3-CHLORO-2-HYDRAZINO-5-(TRIFLUOROMETHYL) PYRIDINE

3-Chloro-2-hydrazinyl-5- (trifluoromethyl) pyridine, this is an organic compound with unique chemical properties and is crucial in the field of organic synthesis.
First of all, its physical properties are white to light yellow powder at room temperature, or in a solid state. Because its structure contains chlorine atoms, hydrazine groups and trifluoromethyl groups, it has a certain melting point and boiling point. Chlorine atoms are highly electronegative, which can enhance the intermolecular force and increase the melting point and boiling point; trifluoromethyl fluorine atoms are extremely electronegative, which increases the hydrophobicity of the compound.
In terms of chemical activity, hydrazinyl groups are active groups and have strong nucleophilic properties. Nucleophilic addition reactions can occur with a variety of electrophilic reagents, such as aldose and ketone, to form new carbon-nitrogen bonds and synthesize a variety of nitrogen-containing heterocyclic compounds. For example, by reacting with aldose, hydrazone derivatives can be formed, which is an important means to construct specific pharmacophore in the field of medicinal chemistry.
Chlorine atoms can undergo substitution reactions under suitable conditions. Nucleophilic reagents, such as alkoxides, amines, etc., can attack carbon atoms connected to chlorine, replace chlorine, introduce other functional groups, and expand the structural diversity of compounds.
Trifluoromethyl has strong electron-absorbing properties, which can affect the electron cloud distribution of the pyridine ring, reduce the electron cloud density of the pyridine ring, cause its electrophilic substitution activity to weaken, and its nucleophilic substitution activity to increase. This property makes the compound exhibit a reaction path and product that are different from non-trifluoromethyl pyridine derivatives in specific reactions.
Furthermore, the compound is sensitive to acid-base conditions. In acidic environments, hydrazine or protonation changes its nucleophilicity; in alkaline conditions, chlorine atom substitution reactions may occur more easily, or hydrazine groups participate in other reactions, such as interacting with bases to form azene intermediates, triggering subsequent special reactions.
Overall, 3-chloro-2-hydrazinyl-5- (trifluoromethyl) pyridine has a unique structure and is used as a key intermediate in the fields of organic synthesis and drug development. Due to its diverse chemical properties, it can be derived from many compounds with potential application value.

3-Chloro-2-hydrazinyl-5- (trifluoromethyl) pyridine is an important intermediate in organic synthesis and has key uses in many fields.
First, in the field of medicinal chemistry, it plays a pivotal role. Taking the development of antibacterial drugs as an example, its chemical structure can be modified and modified to make it have unique antibacterial activity, which can effectively inhibit the growth and reproduction of specific bacteria. By changing the type, position and quantity of substituents on the pyridine ring, or by derivatization of hydrazine groups, the affinity and selectivity of drugs to bacterial targets can be improved, thereby enhancing the antibacterial effect. In the research and development of anti-cancer drugs, it can be used as a key structural unit to build drug molecules that are cytotoxic or interfere with the metabolic pathways of cancer cells, and help the development of new anti-cancer drugs.
Second, in the field of pesticide chemistry, it is also a key raw material. When used in the creation of insecticides, through rational design of the molecular structure based on this substance, insecticides that have specific effects on the nervous system or physiological and metabolic processes of pests can be developed, with precise impact on pests and relatively small impact on the environment. In the research and development of herbicides, highly selective herbicides can be synthesized according to the physiological characteristics of weeds and their structural characteristics, which only work on specific weeds and do not affect the normal growth of crops.
Third, in the field of materials science, 3-chloro-2-hydrazinyl-5- (trifluoromethyl) pyridine also shows potential application value. For example, it can be used as a starting material for the synthesis of organic materials with special optical and electrical properties. By polymerization with other functional monomers, polymer materials with unique photoelectric conversion properties can be prepared, which are expected to be applied to organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices, providing new ways to improve device performance.
In summary, 3-chloro-2-hydrazinyl-5- (trifluoromethyl) pyridine plays an important role in the fields of medicine, pesticides and materials science due to its unique chemical structure, laying the foundation for the development of many innovative products and technologies.

