3-chloro-5-(difluoromethoxy)-Pyridine

3-Chloro-5- (difluoromethoxy) pyridine is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry. When it comes to pharmaceutical research and development, it can be used as a starting material to build molecules with complex structures and specific biological activities through multiple and delicate chemical reactions, thus paving the way for the creation of new drugs. For example, it can be used to synthesize drugs with therapeutic potential for specific diseases such as cardiovascular diseases and tumors.
In the field of pesticide chemistry, it also plays an important role. The pesticide components derived from it have a unique mechanism of action on pests, or interfere with the nervous system of pests, or destroy their physiological and metabolic processes, thus effectively preventing and controlling crop pests, helping agriculture to produce a bumper harvest, and ensuring the supply and quality of food.
Furthermore, in the field of materials science, this compound can endow materials with some excellent properties due to its special chemical structure. For example, new polymer materials involved in synthesis, or have good heat resistance, chemical stability, etc., have potential applications in high-end fields such as electronic devices and aerospace. From this perspective, 3-chloro-5- (difluoromethoxy) pyridine plays an indispensable role in many important fields, promoting the progress and development of technology in various fields.

3-Chloro-5- (difluoromethoxy) pyridine, an organic compound, is widely used in the field of organic synthesis. Its physical properties are related to many aspects, and I would like to describe them in detail.
Looking at its properties, it is mostly a colorless to pale yellow liquid under normal conditions. The appearance of this form is due to the characteristics of its molecular structure. The intermolecular force is moderate, which causes it to exist in this aggregated state under normal temperature and pressure.
As for the melting point, it has been determined by various experiments to be between -20 ° C and -15 ° C. This value indicates that the substance solidifies at a relatively low temperature. The level of this melting point is closely related to the size, shape and intermolecular forces of the molecule. In its molecular structure, the presence of chlorine atoms and difluoromethoxy groups affects the close arrangement of molecules, which in turn affects the melting point.
The value of the boiling point is between about 180 ° C and 185 ° C. The boiling point reflects the difficulty of changing a substance from a liquid state to a gas state. In this temperature range, the energy obtained by the molecule is sufficient to overcome the intermolecular forces and escape from the liquid surface to become a gaseous state. The boiling point value of 3-chloro-5 - (difluoromethoxy) pyridine shows that it has a certain volatility, but compared with some low-boiling compounds, the volatility is not very high. < Br >
In terms of solubility, this compound exhibits good solubility in common organic solvents such as ethanol, ether, dichloromethane, etc. This phenomenon is due to the interaction between its molecular structure and organic solvent molecules, such as van der Waals force, hydrogen bond, etc., so it can be miscible with each other. However, in water, its solubility is poor, because water is a highly polar solvent, and the molecular polarity of this compound is relatively weak. According to the principle of "similar miscibility", the two are difficult to miscible.
Density is also one of the important physical properties, and its density is about 1.35g/cm ³. This value represents the mass of the substance per unit volume, reflects the compactness of the molecular accumulation, and is related to the molecular structure and the type and quantity of constituent atoms.
In summary, the physical properties of 3-chloro-5- (difluoromethoxy) pyridine, such as its properties, melting point, boiling point, solubility, and density, are determined by its unique molecular structure, and these properties play a crucial role in its synthesis, separation, storage, and application.

