3 Chloro 2 Pyridinecarbonitrile
pyridine pyrrole pyrazine piperidine piperazine

3-Chloro-2-pyridinecarbonitrile

    Specifications

    HS Code

    350632

    Chemical Formula C6H3ClN2
    Molecular Weight 138.55
    Appearance Solid (Typical)
    Melting Point 63 - 67 °C
    Boiling Point 264.3 °C at 760 mmHg
    Density 1.35 g/cm³
    Solubility In Water Insoluble
    Flash Point 113.6 °C
    Vapor Pressure 0.0123 mmHg at 25 °C
    Logp 1.49

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    General Information
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    Frequently Asked Questions

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    What is the chemistry of 3-Chloro-2-pyridinecarbonitrile?
    3-Chloro-2-pyridine nitrile, this is an organic compound. Its chemical properties are unique and valuable for investigation.
    Looking at its structure, the pyridine ring is related to the cyano group and the chlorine atom, and this structure gives it special chemical activity. Because the cyanide group has strong electron absorption, it can reduce the electron cloud density of the pyridine ring, making it more susceptible to electrophilic attack. Although the chlorine atom is also an electron-absorbing group, it can form a reactive activity check point under specific conditions.
    On reactivity, in the nucleophilic substitution reaction, the chlorine atom can be replaced by a variety of nucleophilic reagents. For example, by co-heating with sodium alcohol, chlorine atoms may be replaced by alkoxy groups to form corresponding ether derivatives; by reacting with amines, nitrogen-containing substitutions can be obtained. Such reactions are based on the tendency of chlorine atoms to leave, and nucleophiles attack them to break carbon-chlorine bonds and build new bonds.
    In alkaline environments, 3-chloro-2-pyridineformonitrile may have different reaction paths. Cyanyl groups can be hydrolyzed into carboxyl groups or amide groups, and this hydrolysis reaction is affected by factors such as alkali concentration and temperature. Under moderate conditions, cyano groups are first converted to amide groups. If the conditions are more severe, the amide groups can be further hydrolyzed into carboxyl groups.
    And because of the existence of the pyridine ring, 3-chloro-2-pyriformonitrile can participate in metal-catalyzed reactions. For example, in the coupling reaction catalyzed by palladium, the pyridine ring can coordinate with metals, stabilize the catalytic active center, and promote the formation of carbon-carbon bonds or carbon-heteroatomic bonds. It is of great significance in the field of organic synthesis and can be used to construct complex organic molecular structures.
    In short, 3-chloro-2-pyriformonitrile exhibits diverse chemical properties due to its unique structure. It has great potential for application in organic synthesis, medicinal chemistry and other fields. It can be used as a key intermediate for the creation of various functional compounds.
    What are the common synthetic methods of 3-Chloro-2-pyridinecarbonitrile?
    3-Chloro-2-pyridylmethonitrile is also a compound commonly used in organic synthesis. The common synthesis methods are about a few.
    First, pyridine is used as a group. Under appropriate reaction conditions, the cyanide group can be introduced into the pyridine, and the cyanidation reaction can be carried out by means of cyanide reagents, such as potassium cyanide, etc., under the action of suitable solvents and catalysts. Then, the chlorine atom is introduced at a specific position in the pyridine ring, that is, at the 3rd position. A suitable chlorination reagent can be selected, such as thionyl chloride, phosphorus oxychloride, etc., at a suitable temperature and reaction time, the chlorination step is completed, and 3-chloro-2-pyridyl formonitrile is obtained.
    Second, 2-pyridyl formonitrile is used as the starting material. The compound is chlorinated, and the chlorination reagent is used to selectively connect the chlorine atom at the third position of the pyridyl ring. During this process, attention should be paid to the precise control of the reaction conditions, such as the reaction temperature, reaction time, and the amount of chlorination reagent, because these factors will affect the selectivity and yield of the reaction. If the temperature is too high or the chlorination reagent is too high, it may cause the formation of polychlorinated by-products, which will affect the purity and yield of the target product.
    Third, other compounds containing pyridine structures can also be used as starters, and cyanyl groups and chlorine atoms are gradually introduced through a series of functional group conversion reactions. For example, the starter is first introduced into the pyridine ring through a specific reaction, which can be converted into cyanyl groups, and then the conversion reaction is carried out to generate cyano groups. Then, when appropriate, chlorine atoms are introduced at 3 positions by means of chlorination, and the final target product is 3-chloro-2-pyridylmethonitrile. This path requires a good understanding of the mechanism and conditions of each step of the reaction to ensure the smooth progress of the reaction and the efficient synthesis of the target product.
    3-Chloro-2-pyridinecarbonitrile in what areas
    3-Chloro-2-pyrimethonitrile is widely used in the fields of chemical industry and medicine.
    In the chemical industry, it is an important intermediate for the synthesis of special organic materials. It can be combined with a variety of organic reagents through specific chemical reactions to prepare polymers with unique properties. It has great potential in the modification and strengthening of materials, or can make materials better heat resistance, corrosion resistance and other characteristics, and is indispensable in the manufacture of high-end materials.
