3-Cyano-2-hydroxypyridine

3-Cyano-2-hydroxypyridine, this substance has a wide range of uses. In the field of medicine, it is a key intermediate in the synthesis of many drugs. Due to its special chemical structure, it can participate in a variety of reactions and help build complex drug molecular structures, playing an important role in the creation of antibacterial, anti-inflammatory and anti-tumor drugs.
In the field of materials science, it can be used to prepare functional materials. For example, through specific chemical reactions, it can be combined with other compounds to give materials unique optical, electrical or adsorption properties, such as in organic Light Emitting Diode (OLED) materials to improve luminous efficiency and stability; or in the preparation of adsorption materials, which exhibit high selective adsorption ability for specific substances. < Br >
also has its uses in agricultural chemistry. It can be used as a raw material to synthesize new pesticides. With its structural characteristics, it endows pesticides with good biological activity and environmental compatibility, efficient control of pests and diseases, and less harm to the environment.
In the field of organic synthetic chemistry, it is an important kind of building block. With the reactivity of cyano and hydroxyl groups, it can carry out various reactions such as nucleophilic substitution and cyclization, providing an effective path for the synthesis of organic compounds with specific structures and functions, and promoting the development of organic synthetic chemistry.

The synthesis method of 3-cyano-2-hydroxypyridine has been known for a long time, and it is also often studied by organic synthesis chemists today. Today, I will describe the various synthesis paths.
First, pyridine derivatives are used as starting materials. You can first take an appropriate pyridine and introduce cyano and hydroxyl groups at specific positions in the pyridine ring. To introduce cyano groups, cyanide-containing reagents, such as potassium cyanide, sodium cyanide, etc., are often used under suitable reaction conditions, through reactions such as nucleophilic substitution, so that cyano groups are attached to the pyridine ring. As for the introduction of hydroxyl groups, halogenated pyridine can be used to react with nucleophilic reagents. Nucleophilic reagents containing hydroxyl groups or those that can be converted into hydroxyl groups, such as alkoxides, etc., are substituted by nucleophilic substitution to obtain hydroxyl-containing pyridine derivatives. After ingeniously designing the reaction sequence and conditions, 3-cyano-2-hydroxypyridine can be prepared.
Second, synthesized by the heterocyclic construction method. Using small molecules containing nitrogen and carbon as raw materials, pyridine rings are constructed through multi-step reactions. For example, small molecules containing cyanide groups and compounds containing functional groups such as carbonyl groups and amino groups, under acidic or basic conditions, through a series of reactions such as condensation and cyclization, pyridine rings are constructed. In the reaction, the reaction conditions are precisely regulated, so that the cyano group and the hydroxyl group are formed at the 3rd and 2nd positions of the pyridine ring, and then the target product 3-cyano-2-hydroxypyridine is obtained.
Third, the reaction is catalyzed by transition metals. Suitable pyridine derivatives are used as substrates, transition metals such as palladium and copper are used as catalysts, and ligands are synergistically catalyzed. In the presence of cyanide-containing sources and hydroxylating reagents, cyanide and hydroxyl groups are precisely introduced into the pyridine ring through catalytic coupling reaction. This method has good selectivity and milder reaction conditions, which can effectively synthesize 3-cyano-2-hydroxypyridine.
All synthetic methods have their own advantages and disadvantages, and must be selected according to actual demand, raw material availability, cost and other factors in order to efficiently synthesize 3-cyano-2-hydroxypyridine.

