3-Chloro-4-pyridineboronicacidhydrate

3-Chloro-4-pyridyl boronic acid hydrate has a wide range of uses and is often a key reagent in the field of organic synthesis. Organic synthesis aims to construct various complex organic molecules, and this compound can be used as an important building block. Due to its unique reactivity, boric acid groups can participate in many classical organic reactions, such as the Suzuki coupling reaction. In the Suzuki coupling reaction, 3-chloro-4-pyridyl boronic acid hydrate can react with halogenated aromatics or halogenated olefins under the action of suitable catalysts and bases to form new carbon-carbon bonds, whereby a series of organic compounds with specific structures and functions can be synthesized, which is of great significance in the fields of medicinal chemistry and materials science.
This compound also plays an important role in drug development. The design and synthesis of drug molecules requires the precise construction of specific chemical structures to achieve the required biological activity. The reaction of 3-chloro-4-pyridyl boric acid hydrate can help to introduce the structure of pyridine ring and the specific substituent groups connected to it. Pyridyl ring is common in many drug molecules. Due to its unique electronic properties and spatial structure, it can affect the interaction between drugs and biological targets, and then endow drugs with specific pharmacological activities.
In the field of materials science, functional organic materials can be prepared by using 3-chloro-4-pyridyl boric acid hydrate through organic synthesis reactions. For example, the synthesis of conjugated polymer materials with specific photoelectric properties shows potential application value in the fields of Light Organic Emitting Diode (OLED) and organic solar cells. It can adjust the molecular structure and electronic structure of the material by participating in the polymerization reaction, thereby optimizing the photoelectric properties of the material.

There are two common methods for preparing 3-chloro-4-pyridine boric acid hydrate. First, 3-chloro-4-bromopyridine is used as the starting material. First, 3-chloro-4-bromopyridine is dissolved in an anhydrous organic solvent such as tetrahydrofuran, and n-butyllithium is slowly added dropwise at a low temperature environment, such as minus 78 degrees Celsius. N-butyllithium and 3-chloro-4-bromopyridine undergo lithium halogen exchange reaction to generate the corresponding lithium reagent. Subsequently, a borate ester, such as trimethyl borate, is added to the system and warmed to room temperature to react the lithium reagent with trimethyl borate. After the reaction is completed, through the hydrolysis step, the reaction mixture can be treated with dilute acid to obtain 3-chloro-4-pyridyl boronic acid, and then its hydrate can be obtained. In this process, anhydrous and anaerobic operation is very critical, otherwise the lithium reagent is easy to react with water and oxygen to cause side reactions.
Second, 3-chloropyridine is used as a raw material. 3-chloropyridine first reacts with a strong base, such as potassium tert-butyl alcohol, to form a pyridine negative ion intermediate. Next, a halogenated boron reagent, such as pinacol borane, is added to the system, and a boration reaction occurs under the action of a transition metal catalyst, such as a palladium This palladium catalyst can activate the halogenated boron reagent and promote its binding to the pyridine negative ion intermediate. After the reaction, 3-chloro-4-pyridine boronic acid can be obtained by appropriate post-treatment, such as extraction, column chromatography, etc. The target product can be obtained by hydration operation 3-chloro-4-pyridine boronic acid hydrate. In this route, catalyst selection and reaction conditions are very important, which are related to reaction yield and selectivity.

3-Chloro-4-pyridyl-boronic acid hydrate is an important compound in organic chemistry. Its physical properties are unique and worthy of detailed investigation.
When it comes to appearance, 3-chloro-4-pyridyl-boronic acid hydrate is often in the state of white to white crystalline powder. This morphological characteristic is of great significance in the preliminary identification and judgment of compounds. White to off-white indicates that its purity is high, and the state of crystalline powder shows that its molecules are arranged in an orderly manner and have certain crystal structure characteristics.
Looking at its solubility, the compound exhibits some solubility in organic solvents such as methanol, ethanol, dichloromethane, etc. In methanol and ethanol, it can be moderately dissolved by virtue of the hydrogen bonds and van der Waals forces formed between its molecules and solvent molecules. In dichloromethane, although its solubility may not be as good as that of alcohols, it can also be dispersed to a certain extent. This property provides a key basis for its extraction, separation, and reaction medium selection in organic synthesis.
Melting point is also one of the important physical properties. The melting point of 3-chloro-4-pyridyl boric acid hydrate is within a specific range. This melting point data is of great significance for the determination of the purity of compounds. If the melting point is accurate and the melting range is narrow, it usually means that the purity of the compound is quite high; conversely, if the melting range is wide, it may imply the existence of impurities, which affects its chemical properties and applications.
In terms of stability, 3-chloro-4-pyridyl boronic acid hydrate still has certain stability under conventional environments. However, under extreme conditions such as high temperature, high humidity or strong acid and alkali, its structure may change. Under high temperature, the vibration of chemical bonds in the molecule intensifies, or some chemical bonds break; in high humidity environment, water molecules interact with compounds or change their hydration state; strong acid and alkali may cause acid-base reactions, resulting in changes in its structure and properties. Therefore, when storing and using, careful attention should be paid to environmental conditions.
In summary, the physical properties of 3-chloro-4-pyridyl boronic acid hydrate, from appearance, solubility, melting point to stability, play a crucial role in its applications in organic synthesis, pharmaceutical research and development, and many other fields.

3-Chloro-4-pyridyl boronic acid hydrate should be stored in a cool, dry and well-ventilated place. This compound is afraid of moisture, which can easily cause deterioration and damage its chemical properties and purity. Therefore, it must be avoided in a humid place, such as in a sealed container with a desiccant.
And because it is also sensitive to heat, high temperature can cause it to decompose or cause chemical reactions, which can damage its quality. Therefore, the storage temperature should be controlled at room temperature or lower, generally not exceeding 25 ° C. And light may also affect its stability, so it should be stored in a dark place, or stored in an opaque container. < Br >
When storing, also pay attention to isolation from other chemicals to prevent mutual reaction. After taking it, the container must be sealed in time and returned to its original place to ensure that its storage environment is constant. In this way, it can be stored for a long time and the quality is safe for subsequent experiments and production, so that its chemical properties are stable and its utility can be fully developed.

3-Chloro-4-pyridyl boronic acid hydrate is on the market, and its price range is difficult to determine. Due to various reasons, its price has changed.
First, the origin and purity of the material have a great impact. If the source is wide and pure, the price may be relatively easy; if the source is thin and difficult to purify, the price will be high.
Second, the supply and demand situation of the city is very important. If there are many needs and few suppliers, the price will increase; if the supply exceeds the demand, the price may drop.
Third, the complexity of the process also affects the price. The more complex the process, the more manpower and material resources required, and the price will also rise.
From the perspective of "Tiangong Kaiwu", the price of all kinds of products changes according to various conditions. If it is a metallurgical casting genus, the ore source is abundant and the melting and casting are difficult, so the price is different. The same is true for this 3-chloro-4-pyridyl boronic acid hydrate.
Roughly speaking, in today's market, the price per gram may range from tens to hundreds of yuan. However, this is only an approximate number. The actual price should vary according to the current market conditions, the quantity purchased, and the different suppliers. Buyers should carefully observe the market conditions and inquire from many parties before they can get a suitable price.