3-Cyano-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine

3-Cyano-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine is an important compound in the field of organic synthesis. Its main uses involve a wide range of medical drugs, pesticides and many other aspects.
In the field of medicine, this compound is often used as a key intermediate to create new drugs. Due to its unique chemical structure, it can interact with specific targets in organisms, thus exhibiting significant biological activity. For example, enzymes or receptors related to specific diseases can produce inhibitory or activating effects, providing a crucial basis for the development of specific drugs for difficult diseases such as cancer and neurological diseases. Studies have shown that reasonable structural modification and optimization can effectively improve its pharmacological activity and selectivity, reduce toxic and side effects, and greatly enhance the efficacy and safety of drugs.
In the field of pesticides, 3-cyano-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine also plays an indispensable role. Because of its certain biological activity, it can be used to develop high-efficiency, low-toxicity and environmentally friendly pesticide products. It can target common diseases and insect pests of crops, such as the resistance of pests, and integrate this compound into pesticide formulations through precise molecular design to improve the killing effect of pesticides on pests, and reduce the adverse effects on beneficial organisms and the environment. It effectively protects the healthy growth of crops and contributes to the sustainable development of agriculture.
In summary, 3-cyano-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine has broad application prospects in the field of medicine and pesticides with its unique structure and significant biological activity, which is of great significance for promoting the progress of related industries.

The synthesis of 3-cyano-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine has many paths to follow.
First, fluorobenzaldehyde and specific pyridine derivatives are used as starting materials. First, fluorobenzaldehyde and pyridine derivatives undergo a condensation reaction under alkali catalysis to form key intermediates. This condensation reaction requires fine regulation of the reaction temperature and the amount of base. Too high or too low temperature, too much or too little alkali may affect the reaction process and product purity. Then, the intermediate is cyanized under the action of cyanide reagents, and the target product is obtained. In this process, the selection of cyanide reagents and the optimization of reaction conditions are very important. The activities of different cyanide reagents are different, and the reaction conditions need to be adjusted accordingly.
Second, based on the parent structure of pyrazolo [3,4-b] pyridine. First, the parent structure is benzylated, and a suitable benzylating reagent and catalyst are selected to react in a suitable solvent. The activity of the benzylating reagent, the type and dosage of the catalyst, and the polarity of the solvent will all affect the reaction effect. Subsequently, the cyanide group is introduced into the benzylated product, which can be achieved by reacting with cyanizing agents such as potassium cyanide under specific conditions. This step requires strict reaction environment, and factors such as moisture and temperature need to be precisely controlled.
Third, we can also try to construct a strategy of pyrazolo [3,4-b] pyridine ring. Using compounds containing cyanyl and benzyl related structures as raw materials, in a suitable reaction system, the intracellular cyclization reaction occurs to construct the target pyridine ring structure. This path requires careful design of the reaction substrate structure and strict control of the cyclization reaction conditions such as reaction time, temperature, catalyst, etc., in order to improve the yield and purity of the product.
The above methods have advantages and disadvantages. In actual synthesis, it is necessary to comprehensively weigh the availability of raw materials, reaction costs, product purity requirements and many other factors to choose the best synthesis path.

The physicochemical properties of 3-cyano-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine are crucial and relate to the field of many applications.
In terms of physical properties, its appearance often takes a specific form, or is crystalline, with a unique color, but this color varies depending on the preparation and purity, or is white to off-white. Its melting point is an important indicator. After accurate determination, it is about a certain temperature range, which is of great significance for its identification and purity determination. And in common organic solvents, solubility is also one of the characteristics. In some organic solvents such as ethanol and dichloromethane, it exhibits different degrees of solubility, either easily soluble or slightly soluble. This property has far-reaching impact on its application in synthesis and preparation processes.
When it comes to chemical properties, it contains cyanide groups and has high reactivity. It can participate in a variety of chemical reactions, such as nucleophilic substitution reactions. Cyanyl groups can react with nucleophiles to derive various new compounds. At the same time, the structure of pyrazolopyridine gives it unique electronic properties, enabling it to coordinate with metal ions, which has potential applications in catalysis and materials science. In addition, the fluorine atom in the 2-fluorobenzyl part, due to its high electronegativity, affects the distribution of molecular electron clouds, which in turn affects the chemical stability and reactivity of the whole molecule. In pharmaceutical chemistry, it can affect its interaction with biological targets, which is of great significance for the development of new drugs.

I don't know if 3 - Cyano - 1 - (2 - fluorobenzyl) - 1H - pyrazolo [3,4 - b] pyridine is in the market price range. This compound is relatively rare and is very common in commercially available general-purpose chemicals. Its price is determined by many factors, such as ease of preparation, market demand, purity requirements, etc.
If the preparation is difficult, complex steps, special raw materials or harsh conditions are required, the cost must be high, and the price is also expensive. Like some compounds containing rare elements, requiring chiral synthesis or multi-step reaction and low yield, the price is often high.
Market demand is also critical. If the demand is large, the manufacturer may increase production, the cost may be reduced due to scale effect, and the price may be relatively close to the people; if the demand is small, only a few scientific research institutions or enterprises need it, the output is low, and the price may be high.
Purity requirements also have a great impact on the price. High-purity products require finer purification processes, and the cost increases, so the price is naturally higher. For high-purity compounds used in drug research and development, the price far exceeds that of general industrial-grade purity products.
For the exact price range, you can consult professional chemical reagent suppliers, such as Sigma-Aldrich, Alfa Aesar, etc., or search on the chemical product trading platform, or contact relevant manufacturers for consultation. However, due to dynamic changes in information, the actual price is subject to real-time consultation.

3-Cyano-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine is a very important organic compound, which has shown potential application value in many fields such as medicinal chemistry and materials science. The number of related patents surrounding this compound is considerable, and the key one is selected to be described in ancient and elegant words.
In the field of pharmaceutical research and development, there are patents focusing on the application of this compound as an active ingredient in new drugs. This patent reveals that 3-cyano-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine has significant affinity and inhibitory activity against specific disease-related targets. For example, targeting certain inflammation-related cell signaling pathways, this compound can precisely act and effectively regulate the activity of key proteins in the pathway, thus providing new strategies and drug options for the treatment of inflammatory diseases.
Another patent relates to the synthesis method of this compound. This synthetic patent carefully designs an efficient and environmentally friendly synthetic route, and greatly enhances the yield and purity of the compound through clever selection of starting materials and reaction conditions. The reaction steps used are concise and clear, avoiding many cumbersome processes and the generation of harmful by-products in traditional synthesis methods, which is a model application of the concept of green chemistry in the synthesis of this compound.
Furthermore, in the field of materials science, there is a patent to explore its use in the preparation of functional materials. By appropriate chemical modification and structural regulation of the compound, it can be introduced into the polymer material system to endow the material with unique optical and electrical properties. Such as the preparation of organic Light Emitting Diode materials with specific luminescence properties, or functional materials for high-performance battery electrode modification, these are all innovative applications of the compound in the field of materials, opening up broad prospects for the research and development of new materials.
In summary, the patents related to 3-cyano-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine cover a wide range of fields such as medicine and materials, laying a solid foundation for its further research and application, and injecting new vitality into the development of related industries.