3-Cyano-2-hydroxypyridine is one of the organic compounds. Its physical properties are quite unique, with specific properties such as melting point, boiling point and solubility.
Looking at its properties, under normal temperature, it is mostly in a solid state, but the specific form may vary depending on the purity and preparation method, or it is crystalline or powdery.
In terms of its melting point, the melting point of this substance is often a key indicator for measuring its purity and characteristics. It has been determined by many experiments that it is about a specific temperature range, which varies slightly due to the measurement environment and the precision of the instrument. The exact value of the melting point is an important parameter in chemical production and scientific research experiments, and it is related to the process of separation, purification and application.
The boiling point is also one of its important physical properties. When the external pressure reaches standard atmospheric pressure, 3-cyano-2-hydroxypyridine will boil and vaporize at a specific temperature. This boiling point value is crucial in the separation process of distillation and rectification, which can help chemists to accurately separate it from the mixture.
In terms of solubility, 3-cyano-2-hydroxypyridine behaves differently in different solvents. In organic solvents such as ethanol and acetone, its solubility is good, and it can form a uniform solution with solvents. However, in water, its solubility is relatively low. The difference in solubility is due to the difference in its molecular structure and the intermolecular forces of the solvent. The molecular structure of organic solvents is more compatible with 3-cyano-2-hydroxypyridine, and the intermolecular interactions such as hydrogen bonds and van der Waals forces can be formed, so it can be dissolved. The molecular polarity and structural characteristics of water result in weak intermolecular forces with 3-cyano-2-hydroxypyridine and limited solubility.
In conclusion, the physical properties of 3-cyano-2-hydroxypyridine are of great significance in many fields such as organic synthesis, drug development, materials science, etc., laying the foundation for its rational application and in-depth research.

3-Cyano-2-hydroxypyridine, this is an organic compound with unique chemical properties. In its structure, cyano and hydroxyl coexist in the pyridine ring, resulting in complex and diverse properties.
First of all, its acidity and alkalinity, due to the presence of hydroxyl groups, can weakly ionize hydrogen ions, show weak acidity, and can neutralize with bases, such as sodium hydroxide, or generate corresponding salts and water. However, the nitrogen atom of the pyridine ring has lone pairs of electrons, which makes it slightly alkaline and can form salts with strong acids. In the case of hydrochloric acid, it can form hydrochloride salts.
In addition to its nucleophilic reactivity, the cyano group is a strong electron-absorbing group, which reduces the electron cloud density of the pyridine ring, especially the density of the ortho and para-position electron clouds, which makes it a nucleophilic reagent attack check point. If there are nucleophilic reagents such as sodium alcohol, or under specific conditions, the nucleophilic substitution of the pyridine ring generates new derivatives.
Cyanyl groups also have characteristics, which can be hydrolyzed and converted into carboxylic groups. Under the catalysis of acids or bases, they undergo a series of reactions and finally form carboxylic acids. And cyano groups can be reduced, and under the action of suitable reducing agents, such as lithium aluminum hydride, they can be changed into amino groups, and new compounds containing amino groups can be derived
Its hydroxyl groups can also participate in the reaction and can be replaced by halogen atoms. For example, when reacting with halogenating agents, the hydroxyl groups are replaced by halogen atoms for the synthesis of halogen-containing derivatives, which is an important conversion step in organic synthesis. At the same time, the hydroxyl groups can be esterified with acids to form ester compounds, which is a common method for preparing ester products.
In short, 3-cyano-2-hydroxypyridine has rich chemical properties and can be used in the field of organic synthesis. With the characteristics of each group, it can construct organic compounds with diverse structures and has a wide range of applications.

My question today is to ask about the price of 3-cyano-2-hydroxypyridine in the market. This substance may involve chemical, pharmaceutical and other fields, but its price varies from time to time, and it also varies according to quality, quantity and source.
I heard that "Tiangong Kaiwu" said: "The price of all things in the world is uncertain, and it changes with supply and demand and technology." The same is true for 3-cyano-2-hydroxypyridine. If you want to know its exact price, when observing the chemical market conditions, consult the suppliers.
In the past, the market conditions may be different. In the past, due to the complex process, the output of this substance was not abundant, and the price was high. After the technology is refined, the output gradually increases, and the price may drop slightly. However, due to changes in raw material prices, policies and regulations, the price also fluctuates.
If you want to get the exact price at the moment, you can find it on the chemical trading platform, or visit the chemical raw material supplier in person. They often know the latest market conditions and can give a detailed price. You must not just rely on the price of the past and today's market. You need to know that the market is fickle, and you should pay attention in real time to get an accurate number.