To prepare 3-chloro-5- (difluoromethoxy) pyridine, there are three methods.
One is a halogenation reaction. Start with 5-hydroxy-3-chloropyridine to react with difluoromethyl halides in a base environment. Bases such as potassium carbonate are heated in a suitable solvent, such as N, N-dimethylformamide (DMF), and the hydroxyl group and difluoromethyl halides undergo nucleophilic substitution to obtain the target. The raw materials in this way are easy to find, but the preparation of 5-hydroxy-3-chloropyridine may require many twists and turns, and there may be side reactions in the reaction, which affect the yield and purity.
The second is the diazonium salt method. First, the diazonium salt is prepared from 3-amino-5-chloropyridine, and then it is reacted with the difluoromethoxy reagent. 3-amino-5-chloropyridine is combined with sodium nitrite and acid to form a diazonium salt, and then reacts with the reagent such as difluoromethoxy copper salt. After the diazonium group is replaced by the difluoromethoxy group, 3-chloro-5- (difluoromethoxy) pyridine is obtained. This diazonium salt is active and highly reactive, but the stability of the diazonium salt is poor, the operation needs to be cautious, and the reagent or toxicity used is high, which is not conducive to environmental protection.
The third is palladium-catalyzed cross-coupling. The reaction of 3-chloro-5-halogenated pyridine with difluoromethoxy borate or difluoromethoxy tin reagent is catalyzed by palladium catalyst. Palladium catalysts such as tetra (triphenylphosphine) palladium, ligand-assisted, alkali present, carried out in a suitable solvent. This method has good selectivity and mild conditions, but the palladium catalyst is expensive and the reaction cost is high, and the separation and recovery of the catalyst may be difficult.

3-Chloro-5- (difluoromethoxy) pyridine is one of the chemical substances. During storage and transportation, many important items need to be paid attention to.
When storing, choose the first environment. It should be placed in a cool, dry and well-ventilated place. This material is delicate, and it is easy to cause deterioration in a high temperature and humid environment. Therefore, the temperature of the warehouse must be strictly controlled to prevent it from being too high, and the humidity must be appropriate to prevent it from being hydrolyzed by moisture and damaging the quality.
Furthermore, the storage place should be isolated from oxidants, acids, bases and other substances. Gein 3-chloro-5- (difluoromethoxy) pyridine has special chemical activity, and it coexists with various chemicals, or reacts violently, causing the risk of fire and explosion.
The tightness of the packaging is also the key. The packaging material used must be corrosion-resistant and well sealed. To prevent leakage, not only to ensure that the substance itself is not affected by the outside world, but also to avoid it from causing harm to the surrounding environment and personnel.
As for transportation, the transportation vehicle should have protective facilities. The carriage must be clean and dry, and equipped with corresponding emergency treatment equipment. During loading and unloading, the operation must be cautious, light loading and light handling, and do not operate brutally to avoid packaging damage.
During transportation, always pay attention to weather changes. In case of severe weather, such as heavy rain and high temperature, proper protective measures need to be taken. At the same time, transportation route planning also needs to be careful, away from densely populated areas and important facilities, to prevent accidents and endanger public safety.
In short, every step of 3-chloro-5 - (difluoromethoxy) pyridine storage and transportation needs to be strictly followed and handled with caution to ensure safety.

What you are asking about is the market price of 3-chloro-5- (difluoromethoxy) Pyridine. However, the market price of this chemical is difficult to determine. The price of this chemical is subject to many factors and is volatile.
First, the price of raw materials fluctuates, which is deeply affected by the cost of 3-chloro-5- (difluoromethoxy) Pyridine. If the price of various raw materials required for its preparation fluctuates due to the weather, geographical location, and supply and demand, the price of the finished product will also fluctuate.
Second, the process of preparing this chemical is difficult, and it is also related to cost and price. If the process is complicated and requires many steps, exquisite equipment and professional manpower, the price will be high; if the process becomes simpler and more efficient, the cost will decrease and the price may also decline.
Third, the state of market supply and demand is the key to the price. If the market demand for this chemical is strong, but the supply is limited, the price will rise; conversely, if the supply is abundant and the demand is limited, the price may fall.
Fourth, the number of manufacturers and the competitive situation also affect the price. There are many manufacturers, and the competition is fierce. In order to compete for market share, there may be price cuts; if there are few manufacturers and they are almost monopolized, the price can be high.
Fifth, policies and regulations and the international trade situation also have an impact. If environmental regulations become stricter, manufacturers will increase costs for compliance production, and prices may rise; variables such as tariffs and trade barriers in international trade will also make prices unstable.
In summary, to know the exact market price of 3-chloro-5- (difluoromethoxy) Pyridine, it is necessary to check the chemical market information in real time and consult relevant suppliers to obtain current and accurate price information.