield of the reaction.
Third, a multi-step organic synthesis strategy can be used to gradually construct pyridine rings from simple starting materials, and hydroxyl and methyl groups can be introduced at the same time. For example, an appropriate nitrogenous compound and a carbonyl compound are used as the starting materials, and a pyridine ring is formed through condensation, cyclization, etc., and then a hydroxyl group and a methyl group are added after subsequent functional group conversion. Although this approach is complicated, the choice of starting materials is large, and the synthesis route can be flexibly adjusted according to actual needs and raw material availability. During the synthesis process, the intermediates in each step of the reaction need to be carefully separated and identified to ensure that the reaction proceeds in the desired direction, and finally a pure 3-hydroxy-4-methylpyridine is obtained.

Today there are 3-hydroxy-4-methylpyridine, the price on the market, its range is difficult to determine. The price of the cover often changes due to many reasons, such as the abundance of production, the amount of demand, and the difficulty of making it.
If the product is prosperous, the market is abundant, and the supply exceeds the demand, the price may decrease. On the contrary, if the product is thin, the demand is numerous, and the supply is in short supply, the price will increase. And the difficulty of making this product also affects its price. If it is easy to make, the cost will decrease, and the price will also decrease; if it is difficult to make, the cost will be high, and the price will also increase.
Furthermore, the wide and narrow use of it will also affect its price. If it is used widely in the pharmaceutical and chemical industries, there will be many applicants and the price will be high; if it is used narrowly, there will be few applicants and the price will be low.
With common sense, the price per gram may be between tens of yuan and hundreds of yuan. However, this is only an approximate number, and it is not an exact value. The market conditions are ever-changing. If you want to know the exact price, you must carefully observe the current market conditions and consult vendors and businesses before you can get it.