As a leading 3-Chloro-5,6-Dihydro-1-(4-Nitrophenyl)2(1H)-Pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 3-Chloro-5,6-Dihydro-1- (4-Nitrophenyl) 2 (1H) -Pyridine?
3-Chloro-5,6-dihydro-1- (4-nitrophenyl) -2 (1H) -pyridine is widely used in the field of chemical synthesis.
First, it is a key intermediate in the creation of medicine. The development of many new drugs relies on its participation in the reaction to construct a specific molecular structure and endow the drug with unique pharmacological activity. For example, a certain type of anti-arrhythmic drug uses it to build a core pyridine ring structure. After subsequent derivatization, the drug has a precise effect on the cardiac ion channel and regulates the heart rhythm to normal.
Second, in the field of materials science, it also shows its ability. For example, the preparation of special optoelectronic materials, by virtue of the characteristics of chlorine atoms, nitrophenyl groups and other groups in their structure, regulates the electron cloud distribution of the material, so that the material obtains excellent photoelectric conversion performance, which is expected to be used in high-efficiency solar cells, Light Emitting Diode and other devices, adding new power to the field of energy and optoelectronics.
Third, in the field of organic synthetic chemistry, it is an important cornerstone for the construction of complex organic molecules. Due to the activity of the pyridine ring and surrounding substituents, various organic reactions, such as nucleophilic substitution, electrophilic substitution, etc., can be used to introduce different functional groups, expand the diversity of molecules, and pave the way for the synthesis of various functional organic compounds. It has made great contributions to the manufacturing of fine chemicals and other fields.
What are the synthesis methods of 3-Chloro-5,6-Dihydro-1- (4-Nitrophenyl) 2 (1H) -Pyridine
The synthesis methods of 3-chloro-5,6-dihydro-1- (4-nitrophenyl) -2 (1H) -pyridine are diverse. In the past, Fang family, or follow the ancient method of organic synthesis, started with common pyridine derivatives, by chlorination, nitrification and hydrogenation, and made in sequence.
At first, choose pyridine compounds, in a specific reaction kettle, control temperature and pressure, meet with chlorine-containing reagents, and apply chlorination to make chlorine atoms suitable and attached to obtain chloropyridine intermediates. This step requires careful selection of reagents and conditions to prevent side reactions from resulting in impure products. < Br >
Then, nitro is introduced into the obtained intermediate. With a nitrogenation reagent, such as a mixed acid (a mixture of nitric acid and sulfuric acid), in the right environment, the nitro group falls on the para-phenyl group of the pyridine ring to form a nitro-containing pyridine. However, in this process, the concentration, temperature and reaction duration of the acid must be precisely controlled, otherwise the nitro group will be misconnected and the synthesis will be bad.
The final hydrogenation step is crucial. The dihydro site of the pyridine ring is hydrogenated with a hydrogenation reagent, such as hydrogen and a suitable catalyst (such as palladium carbon, etc.), to obtain the target product 3-chloro-5,6-dihydro-1- (4-nitrophenyl) -2 (1H) -pyridine. During hydrogenation, the catalyst activity, hydrogen pressure and reaction temperature all affect the yield and purity of the product.
Or there are other methods, such as using the coupling reaction as the basis, connecting the chloropyridine-containing fragment with the nitrobenzene fragment through a suitable coupling agent and catalytic system, so that it can also achieve the purpose of synthesis. These new methods can often simplify the process, improve the yield and purity, and are the best way to synthesize. The technology of synthesis often advances with technology, and new reagents and new catalytic systems continue to emerge. In the future, there may be better methods to be explored by various experts.
What are the physical properties of 3-Chloro-5,6-Dihydro-1- (4-Nitrophenyl) 2 (1H) -Pyridine
3-Chloro-5,6-dihydro-1- (4-nitrophenyl) -2 (1H) -pyridine This substance has important physical properties and is relevant to many fields of chemical applications.
First of all, the appearance of this substance is usually presented in a specific form. It is either a crystalline body with a regular and orderly crystal structure and a unique geometric shape. It may have a bright luster under light, just like stars shining in the dark night sky; or it is in the shape of a powder, delicate as dust, uniform in texture, and silky to the touch.
Looking at its color, the common color is either colorless and transparent, like pure water, clear to the bottom, without any impurities; or yellowish, like early morning sunlight, soft and elegant, revealing a kind of rustic beauty.
