3-chloro-5-(trifluoromethyl)pyridine-2-amine

3-Chloro-5- (trifluoromethyl) pyridine-2-amine, this substance has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry.
From the perspective of pharmaceutical creation, it can contribute to the synthesis of novel and specific therapeutic drug molecules. Due to its pyridine structure and unique substitution of chlorine and trifluoromethyl, compounds are endowed with different physical and chemical properties, which can play an important role in the interaction between drugs and biological targets. It can either adjust the lipophilicity and polarity of drugs, or affect the affinity and specificity of their binding to receptors, thereby helping to develop highly effective drugs for specific diseases, such as cancer and inflammatory diseases.
In the field of pesticide chemistry, it also has significant value. It can be used as a raw material to prepare pesticides with high insecticidal, bactericidal or herbicidal effects. Due to its structural characteristics, it may exhibit highly selective biological activity against specific pests, bacteria or weeds, while taking into account environmental friendliness, reducing adverse effects on non-target organisms, and contributing to the sustainable development of modern agriculture.
Furthermore, in the field of materials science, although it is not as widely used as the former two, its unique chemical structure may provide opportunities for the design and synthesis of new materials with special photoelectric properties, thermal stability or mechanical properties, such as for the research and development of organic semiconductor materials, opening up new paths for progress in this field.

The synthesis of 3-chloro-5- (trifluoromethyl) pyridine-2-amine is an important topic in the field of organic synthetic chemistry. There are various synthetic routes, and each has its own advantages and disadvantages. It should be carefully selected according to actual needs and conditions.
First, it can be obtained by the reduction reaction of 3-chloro-5- (trifluoromethyl) pyridine-2-nitrile. In this process, a suitable reducing agent, such as lithium aluminum hydride (LiAlH) or sodium borohydride (NaBH), is often used to promote the conversion of nitrile groups to amine groups under suitable reaction conditions. For example, 3-chloro-5- (trifluoromethyl) pyridine-2-nitrile is dissolved in an anhydrous organic solvent such as tetrahydrofuran (THF), lithium aluminum hydride is slowly added at low temperature, and then heated and refluxed. After careful treatment, such as extraction, washing, drying, column chromatography separation, etc., the target product can be obtained.
Second, it is also a common method to carry out nucleophilic substitution reaction with 3-chloro-5- (trifluoromethyl) pyridine-2-halide with ammonia source. The halide can be iodide, bromide or chloride, and the ammonia source can be ammonia, ammonia water or organic amine. If 3-chloro-5- (trifluoromethyl) pyridine-2-bromide is taken as an example, in the presence of an appropriate base, such as potassium carbonate (K 2O CO 🥰), and excess ammonia in an autoclave, react at a certain temperature and pressure. After the reaction, 3-chloro-5- (trifluoromethyl) pyridine-2-amine can also be obtained by conventional separation means.
Third, the coupling reaction catalyzed by transition metals can also be feasible. For example, suitable pyridine derivatives are used as substrates and reagents containing amine groups are catalyzed by transition metal catalysts such as palladium catalysts (such as Pd (PPh)) in ligands, bases and suitable solvents. Such methods have relatively mild conditions and high selectivity, but the catalyst cost is high, and the post-processing may be more complicated.
When synthesizing 3-chloro-5- (trifluoromethyl) pyridine-2-amine, the availability of raw materials, cost, difficulty of reaction conditions, yield and purity requirements should be considered comprehensively, and the best synthesis method should be carefully selected to achieve the goal of efficient, economical and environmentally friendly synthesis.

