3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Methyl 3-chloro-5- (trifluoromethyl) pyridine-2-carboxylate. This is an organic compound. It has unique chemical properties.
Looking at its structure, the presence of the pyridine ring endows the compound with certain aromaticity and stability. The chlorine atom is attached to the third position of the pyridine ring. Due to its electronegativity, it can affect the electron cloud distribution of the molecule and reduce the electron cloud density of the pyridine ring, thereby affecting the reactivity of the compound. In the electrophilic substitution reaction, the electron cloud density of the neighboring and para-position of the chlorine atom is relatively low, and the reaction tends to occur in the mesotope. < Br >
The 5-position trifluoromethyl group is a strong electron-withdrawing group due to the strong electronegativity of the fluorine atom. This group further reduces the electron cloud density of the pyridine ring and enhances the polarity of the molecule, which has a significant impact on the physical and chemical properties of the compound. For example, it can improve the lipid solubility of the compound, making it more soluble in organic solvents.
Its 2-position carboxylic acid methyl ester functional group has the typical properties of an ester. Under alkaline conditions, hydrolysis is prone to occur, resulting in the formation of corresponding carboxylate and methanol. Under acidic conditions, hydrolysis can also occur, but the reaction rate may be different from that under alkaline conditions. This ester group can also participate in reactions such as alcoholysis and aminolysis, and interact with alcohols, ammonia and other reagents to form new esters or amides.
In addition, this compound can be used as an important organic synthesis intermediate because it contains a variety of electronegative atoms and functional groups, which can be used to construct more complex organic molecular structures. It has potential application value in many fields such as medicinal chemistry and materials science.

Methyl 3-chloro-5- (trifluoromethyl) pyridine-2-carboxylate, this substance has a wide range of uses and is often used as a key intermediate in the field of pharmaceutical synthesis. The structural properties of the Gainpyridine ring and trifluoromethyl give it unique chemical and biological activities, which can participate in the construction of many drug molecules. For example, when developing antibacterial drugs, with its structural advantages, it can optimize the affinity and selectivity of the drug to specific bacterial targets, thereby enhancing the antibacterial efficacy.
In the creation of pesticides, it also plays an important role. It can be chemically modified to derive a series of pesticide active ingredients, or enhance the interference on the nervous system of pests, or affect the physiological and metabolic processes in the body, so as to achieve the purpose of efficient insecticidal and pest control, and the presence of trifluoromethyl may improve the environmental stability and shelf life of pesticides.
In the field of materials science, it is occasionally used. Due to its fluorine-containing structure, it may endow materials with special properties, such as introducing it into polymer materials, or improving the chemical resistance and weather resistance of materials, making it suitable for the preparation of materials in extreme environments. In addition, in the field of organic synthetic chemistry, as a reaction substrate, it can participate in many organic reactions, such as nucleophilic substitution, coupling reactions, etc., providing an effective way to construct complex organic molecular structures and assisting in the synthesis of new organic functional materials and fine chemicals.