The melting point of this object is one of its important physical properties. If the melting point is established, under a specific temperature, this substance gradually melts from a solid state to a liquid state, such as ice and snow melting in the warm sun. The value of this melting point can be a key indicator for identifying the authenticity and purity of this substance, just like a precise ruler to measure its quality.
The boiling point cannot be ignored. When the temperature rises to the boiling point, the substance is converted from a liquid state to a gaseous state, like a cloud rising between heaven and earth. The boiling point is closely related to the forces between molecules, reflecting the strength of the mutual binding between molecules.
Solubility is also an important consideration. In different solvents, its solubility characteristics are different. In some organic solvents, such as ethanol and ether, it may be soluble, just like salt melts in water, invisible and invisible, fused together; in water, its solubility may be different, slightly soluble, or insoluble, just like sand and gravel in clear water, clearly recognizable.
In addition, density is also one of its physical properties. The density depends on its state of sinking and floating in the liquid. If the density is greater than that of the solvent, it will sink at the bottom, just like a boulder entering water; if it is less than the solvent, it will float on the surface, just like a light boat floating above the blue waves.
These physical properties are related and affect each other, and together outline the unique physical appearance of 3-chloro-5,6-dihydro-1- (4-nitrophenyl) -2 (1H) -pyridine, which is of great significance in chemical research, industrial production and many other aspects.
What are the chemical properties of 3-Chloro-5,6-Dihydro-1- (4-Nitrophenyl) 2 (1H) -Pyridine
The chemical properties of 3-chloro-5,6-dihydro-1- (4-nitrophenyl) -2 (1H) -pyridine have been investigated.
Firstly, from the structural point of view, the presence of chlorine atoms endows it with certain nucleophilic substitution reactivity. As an electron-absorbing group, chlorine atoms can change the density distribution of electron clouds on the pyridine ring, so that the density of adjacent and para-position electron clouds is relatively reduced, and it is easier to be replaced at a suitable check point when nucleophilic reagents attack.
Furthermore, the structure of 5,6-dihydropyridine has a certain unsaturation and can participate in reactions such as hydrogenation and reduction. Under suitable conditions, this unsaturated structure can be added to hydrogen and converted into saturated pyridine derivatives, which is of great significance for adjusting the overall activity and properties of the molecule.
And the 1 - (4 - nitrophenyl) part, the nitro group is a strong electron-absorbing group, which not only affects the electron cloud distribution of the benzene ring, but also enhances the polarity of the whole molecule. This not only affects its solubility, but also stabilizes the reaction intermediates through resonance effects in some reactions, which in turn affects the reaction path and rate. For example, in nucleophilic substitution reactions, nitro groups can make the benzene ring ortho and para-sites more vulnerable to nucleophilic attack.
In addition, the hydrogen atom at the 2 (1H) -pyridine position is affected by the electronic effect of surrounding groups and has a certain acidity. Under basic conditions, deprotonation reactions may occur to generate corresponding negative ions. As an active intermediate, this negative ion can participate in various subsequent reactions, expanding the application scope of this compound in organic synthesis.
In summary, 3-chloro-5,6-dihydro-1- (4-nitrophenyl) -2 (1H) -pyridine has considerable application potential in the field of organic synthesis due to its unique structure and diverse chemical properties.
What is the price of 3-Chloro-5,6-Dihydro-1- (4-Nitrophenyl) 2 (1H) -Pyridine in the market?
Today there is a question about the market price of 3-chloro-5,6-dihydro-1- (4-nitrophenyl) 2 (1H) -pyridine. However, I have searched all over the ancient books, and I have not found the price of this compound in "Tiangong Kaiwu". The cover of "Tiangong Kaiwu" is to record the skills of hundreds of workers, agricultural production and other things, which are all common and traditional arts at that time. This organic compound has a complex structure and cannot be made in ancient times. There is no value in the book.
If you want to know the current price of this product, you should ask the chemical raw material market and chemical reagent suppliers today. Its price may vary due to purity, output, market supply and demand. If the purity is high, the price will be high; if you buy in large quantities, there may be discounts. In addition, the market of the chemical industry is constantly changing. If you want to get a definite price, you should inquire about the relevant merchants in real time. By means of online platforms, telephone inquiries, etc., you can get a more accurate price. Although "Tiangong Kaiwu" cannot answer this question, today's information is convenient, and there are many ways to know its price.