3-Chloro-5- (trifluoromethyl) pyridine-2-amine is a kind of organic compound. Its physical properties are particularly important, and it is related to its performance in various chemical processes and practical applications.
First, its appearance is mentioned. Under normal circumstances, this compound is mostly white to light yellow crystalline powder. This form is easy to store and transport, and it is easy to handle in most experimental operations. Its powder has a fine texture and a relatively uniform particle size distribution, which is conducive to rapid dispersion in various solvents or reaction systems, and then participates in chemical reactions.
As for the melting point, it is about a specific temperature range. This temperature value is a key indicator for identification and purity determination. Accurate determination of the melting point can help chemists determine the purity of the compound. If there are few impurities, the melting point approaches the theoretical value; if there are many impurities, the melting point will be shifted or the melting point range will be wider. The melting point of this compound is roughly around [X] ° C, which has been verified by many studies and production practices.
Solubility is also an important physical property. In organic solvents, such as common methanol, ethanol, dichloromethane, etc., 3-chloro-5- (trifluoromethyl) pyridine-2-amine exhibits a certain solubility. In methanol, it dissolves well after a little heating, forming a uniform solution. This property makes it easy to fully contact with other reagents in the solution system in organic synthesis and react. In water, its solubility is relatively poor, with only a very small amount of dissolution, which is determined by the ratio and distribution of polar and non-polar groups in the molecular structure of the compound.
Furthermore, the density of this compound also has its own characteristics. Although the exact density value will vary slightly due to measurement conditions, in general, its density is about [X] g/³ cm at room temperature and pressure. This density data is extremely important for the mass and volume conversion of this compound, and is indispensable for material measurement in chemical production, reactor loading, etc.
In addition, its vapor pressure also has corresponding values at specific temperatures. Vapor pressure reflects the tendency of the compound to change from solid or liquid to gaseous state. Lower vapor pressure indicates that at room temperature, its volatilization rate is relatively slow, which is conducive to reducing losses and safety risks caused by volatilization during storage and operation.
In summary, the physical properties of 3-chloro-5- (trifluoromethyl) pyridine-2-amine are related in terms of appearance, melting point, solubility, density and vapor pressure, which together affect their application and research in the field of chemistry.

3-Chloro-5- (trifluoromethyl) pyridine-2-amine, this is an organic compound with unique chemical properties. Its appearance may be white to pale yellow solid, and it is widely used in the field of organic synthesis.
On chemical activity, the presence of chlorine atoms and trifluoromethyl groups on the pyridine ring makes the compound have unique reactivity. Chlorine atoms can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, chlorine atoms may be replaced, thereby forming new carbon-heteroatomic bonds. This property makes this compound very useful in the fields of drug synthesis and materials science. It can introduce different functional groups through nucleophilic substitution reactions to synthesize target molecules with specific properties.
The presence of trifluoromethyl also significantly affects the properties of the compound. Trifluoromethyl has strong electron-absorbing properties, which can reduce the electron cloud density of the pyridine ring, making the pyridine ring more susceptible to attack by electrophilic reagents, and at the same time enhance the lipid solubility of the molecule. This property is of great significance for its biological activity and material properties. In drug development, lipid solubility enhances or helps the drug to pass through the biofilm and improve the bioavailability.
The amine group of this compound, as a nucleophilic group, can participate in a variety of reactions. For example, it reacts with acyl chloride or acid anhydride to form amide bonds. This reaction is often used in peptide synthesis and drug molecule modification. Amine groups can also undergo condensation reactions with aldodes or ketones to form imines or enamines, which can build complex molecular structures in organic synthesis.
In addition, the stability of 3-chloro-5- (trifluoromethyl) pyridine-2-amine is also worthy of attention. Although the pyridine ring confers certain stability, the presence of chlorine atoms and trifluoromethyl groups may affect its stability. Under specific conditions, such as high temperature, strong acid or strong base environment, the molecular structure may change, triggering decomposition or other side reactions. Therefore, when storing and using this compound, attention should be paid to the control conditions to ensure its stability and reaction selectivity.
To sum up, 3-chloro-5- (trifluoromethyl) pyridine-2-amine is rich in chemical properties and has broad application prospects in many fields such as organic synthesis, medicinal chemistry and materials science. Understanding and rationally utilizing its chemical properties will help to develop new compounds and materials and promote the development of related fields.

3-Chloro-5- (trifluoromethyl) pyridine-2-amine, the price of this product in the market is difficult to determine. Its price often changes due to many reasons, and the price of raw materials, the complexity of the production method, and the trend of supply and demand are all important factors.
Looking at the past examples, if the raw materials are abundant and easy to obtain, if the production method is simple and cost-effective, the price may be lower; on the contrary, if the raw materials are rare and complicated, and various expensive reagents and harsh conditions are required, the price will be higher.
In addition, the market supply and demand situation also affects its price. If there are many applicants, there are few suppliers, and the price will rise; if the supply exceeds the demand, the price will be in a downward state.
The merchants in the market also have their own prices, different sources, different quality or different, and the price is also different. And the amount of transactions is also related to the price. If you buy in bulk, you can often get a preferential price.
Therefore, if you want to know the exact price, you should carefully consider the market conditions and consult the merchants to obtain a more accurate price range. However, it is difficult to determine the exact number, covering the ever-changing market conditions, and the law of impermanence can be followed.