3-Chloro-4-cyanopyridine

3-Chloro-4-cyanopyridine is also an organic compound. It has a wide range of uses and is an important intermediate for the synthesis of many drugs in the field of medicinal chemistry. Because of its unique molecular structure, the chlorine atom and cyanyl group can be combined with other molecules through various chemical reactions to build a complex drug molecular structure.
For example, when developing antibacterial drugs, 3-chloro-4-cyanopyridine can introduce key structural fragments through specific reaction steps to give the drug inhibitory activity against specific pathogens. It also plays an important role in the creation of pesticides. It can be converted into compounds with insecticidal, bactericidal or herbicidal effects by chemical modification. Due to the reactivity check point of this substance, it can participate in a variety of organic synthesis reactions. After design modification, it can exhibit specific activities against different pests, bacteria or weeds.
In addition, in the field of materials science, 3-chloro-4-cyanopyridine also has potential uses. Or it can participate in the synthesis of polymer materials with special properties, such as polymers with specific optical and electrical properties. By introducing it into the polymer chain segment, the properties of the material can be adjusted to meet the needs of different application scenarios.
To sum up, 3-chloro-4-cyanopyridine, with its unique structure, is a valuable chemical raw material in many fields such as medicine, pesticides, and materials science, promoting the development and innovation of various fields.

The synthesis method of 3-chloro-4-cyanopyridine, as mentioned in the ancient books, has several ways.
First, 3-chloro-4-methylpyridine is used as the starting material. First, 3-chloro-4-methylpyridine is met with a suitable oxidant, such as potassium homomonate, etc. After oxidation, the methyl group can be converted to a carboxyl group to obtain 3-chloro-4-pyridine carboxylic acid. Then, this acid is mixed with thionyl chloride, heated and dance together, and the carboxyl group can be converted into an acyl chloride to obtain 3-chloro-4-pyridyl formyl chloride. Then let it and potassium cyanide in a suitable solvent, such as N, N-dimethylformamide, at a suitable temperature and conditions, the acyl chloride can be replaced by a cyano group to obtain 3-chloro-4-cyanopyridine.
Second, take 3-chloropyridine as the initial thing. First, 3-chloropyridine is lithiated with a suitable base, such as n-butyl lithium, at a low temperature environment, and lithium atoms are introduced at the 4th position of the pyridine ring. Subsequently, cyanide reagents such as cuprous cyanide are added, and lithium atoms are transposed with cyano groups to obtain 3-chloro-4-cyanopyridine. This approach requires attention to the reaction temperature and the amount of reagents to ensure a smooth reaction.
Third, start with 4-cyanopyridine. Under the appropriate catalyst, such as the mixed system of iron powder and hydrochloric acid, or the catalysis of palladium carbon, chlorine gas or chlorine-containing reagents, such as thionyl chloride, is used to chlorinate the 3-position of the pyridine ring, so that 3-chloro-4-cyanopyridine can also be obtained. However, this process requires precise control of the reaction conditions to avoid side reactions such as excessive chlorination.
All synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs, availability of raw materials, and cost considerations.

3-Chloro-4-cyanopyridine, this is an organic compound with unique physical properties. Under normal temperature and pressure, it is in the shape of a solid state, and it usually appears white to light yellow crystalline powder. This color is easy to identify.
When it comes to the melting point, it is about 126-130 ° C. When the temperature reaches this range, the substance gradually melts from solid to liquid. This characteristic is a key parameter in chemical production and analysis. Due to the accurate determination of the melting point, it can help to judge its purity.
In terms of boiling point, it is usually around 320 ° C. At this temperature, the substance changes from liquid to gaseous state. The level of boiling point is related to the degree of volatilization during heating, and is of great significance to the temperature control of related processes.
Its solubility is also an important physical property. 3-Chloro-4-cyanopyridine exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc., and can be miscible with it. However, its solubility in water is relatively poor, and this property needs to be taken into account when separating, purifying and constructing reaction systems.
In addition, the density of the substance is also a specific value. Although the specific value varies slightly due to the measurement conditions, it is roughly within a certain range. This density parameter is indispensable in material calculation and related process design. Its physical properties such as appearance, melting point, boiling point, solubility, and density lay the foundation for the study of its chemical behavior and practical application, and are of great value in many fields such as organic synthesis and medicinal chemistry.

3-Chloro-4-cyanopyridine, the price of this substance in the chemical market, it is difficult to say in a word. The price of this compound often changes due to various reasons, just like the situation changes, and it is impermanent.
First, the price of raw materials is the key end. The production of this compound depends on specific raw materials. If the production of raw materials is abundant and the price rises and falls, the price of 3-chloro-4-cyanopyridine will also fluctuate. If the raw materials are abundant and the price is flat, the cost of the system is light, and the market price may be cheap; if the raw materials are scarce and expensive, the cost will increase, and the price will increase.
Second, the trend of supply and demand also affects its price. If there are many people in the market, and it is used in various industries such as medicine and pesticides, the demand is strong, and the supply is limited, the price will rise; on the contrary, if the demand is weak and the supply exceeds the demand, the price will drop.
Third, the simplicity of the process is related to the cost and price. Sophisticated craftsmanship may reduce costs and yield. However, if the process is complicated, the cost of equipment and manpower will increase greatly, which will also increase the cost and change the price.
Fourth, the changes in the current situation cannot be ignored. Trade policies and tax regulations can all affect their prices. Trade barriers are high, which may hinder the circulation of raw materials and finished products, increase costs and increase prices; different taxes also make prices vary.
Looking at past prices, or at different times and regions, there are great fluctuations. At some times, the price may be at [X] yuan per kilogram; and elsewhere, or for the above reasons, the price is at [Y] yuan per kilogram.
In short, in order to know the current market price of 3-chloro-4-cyanopyridine, it is necessary to consult chemical suppliers and trading platforms in real time, and carefully consider changes in various market factors in order to obtain a more accurate price.

For 3-chloro-4-cyanopyridine, many matters need to be paid attention to during storage and transportation.
The first thing to bear the brunt is the storage environment. This substance should be placed in a cool, dry and well-ventilated place. Because it is afraid of moisture and the humid air is prone to deterioration, the humidity in the warehouse should be strictly controlled and should not exceed a specific value. And the temperature should not be too high, high temperature or chemical reaction should be caused, which will damage its quality. In the warehouse, it should be kept away from fire and heat sources to prevent accidental explosion.
Furthermore, it should be carefully mixed with other substances. 3-Chloro-4-cyanopyridine should not be stored and transported with oxidants, acids, alkalis, etc. Due to its active chemical properties, it encounters with them or reacts violently, endangering safety. It must be stored separately and clearly marked to distinguish.
When transporting, the packaging must be tight. The packaging materials used must have good sealing and corrosion resistance to prevent leakage. During loading and unloading, the operator should handle it with care and do not operate it brutally to avoid damage to the packaging. The transportation vehicle should also be clean and dry, and no other chemicals should be left behind.
In addition, whether it is storage or transportation, a special person needs to be responsible for supervision. Regularly check the temperature and humidity of the storage environment, the integrity of the packaging, etc. Once any abnormalities are found, immediate measures must be taken, such as ventilation, repair of the packaging, etc., to ensure the safe storage and smooth transportation of 3-chloro-4-cyanopyridine.