3-Chloropyridine-2-carboxylic acid

3-Alkane-2-carboxylic acid is mainly used in many fields. In the field of organic synthesis, this is a key intermediate. Because of its specific chemical activity and structural properties, it can be derived through a variety of chemical reactions. Many valuable organic compounds.
Such as the process field involved in "Tiangong Kaiji", it may be used for the preparation and transformation of certain substances. In the fine chemical industry, 3-alkane-2-carboxylic acid can be used as a starting material for the synthesis of materials with special properties. For example, the synthesis of polymer materials with unique solubility, stability or reactivity can achieve precise regulation of material properties through the modification and transformation of their structures.
In the field of medicinal chemistry, it also plays an indispensable role. The construction of many drug molecules requires this as the basic structural unit. Because it can participate in various bonding reactions, build a complex drug molecular skeleton, and then endow drugs with specific pharmacological activities. By carefully designing the reaction route, using the chemical properties of 3-alkane to its -2-carboxylic acid, drugs can be synthesized for specific disease targets, providing support for human health.
In addition, in the fragrance industry, it can be used as a raw material for synthesizing fragrances. Due to its special chemical structure, the products generated after reaction or have unique aromas, which can enrich the variety of fragrances and meet the diverse needs of different consumers for aroma. In conclusion, 3-alkane-2-carboxylic acids have been widely used in many fields such as organic synthesis, fine chemical industry, medicinal chemistry and fragrance industry due to their unique chemical properties.

The outer layer is white to off-white powder or powder, which has a faint special smell. The phase density is special, and the solid density is 1.074g/cm ³. This density characteristic makes it show a specific distribution in the polychemical system.
The boride fusion is around 400 ° C. It may react due to factors such as water vapor in the contact air before it arrives. It is fixed in the dry air and can be stored in the dry air. However, in the tidal air, it is susceptible to deliquescence and gradually fails.
In terms of solubility, the boride is easily soluble in water, and the dissolution is accompanied by the reaction of the reaction, and the reaction of the water is released. The intensity of the reaction is affected by factors such as the degree of reaction. The higher the degree of reaction, the more intense the reaction. In alcoholic solutions, such as methanol and ethanol, boron oxide also has a certain solubility, and the reaction activity in alcoholic solutions is different in water. It is often used for specific synthetic reaction parts.
In addition, boron oxide powders or particles can form explosive mixtures in the air. In case of open flame or high flammable explosion, the characteristics of boron oxide make it necessary to pay special attention to fire and explosion-proof measures during storage, combustion and use to ensure operational safety.

3-Hydroxybutyric acid, its chemical properties are quite stable.
3-Hydroxybutyric acid, also known as β-Hydroxybutyric acid, plays an important role in the metabolic process of the human body under normal physiological conditions. Under certain circumstances, such as long-term fasting and strenuous exercise, the human body produces 3-Hydroxybutyric acid as a source of energy supply.
From a chemical structure point of view, 3-Hydroxybutyric acid contains one hydroxyl group and one carboxyl group. The functional group of the hydroxyl group gives it a certain hydrophilicity, enabling it to have a certain solubility in water. The carboxyl group gives 3-Hydroxybutyric acid an acidic character, and can undergo acid-base neutralization under suitable conditions.
In terms of its stability, 3-hydroxybutyric acid can maintain a relatively stable state under normal temperature and environmental conditions. However, if the ambient temperature is too high, or if it comes into contact with certain chemical reagents, it will also undergo chemical reactions. For example, under the action of strong oxidizing agents, the hydroxyl group may be oxidized, causing its chemical structure to change. Or in the presence of acidic or basic catalysts, the carboxyl group may participate in reactions such as esterification.
However, in conventional storage and use environments, as long as extreme conditions and highly active chemicals are avoided, 3-hydroxybutyric acid can maintain relatively stable chemical properties and is not prone to spontaneous significant changes. Therefore, in general, 3-hydroxybutyric acid is chemically stable under common conditions.

There are several methods for the synthesis of 3-cyano-2-naphthalic acid.
First, 2-naphthalaldehyde is used as the starting material, and a cyanyl group can be introduced through cyanidation. In a suitable solvent, such as a mixture of ethanol and water, adding cyanidation reagents such as sodium cyanide or potassium cyanide, under certain temperature and catalytic conditions, the aldehyde group of 2-naphthalaldehyde can undergo nucleophilic addition reaction with the cyanyl group to form 2-cyano-2-naphthalene methanol intermediate. Subsequently, through the oxidation step, using an oxidizing agent such as potassium permanganate or potassium dichromate, under suitable pH and temperature conditions, the alcohol hydroxyl group of the intermediate can be oxidized to a carboxyl group to obtain 3-cyano-2-naphthalic acid.
Second, 2-naphthalene acetonitrile is used as the starting material. First, the naphthalene ring is subjected to a positioning substitution reaction. Taking advantage of the difference in electron cloud density at a specific position of the naphthalene ring, through an electrophilic substitution reaction, in the presence of a suitable catalyst such as aluminum trichloride, and a suitable halogenated reagent, such as a chlorinated reagent or a brominated reagent, the halogen atom replaces the hydrogen atom at a specific position on the naphthalene ring. Next, through the reaction of cy After that, one of the cyanyl groups is hydrolyzed, and under acidic or basic conditions, it is converted to a carboxyl group, and then 3-cyano-2-naphthenic acid is synthesized.
Third, naphthalene is used as the starting material, through Fu-g acylation reaction, an acyl group is introduced on the naphthalene ring to generate 2-naphthalenone compounds. Then, the methyl group connected to the carbonyl group is converted to a carboxyl group by haloform reaction under basic conditions. Then, through cyanation reaction, a cyanyl group is introduced at a suitable position, and through a series of reaction conditions and optimization, the final synthesis of 3-cyano-2-naphthalenic acid is completed.
The above synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider many factors such as the availability of raw materials, the difficulty of controlling reaction conditions, and the purity requirements of the product to choose the most suitable synthesis path.

3-Bromopyridine-2-carboxylic acid is available in the market. As far as I know, its price varies depending on the product, supplier, and quantity.
Generally speaking, if a small amount of 3-bromopyridine-2-carboxylic acid is used in the room, and the cost of production is also increased.
If a large amount of labor is required, the cost can be reduced due to the high molding efficiency, and the cost can be reduced. The cost per kilogram may range from 100 to 1,000 yuan. However, this also depends on the supply and demand of the market. If the supply is greater than the demand, there may be a decline in the price; if the supply is not in demand, the price may be higher.
And the market of chemical raw materials is proliferating, and many factors such as the quality of raw materials, industrial reform, policy and law can all be affected by the quality of 3-bromopyridine-2-carboxylic acid. In order to know its quality, it is appropriate to contact the suppliers of chemical raw materials, or to examine the quality of recent market transactions.