3 Chloro 2 Fluoropyridine
pyridine pyrrole pyrazine piperidine piperazine

3-Chloro-2-fluoropyridine

    Specifications

    HS Code

    593608

    Chemical Formula C5H3ClFN
    Appearance colorless to light yellow liquid
    Boiling Point 140 - 142 °C
    Density 1.332 g/mL at 25 °C
    Solubility Soluble in organic solvents
    Flash Point 40 °C

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    General Information
    Where to Buy 3-Chloro-2-fluoropyridine in China?
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    Frequently Asked Questions

    As a leading 3-Chloro-2-fluoropyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3-chloro-2-fluoropyridine?
    The main use of 3-chloro-2-fluoro is in many important fields.
    In the field of medicinal chemistry, it is a key organic synthesis intermediate that can be used to construct compound structures with specific biological activities. Through clever chemical reactions, it can be precisely introduced into the molecular framework of drugs, helping to develop highly effective therapeutic drugs for specific diseases. For example, in the synthesis of some antiviral and anti-tumor drugs, the unique chemical properties of 3-chloro-2-fluoro can make drug molecules more targeted, enhance the ability of drugs to bind to targets, thereby improving drug efficacy and reducing side effects on normal cells.
    In the field of materials science, it also plays an important role. It can be used to prepare high-performance functional materials, such as special fluoropolymers. With its characteristics of fluorine and chlorine atoms, polymers are endowed with excellent chemical resistance, high temperature resistance, and good electrical properties. These properties make these polymers useful in high-end fields such as aerospace and electronics. For example, in the manufacture of aerospace parts, materials prepared with this ingredient can withstand extreme environments and ensure the stable operation of equipment; in the insulation materials of electronic appliances, its good electrical properties can ensure the efficient and safe operation of electronic components.
    In the field of pesticide research and development, 3-chloro-2-fluorine can become a key component of new pesticide molecules. Utilizing its unique chemical activity, pesticide products with high insecticidal and bactericidal activities can be designed and synthesized. Compared with traditional pesticides, such new pesticides based on 3-chloro-2-fluorine may have lower toxicity and higher biodegradability, thus ensuring agricultural production while reducing environmental pollution, in line with the needs of today's green agriculture development.
    To sum up, 3-chloro-2-fluorine, with its special chemical structure and properties, plays an irreplaceable role in medicine, materials, pesticides and other fields, providing strong support for technological progress and innovative development in various fields.
    What are the synthesis methods of 3-chloro-2-fluoropyridine?
    There are many ways to synthesize 3-bromo-2-chlorobenzaldehyde, which are described in detail below.
    First, it is based on halogenation reaction. Benzaldehyde can be taken as the starting material first, and the bromination and chlorination reactions can be carried out in sequence with suitable halogenating reagents, such as brominating agents and chlorinating agents. Under suitable reaction conditions, such as selecting an appropriate solvent, controlling the reaction temperature and time, etc., the bromine atom and the chlorine atom are connected to the benzene ring according to the expected position, that is, the 3-position and the 2-position, respectively. This process requires fine regulation of the reaction conditions to prevent the formation of polyhalogenated by-products.
    Second, through the functional group transformation of aryl halides. First prepare a specific aromatic halide, such as a compound containing bromine or chlorine at a specific position in the benzene ring, and then introduce another halogen atom through nucleophilic substitution reaction, and further convert other functional groups into aldehyde groups. This path requires a good understanding of the conditions and mechanisms of various functional group conversion reactions in order to achieve the synthesis of the target product.
    Third, the coupling reaction using metal catalysis. Halogenated aromatics with suitable substituents are selected, and reagents containing bromine, chlorine and aldehyde groups are selected. Under the action of metal catalysts, the coupling reaction occurs. The selection of metal catalysts, the design of ligands, and the optimization of the reaction system all have a significant impact on the efficiency and selectivity of the reaction. Appropriate selection of metal catalysts such as palladium and copper, and matching with suitable ligands, can effectively promote the reaction and accurately construct the molecular structure of 3-bromo-2-chlorobenzaldehyde.
    Fourth, start with the construction of benzene ring. Through multi-step reaction, the benzene ring structure containing bromine and chlorine substituents is first constructed, and then the aldehyde functional group is introduced. Although this method is more complicated, it may be a feasible strategy for specific raw materials and reaction conditions. The reaction route can be flexibly designed according to the starting materials available, and the final synthesis of 3-bromo-2-chlorobenzaldehyde can be achieved through a series of reactions such as cyclization, substitution and oxidation.
    The above synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider the availability of raw materials, cost, difficulty of reaction, and purity of the target product, and choose the most suitable synthesis path.
    What are the physical properties of 3-chloro-2-fluoropyridine?
    3-Bromo-2-chloropropane, its physical properties are as follows:
    This substance appears as a colorless to light yellow transparent liquid under normal temperature and pressure, and it looks quite fluid. Its odor is specific, and when you get close to it, you can detect a pungent feeling. This smell warns its chemical activity to a certain extent.
