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What are the physical properties of 3-CHLORO-5-FORMYL-2-METHOXYPYRIDINE?
3-Chloro-5-formyl-2-methoxypyridine, this is an organic compound. Looking at its physical properties, it is mostly solid at room temperature. Key data such as its melting point and boiling point are difficult to determine for the time being due to lack of data.
However, in terms of solubility, the compound may have a certain solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). Due to the structural characteristics of organic matter, it can be dissolved with organic solvents through intermolecular forces such as van der Waals force and hydrogen bonding.
As for its appearance, or white to light yellow solid powder, this speculation is derived from many pyridine derivatives with similar structures, which often exhibit such appearance characteristics.
Furthermore, its density is also difficult to describe accurately due to the lack of accurate data. However, according to the general laws of organic compounds, the density may be similar to that of common organic solids. Its volatile properties, or due to the presence of chlorine atoms, formyl groups and methoxy groups in the molecular structure, make it less volatile. This is because these groups enhance the intermolecular forces, making it more difficult for molecules to escape from the solid surface.
In summary, although some physical properties are difficult to clarify due to insufficient data, the general principles of organic chemistry and the characteristics of similar compounds can be used to roughly infer the physical properties of 3-chloro-5-formyl-2-methoxypyridine.
3-CHLORO-5-FORMYL-2-METHOXYPYRIDINE chemical synthesis methods
There are many different ways to synthesize 3-chloro-5-formyl-2-methoxypyridine. One of the common ones is to use 2-methoxy-3-chloropyridine as the starting material and prepare it by mild formylation reaction. In this reaction, suitable formylation reagents can be selected, such as N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl). First, mix 2-methoxy-3-chloropyridine and DMF in a certain proportion. In a low temperature environment, slowly add POCl < unk >, add it dropwise, gradually heat up to a moderate temperature, and maintain the reaction for a period of time. After the reaction is completed, the target product can be obtained after proper post-processing, such as neutralization, extraction, column chromatography, etc.
Another route is to use the corresponding pyridine derivative as the substrate, first introduce the methoxy group, then introduce the chlorine atom at the appropriate position, and finally construct the formyl group through the appropriate reaction. In this route, when introducing the methoxy group, a strong base and a methoxy-containing reagent can be selected to react in a suitable solvent. When introducing the chlorine atom, a specific chlorination reagent and reaction conditions need to be selected according to the characteristics of the substrate. There are also various reaction options for the construction of the formyl group, such as variants of the Vilsmeier-Haack reaction, or other specific formylation methods. The reaction conditions of each step need to be carefully adjusted to achieve high yield and purity. The post-processing process should also be handled carefully to ensure the quality of the product.
What are the main uses of 3-CHLORO-5-FORMYL-2-METHOXYPYRIDINE?
3-Chloro-5-formyl-2-methoxypyridine is an important compound in the field of organic chemistry. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs. Due to its specific chemical structure, it can introduce other functional groups through various chemical reactions to construct molecular structures with specific pharmacological activities.
In the field of materials science, this compound also has its uses. Or can participate in the preparation of organic materials with special properties, such as luminescent materials, conductive materials, etc. Due to the chlorine, formyl and methoxy functional groups contained in its structure, it can have a significant impact on the electronic structure and physical properties of the material, which in turn endows the material with unique properties.
In addition, in the field of pesticide chemistry, 3-chloro-5-formyl-2-methoxypyridine also plays an important role. Or it can be used as a starting material for the synthesis of new pesticides. Through chemical modification, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be created to meet the needs of agricultural production for pest control.
Furthermore, in the study of organic synthetic chemistry, this compound is often used as a model substrate to explore novel reaction pathways and methods. Chemists can study the mechanisms and conditions of various chemical reactions based on their structural properties, thus promoting the development and progress of organic synthetic chemistry. In short, 3-chloro-5-formyl-2-methoxypyridine has shown important application value in many fields, providing a key material basis for the development and practical application of related disciplines.
3-CHLORO-5-FORMYL-2-METHOXYPYRIDINE What are the precautions during storage?
3-Chloro-5-formyl-2-methoxypyridine is an important compound in organic synthesis. During storage, many matters must be paid attention to.
First, it is extremely sensitive to temperature. At high temperatures, this compound is prone to decomposition reactions, resulting in damage to its structure and quality and purity. Therefore, it should be stored in a cool place, usually at 2-8 ° C, so as to ensure the stability of its chemical properties.
Second, moisture is also a big enemy. Because of its specific chemical activity, it is easy to hydrolyze in contact with water, which in turn affects its chemical properties. Be sure to store in a dry place. A desiccant can be placed in the storage container to absorb possible water vapor.
In addition, light will also affect it. Long-term light exposure may cause luminescent chemical reactions to change its molecular structure. Therefore, when storing, use an opaque container or place it in a dark place.
Repeat, this compound may be toxic and irritating. The storage place should be well ventilated to prevent human contact and inhalation. When using, follow strict safety procedures and wear protective equipment such as gloves, goggles, etc.
In addition, the material of the storage container should not be underestimated. Materials with good compatibility should be selected to avoid chemical reactions and affect the quality of the compound.
In conclusion, to properly store 3-chloro-5-formyl-2-methoxypyridine, careful attention must be paid to various aspects such as temperature, humidity, light, ventilation, and container material to ensure its quality and stability.
What is the market price range for 3-CHLORO-5-FORMYL-2-METHOXYPYRIDINE?
3-Chloro-5-formyl-2-methoxypyridine, this product is in the market, its price is variable, and it varies for many reasons. The price of various chemical products in the past is related to the difficulty of preparation. If the preparation method is complicated and expensive, it needs rare raw materials, and after many difficult processes, its price will be high. If the preparation road is simple and easy, the raw materials are common and easy to obtain, and the price is low. Second, the trend of supply and demand also affects its price. If there are many people in the market, and the supply is small, the price will rise; if the supply exceeds the demand, the price may fall. Third, time and place are also the main reasons. Different seasons, different places of origin, the price varies. Either due to transportation costs, or due to local supply and demand conditions, the price can vary.
In the past, similar chemical products, difficult to prepare, can reach several gold or even tens of gold per gram; easy to prepare, per gram or only a few horns. As for 3-chloro-5-formyl-2-methoxypyridine, without the exact market conditions, it is difficult to determine its exact price. However, by common sense, if the preparation is quite difficult, the raw materials are rare, and it is worth asking for more and less, the price per gram may be between a few gold and more than ten gold; if the preparation is not difficult, the raw materials are easy to obtain and the supply is also sufficient, and the price per gram may be between a few cents and a few gold. This is all the number of degrees, and the actual price depends on the current market situation and various factors.