To prepare 3-chloro-2-hydrazinyl-5- (trifluoromethyl) pyridine, you can do it according to the following method.
Take 5- (trifluoromethyl) pyridine-2,3-dichloro as the starting material. In an appropriate reactor, add an appropriate amount of organic solvent, such as N, N-dimethylformamide (DMF), and dissolve 5- (trifluoromethyl) pyridine-2,3-dichloro into it to form a uniform solution.
Subsequently, slowly add a hydrazine reagent, such as anhydrous hydrazine. This process requires careful temperature control and can generally be maintained between 20-40 ° C. Due to the certain activity and danger of hydrazines, improper temperature control is easy to cause the reaction to go out of control. During the reaction, the amino group of hydrazine selectively replaces the chlorine atom at the 3-position to form 3-chloro-2-hydrazine-5 - (trifluoromethyl) pyridine.
When the reaction is asymptotically complete, it can be monitored by thin-layer chromatography (TLC). After the reaction is completed, pour the reaction solution into an appropriate amount of ice water, and precipitate out. Filtration is suctioned to obtain the crude product.
The crude product still contains impurities and needs to be purified by recrystallization. The pure 3-chloro-2-hydrazinyl-5- (trifluoromethyl) pyridine crystals can be obtained by selecting a suitable solvent, such as a mixed solvent of ethanol and water, through heating and dissolving, cooling crystallization, filtration and other steps.
Another method can also use a pyridine derivative containing a specific substituent as the starting material. After a multi-step reaction, trifluoromethyl is introduced first, and then halogenated, hydrazinylated and other steps, the target product can also be prepared. However, this route has many steps, and the reaction conditions of each step need to be carefully controlled to maintain the overall yield and purity.

3-Chloro-2-hydrazinyl-5- (trifluoromethyl) pyridine is a special chemical substance. When storing, many things must be paid attention to.
The first to bear the brunt is the storage environment. This substance should be stored in a cool and dry place. Because the cool environment can slow down its chemical reaction rate, the dry state can prevent it from being hydrolyzed by moisture to prevent deterioration. If placed in a warm and humid place, it may cause chemical changes and damage its quality.
Furthermore, care must be taken to isolate the air. This substance may react with oxygen, water vapor and other components in the air. Therefore, it is better to store in a sealed container to prevent excessive contact with the outside air. If an airtight glass bottle or a special sealed plastic container is used, it will help to maintain its chemical stability.
The material of the container for storage is also crucial. Materials that can react with this substance should be avoided. In general, glass containers are often preferred due to their chemical stability, but it is necessary to pay attention to some special cases where the glass composition may have a weak reaction with specific chemicals. At this time, specially treated plastic containers may be a better choice, but it is also necessary to ensure that the plastic material does not interact with 3-chloro-2-hydrazine-5 - (trifluoromethyl) pyridine.
At the same time, the storage place should be kept away from fire and heat sources. This chemical substance may be flammable or easily decomposed by heat. In case of open fire or hot topic, it will be dangerous, or cause serious accidents such as combustion and explosion.
In addition, the storage place should be clearly marked, detailing the name, nature and precautions of the substance. In this way, when the relevant personnel take or dispose of it, it can be seen at a glance, reducing the risk of misoperation and ensuring the safety of storage and use.

I look at you and ask "the market price range of 3 - CHLORO - 2 - HYDRAZINO - 5 - (TRIFLUOROMETHYL) PYRIDINE", but the price of this chemical is difficult to determine. The price varies due to many factors, such as supply and demand, quality differences, purchase quantities, difficulty in preparation, market competition and regional differences.
If the supply and demand of this product is very strong and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may drop. Quality is also a key factor. Those with high purity are more expensive, and those with impurities are less expensive. Purchase volume also affects the price. Large purchases can often get discounts, and small retail sales are expensive.
The difficulty of preparation is related to cost. If the synthesis steps are complicated and the raw materials required are rare, the cost will be high and the price will be high. Where the market competition is fierce, merchants may reduce prices to compete for customers; where the competition is weak, the price may be stable but high. And different regions, due to differences in transportation costs, taxes and fees, the price also varies.
Because the above details are not known, it is difficult to determine its price range. For details, you can consult chemical product suppliers, traders, or find relevant price information on professional chemical trading platforms and industry information offices to get a more accurate price range.