The preparation of 3-chloro-5- (trifluoromethyl) pyridine-2-carboxylic acid methyl ester is very complicated, and it needs to follow the conventional route of organic synthesis and related chemical principles.
The first step is often to use suitable pyridine derivatives as starting materials. A pyridine compound with a suitable substituent can be found, and this substituent can be converted into the target 3-chloro, 5- (trifluoromethyl) and 2-carboxylic acid methyl ester groups through a series of reactions.
For the introduction of 3-chlorine atoms, chlorination can be selected. Depending on the activity and reaction conditions of the raw material pyridine derivatives, select suitable chlorination reagents, such as thionyl chloride, phosphorus oxychloride, etc. In appropriate solvents, such as dichloromethane, chloroform, etc., at a specific temperature and in the presence of a catalyst, the raw materials and chlorination reagents are fully reacted to promote the precise substitution of chlorine atoms in the third position of the pyridine ring.
As for the introduction of 5- (trifluoromethyl) groups, the common method is to use reagents containing trifluoromethyl. Such as trifluoromethylation reagents, such as sodium trifluoromethylsulfonate, etc. Under the action of bases and phase transfer catalysts, it reacts with pyridine derivatives to connect trifluoromethyl to the fifth position of the pyrid This process requires fine regulation of reaction conditions, such as temperature, amount of base, and reaction time, to ensure reaction selectivity and yield.
After the successful introduction of 3-chlorine and 5- (trifluoromethyl) on the pyridine ring, the 2-carboxylate methyl ester group is prepared. First, the 2-position of pyridine is converted into a carboxylated functional group, such as halogenation, by a suitable method. Afterwards, through carboxylation reaction, pyridine-2-carboxylic acid is formed in a specific reaction system with carbon dioxide as the carboxyl group source under the action of suitable metal catalysts and ligands. Finally, the carboxylic acid and methanol are esterified under acid catalysis. Concentrated sulfuric acid or p-toluenesulfonic acid are often used as catalysts. Under the condition of heating and reflux, 3-chloro-5- (trifluoromethyl) pyridine-2-carboxylic acid methyl ester can be obtained. After each step of the reaction, the product needs to be purified by suitable separation and purification means, such as column chromatography, recrystallization, etc., to ensure the smooth progress of subsequent reactions and the purity of the final product.

Methyl 3-chloro-5- (trifluoromethyl) pyridine-2-carboxylate is an important compound in organic chemistry. When storing and transporting, there are many key points to be paid attention to.
Bear the brunt, storage temperature is crucial. It should be placed in a cool place, away from high temperature and open flames, to avoid damage to the stability of the compound due to excessive temperature, and even the risk of fire or explosion. Because high temperature can easily cause the compound to chemically react and cause it to deteriorate, it cannot meet the needs of subsequent use.
Furthermore, humidity is also a factor that cannot be ignored. Be sure to keep the storage environment dry to prevent the intrusion of water vapor. Because the compound may react with water, causing adverse phenomena such as hydrolysis, affecting its quality and performance. Therefore, consider using a well-sealed container and placing a desiccant in the container to maintain a dry internal environment.
Regarding packaging, appropriate materials must be selected. The packaging used should have good corrosion resistance to prevent compounds from eroding the packaging and causing leakage. At the same time, the packaging should be sturdy and durable, and can resist a certain degree of collision and extrusion during transportation to ensure the safety of the compound.
During transportation, relevant regulations and standards must be strictly followed. Avoid mixing with oxidizing substances, alkaline substances, etc., as it may have violent chemical reactions with these substances. And transportation vehicles should be equipped with necessary emergency treatment equipment in case of leakage and other accidents, and can take timely and effective measures to deal with it.
In short, for the storage and transportation of 3-chloro-5- (trifluoromethyl) pyridine-2-carboxylic acid methyl ester, it is necessary to take care of many aspects such as temperature, humidity, packaging and transportation compatibility to ensure the quality and safety of the compound.

What you are inquiring about is the market price of methyl 3-chloro-5- (trifluoromethyl) pyridine-2-carboxylate. However, the market price of this product often varies due to factors such as time, place, quality and supply and demand, and it is difficult to know with certainty.
In the past, in the place where chemical materials were traded, the price of such fine chemicals changed, or it was due to the abundance of raw materials and the difficulty of process. If the raw materials are abundant and the process is refined, the cost may drop, and the price will be stable and low. On the contrary, if the raw materials are scarce and the process is complicated, the price will rise.
As far as the current market situation is concerned, it is difficult to explain the specific price without knowing the exact market situation. However, if you want to know more about it, you can visit the chemical product trading platform and professional chemical information agency. There are often general market conditions gathered there, and more accurate prices can be provided. Or contact the manufacturer or distributor, and you can also get real-time price news. The price may range from tens to hundreds of yuan per kilogram, depending on various circumstances.