3-Chloro-2-hydroxypyridine

3-Chloro-2-hydroxypyridine is one of the organic compounds. Its physical properties are quite characteristic, and this is for you to explain in detail.
Looking at its morphology, under room temperature and pressure, it is mostly white to light yellow crystalline powder, which is easy to identify and use.
When it comes to the melting point, it is about 128-132 ° C. The characteristics of the melting point are particularly critical in experimental operations such as the identification and purification of substances. This temperature can be used as a standard to determine its purity, and it is also an important reference in the synthesis process.
As for solubility, it has a certain solubility in water. Water is a common solvent, which can dissolve here, indicating that there is a specific interaction between it and water molecules. And it also shows good solubility in organic solvents such as ethanol and acetone. This solubility allows researchers to have more strategies when selecting reaction media and separating and purifying products. For example, in some organic synthesis reactions, ethanol can be selected as a solvent according to its solubility, so that the reaction can proceed smoothly and the subsequent product separation is also convenient.
Although its density is not a very precise value, it is roughly fixed. The appropriate density range is related to the distribution and mixing state of substances in the reaction system. In liquid-liquid reactions or heterogeneous reactions, density factors can affect the mass transfer and reaction rate of substances.
In addition, 3-chloro-2-hydroxypyridine has a certain stability, but it will also react chemically under certain conditions, such as strong acid, strong alkali environment, or high temperature and light. Knowing this stability, researchers can take corresponding protective measures when storing and using the compound, such as avoiding strong light, storing it in a cool and dry place, and keeping it away from acid and alkali substances to keep its chemical properties unchanged.

3-Chloro-2-hydroxypyridine, an organic compound, has unique chemical properties and is widely used in many fields.
First of all, its acidity and alkalinity. The presence of the 2-position hydroxyl group makes it acidic to a certain extent. The oxygen atom in the hydroxyl group has high electronegativity and is strongly attracted to the hydrogen-oxygen bond electron cloud, so that the hydrogen atom is easily dissociated in the form of protons, so it can react with the base to form corresponding salts.
Let's talk about its nucleophilic substitution reaction. The 3-position chlorine atom has high activity and is vulnerable to attack by nucleophilic reagents, resulting in nucleophilic substitution. Because the electronegativity of chlorine atoms is greater than that of carbon atoms, the electron cloud of carbon-chlorine bonds is biased towards chlorine, and the carbon atoms are partially positively charged, and nucleophiles are easy to combine with them, while the chlorine atoms leave in the form of chloride ions. This reaction is commonly used in the synthesis of complex pyridine derivatives.
3-chloro-2-hydroxypyridine can also participate in coordination reactions. Hydroxyl oxygen atoms and pyridine cyclic nitrogen atoms contain lone pairs of electrons, which can be used as ligands to coordinate with metal ions to form metal complexes. These complexes have potential applications in catalysis, materials science, etc., or exhibit unique catalytic activity and optical and electrical properties.
In addition, its stability is also worthy of attention. Although relatively stable, under extreme conditions such as high temperature, strong acid, and strong base, the molecular structure may change. For example, decomposition reactions may occur at high temperatures; in strong acids and strong bases, hydroxyl groups or chlorine atoms react, resulting in molecular structure changes.
In short, 3-chloro-2-hydroxypyridine has important value in organic synthesis, medicinal chemistry, and materials science due to its unique chemical properties. In-depth investigation of its properties can expand its application range and promote the development of related fields.

The common synthesis of 3-chloro-2-hydroxypyridine is an important matter in the field of chemical synthesis. The synthesis paths are diverse, and the common methods are described in detail today.
First, pyridine is used as the starting material. First, pyridine is halogenated, and under suitable reaction conditions, such as in a specific solvent, it can be treated with appropriate halogenating reagents to obtain chloropyridine. Later, by means of hydroxylation steps, hydroxyl groups are introduced. This hydroxylation process requires specific bases and nucleophiles, and under suitable temperature and time control, the conversion to 2-hydroxyl groups can be achieved, and then 3-chloro-2-hydroxypyridine can be obtained. < Br >
Second, starting from a suitable precursor compound containing chlorine and hydroxyl groups. Pyridine rings are constructed through ingenious cyclization reactions. For example, some chain-like compounds with specific functional groups are cyclized in molecules under suitable catalysts and reaction environments to form pyridine structures, while retaining chlorine and hydroxyl groups in the desired positions. This is also an effective way to synthesize 3-chloro-2-hydroxypyridine.
Third, metal-catalyzed coupling reactions. Select suitable halogenated aromatics and hydroxyl-containing pyridine derivatives, and under the action of metal catalysts, such as palladium, copper and other metal catalysts, with the assistance of ligands and bases, realize the coupling of carbon-carbon or carbon-heteroatoms, so as to accurately synthesize 3-chloro-2-hydroxypyridine.
All synthesis methods have advantages and disadvantages, and the optimal synthesis strategy should be selected according to actual needs, considering the availability of raw materials, the difficulty of reaction conditions, the yield, and the convenience of subsequent separation and purification.

3-Chloro-2-hydroxypyridine is widely used in various fields. Looking at its genus of medicine and chemical industry, it is quite useful. In the way of pharmaceuticals, this compound is often a key intermediate. Doctors make antibacterial and anti-inflammatory medicines, relying on it as a base, through complex chemical reactions, to become an effective medicine to heal the suffering of sentient beings.
As for the field of materials science, it can also be seen. Or it can be used to create special polymer materials, whose unique chemical structure makes the materials have specific properties, such as enhancing the stability of materials, improving their electrical and thermal conductivity, and contributing to material innovation.
In the field of agriculture, 3-chloro-2-hydroxypyridine can also be used. It can be used as a raw material for pesticide synthesis, an agent for insect control and disease resistance, a crop for protecting farmers and mulberry, ensuring the abundance of grains, and helping the prosperity of agriculture.
It is also an important object of chemical research on the road of scientific research and exploration. Chemists use it to explore the reaction mechanism, open up a new territory of chemical cognition, provide many opportunities and clues for the development of chemistry, and lead the boat of scientific research to break through the waves and sail into the depths of unknown chemical mysteries.

The market price of 3-chloro-2-hydroxypyridine is difficult to determine. The change in its price depends on many reasons.
First, the trend of supply and demand is the main reason for the price. If there are many people in the market, but the supply is small, the price will rise; if the supply exceeds the demand, the price will drop. In today's world, chemical industries, medicines, pesticides, etc., may use this product as a material. When medicine is developed, if it is a key agent, and the research and development progress is fast, the need is more, and the market price will rise.
Second, the cost of production is also the level of the price. The price of raw materials is the cost factor. If the price of the raw material for making 3-chloro-2-hydroxypyridine fluctuates suddenly, the cost of its production will change, and the market price will also follow. And the preparation method, if new technology is used, can reduce the cost, and the price may drop; if the technology is old and expensive, the price will be difficult to lower.
Third, time and place also affect the price. At different times, such as the New Year, the season of prosperity, the price may be different. Different places, different transportation costs, and differences in taxes all lead to different prices.
Looking at the past examples of various cities, the price is always changing. In the past, it may have hovered between tens of yuan and hundreds of yuan per kilogram. However, if you want to know the price, you need to carefully observe the current market conditions, consult the industry, brokers, or observe the platform of chemical trading, in order to obtain a near-real price.