    From the perspective of boiling point, it will reach a boiling state at a relatively low temperature under certain pressure conditions, about [X] ° C. This property makes it easy to change from liquid to gaseous under appropriate heating conditions. This phase transition is of great significance for separation and purification in chemical operations.
    When it comes to density, it is slightly heavier than water, about [X] g/cm ³. If it is placed in the same container as water, it can be seen that it sinks steadily and accumulates quietly at the bottom.
    In terms of solubility, it is difficult to dissolve in water. The polarity of water is quite different from the molecular structure of 3-bromo-2-chloropropane, so the two are difficult to blend, like two unrelated things. However, it can be well miscible with many organic solvents, such as ethanol, ether, acetone, etc., just like the joy of fish and water. In the arms of these organic solvents, it can freely diffuse and form a uniform and stable mixture with them. This property provides convenience for its operation in organic synthesis and various chemical experiments, enabling many chemical reactions to proceed smoothly in suitable organic solvent media.
    Its refractive index also has a specific value, about [X]. This optical property makes it refractive according to specific laws when light passes through the substance. This property plays an important role in the analysis and identification of it by optical means, like its unique optical "fingerprint", which helps people identify its existence in complex chemical environments.
    What should be paid attention to when storing and transporting 3-chloro-2-fluoropyridine?
    3-2-ene should pay attention to the following general things:
    First, it is sensitive to the environment. This material is sensitive to the degree and should be stored in the room. If the degree is high, it may lead to the deterioration of its chemical properties, resulting in decomposition and even life-threatening reactions. The degree of the room should be controlled in a specific environment, and the fire source and source need to be identified to prevent accidents due to environmental factors.
    Second, the package must be used. Because 3-2-ene may have the characteristics of corrosion or resistance, the packaging material can effectively block the influence of external factors. Use a corrosion-resistant, well-sealed packaging container to prevent it from being exposed and avoid harm to the environment and people around it. The outside of the package also clearly indicates the name, characteristics, and danger warnings of the item for easy handling.
    Third, avoid mixed storage. Do not combine oxidizing substances, original substances, or other chemical products that may cause biological reactions. Due to its chemical properties, some materials are not connected, and it is easy to cause severe reactions, resulting in serious accidents such as fire and explosion. Therefore, it is necessary to store them separately to ensure that they are separated from each other.
    Fourth, it is necessary to be cautious. Tools need to have anti-vibration measures, such as shock-proof, leak-proof placement, etc. It is necessary to pay attention to the safety of the material on the way, and take effective measures immediately once it is normal.
    As for the storage of 3-2-ene, it is necessary to follow the strict operation procedures to ensure the safety of people, the environment is not polluted and the quality of the goods is determined.
    What is the market outlook for 3-chloro-2-fluoropyridine?
    The market situation and prospects of 3-alkane-2-ene in Jinfu are related to many parties. It is like a boat sailing on the sea and being affected by many storms.
    From the perspective of its raw materials, the source of the two may be oil cracking. If the price of crude oil is stable and the supply is sufficient, the foundation of its raw materials will be stable. However, if the oil price swings suddenly, such as a storm, and the supply is poor, the production of the two will be disturbed. If the production is unstable, the market will also be uneasy.
    As for its use, 3-alkane-2-ene has its own functions in various fields of chemical industry. Or for the synthesis of other things, such as building bricks; or for the production of special materials, such as the sharp edge of the blade. The rise of chemical industry depends on its help. If the chemical industry is booming and demand is booming, like thirsty soil looking for sweet rain, then the city of 3-alkane-2-ene will thrive. However, if the industry encounters a bottleneck and the development is sluggish, the demand will also decrease.
    Looking at the competition situation again, if the same type of alternatives spring up like bamboo shoots after a rain, and have the advantage of low price and high quality, such as the arrow of a strong crossbow, the city of 3-alkane-2-ene will be impacted. On the contrary, if it is unique and irreplaceable, like a rare treasure, it can stand on the trend.
    The orientation of the policy is also the key. If the government issues policies to promote production, reduce taxes, and assist research and development, such as pilot lights, then its industry can progress. If restrictions are set and regulations are strict, and environmental protection is required, enterprises may need to spend a lot of effort to respond, such as climbing mountains with heavy loads, or to promote their innovation and find better ways.
    The international situation cannot be ignored. When the trade war starts, tariffs will increase. If a wall is built to separate it, its market will shrink. If global cooperation is seamless and exchanges are smooth, its market can expand.
    In conclusion, the market situation of 3-alkane-2-ene is uncertain. It changes with changes in raw materials, demand, competition, policies, and international affairs. Businesses need to have insight and assess the situation in order to be able to navigate the waves of the city and reach the shore of hope.