    In the field of medicine, this compound also has extraordinary power. Due to its unique chemical structure, it has potential biological activity. Pharmaceutical developers often use this as a starting material to create new drugs through a series of delicate chemical modifications and reactions. Or they can design drug molecules that fit the pathogenic mechanism of specific diseases, and show broad application prospects in many drug development directions such as anti-cancer and anti-infection.
    And because of the presence of chlorine atoms and cyanide groups in its structure, it has special reactivity and can participate in diverse reaction pathways, providing rich possibilities for innovative research in the chemical and pharmaceutical fields, and promoting the continuous progress and development of related fields.
    What is the market outlook for 3-Chloro-2-pyridinecarbonitrile?
    3-Chloro-2-pyridinonitrile, a crucial chemical raw material in the field of organic synthesis, plays an indispensable role in the preparation of many drugs, pesticides and fine chemicals. Looking at its market prospects, it is indeed a bright one, and many factors have combined to create its vigorous development trend.
    In the field of medicine, with the acceleration of the global population aging process and the rising incidence of various diseases, the demand for new drugs is also increasing day by day. 3-chloro-2-pyridinitrile, as a key intermediate, can be used to synthesize a variety of drugs with unique pharmacological activities. For example, in the field of anti-tumor drug research and development, compounds derived from this raw material have been shown to have significant inhibitory effects on specific tumor cells and are expected to become the core components of a new generation of anti-cancer drugs. Such potential applications will undoubtedly win a broad development space for it in the pharmaceutical market.
    The field of pesticides is also an important application of 3-chloro-2-pyrimethonitrile. With the increasing emphasis on the quality and safety of agricultural products and environmental protection, the development of high-efficiency, low-toxicity and environmentally friendly pesticides has become the mainstream trend in the industry. With its unique chemical structure, 3-chloro-2-pyriformonitrile can be derived from a series of pesticide products with excellent insecticidal and bactericidal properties. Compared with traditional pesticides, such products have less impact on the environment and are less toxic to non-target organisms. Therefore, in the context of the continuous pursuit of green and sustainable development of the global pesticide market, its market demand is bound to grow steadily.
    Furthermore, the demand for 3-chloro-2-pyriformonitrile in the fine chemical industry should not be underestimated. In the synthesis process of fine chemicals such as dyes, fragrances, and functional materials, this compound is often used as a key structural unit, giving the product unique properties and quality. With the improvement of people's living standards, the quality and functional requirements for various fine chemicals are becoming increasingly diverse, which will undoubtedly further promote the application and expansion of 3-chloro-2-pyridyl formonitrile in this field.
    To sum up, 3-chloro-2-pyridyl formonitrile, with its wide application prospects in many fields such as medicine, pesticides and fine chemicals, will surely capitalize on the development of various industries in the future market, ushering in broader development opportunities and market space.
    What are 3-Chloro-2-pyridinecarbonitrile storage conditions?
    3-Chloro-2-pyrimethonitrile is also a chemical substance. Its storage conditions are crucial, related to its quality and safety.
    This substance should be stored in a cool and dry place. A cool environment can prevent the chemical properties of the substance from changing due to excessive temperature. If it is exposed to high temperature, or it may cause adverse reactions such as decomposition and polymerization, it will damage its chemical structure and lose its original characteristics. A dry place is also indispensable. Due to moisture or hydrolysis, other impurities will be formed, which will affect its purity and performance.
    And it must be placed in a well-ventilated place. Good ventilation can disperse harmful gases that may evaporate and reduce the risk of explosion and poisoning. At the same time, the storage place should be kept away from fire sources, heat sources and oxidants. Fire sources and heat sources can easily cause them to burn or even explode, and oxidants come into contact with them, or induce violent chemical reactions, which are very harmful.
    In addition, storage containers should also be carefully selected. Corrosion-resistant containers should be selected to prevent the material of the container from reacting with the substance and then contaminating the substance. During storage, the sealing condition of the container should also be checked regularly. If the seal is not good, the substance or leakage will pollute the environment and endanger personal safety.
    In addition, obvious warning signs must be posted at the storage place to make the contacts aware of the danger and operate with caution. Only by following the above storage conditions can the stable storage of 3-chloro-2-pyridinitrile be ensured and the latent risk can be reduced.