3 Chloro 2 Aminomethyl 5 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

3-chloro-2-aminomethyl-5-(trifluoromethyl) pyridine

    Specifications

    HS Code

    286180

    Chemical Formula C7H6ClF3N2
    Molecular Weight 210.584
    Appearance Solid (usually)
    Solubility In Water Limited solubility, organic - soluble
    Odor Typically has a characteristic organic odor
    Stability Stable under normal conditions, but may react with strong oxidants
    Pka Data may vary, related to the amine functionality
    Vapor Pressure Low vapor pressure at normal conditions

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    Frequently Asked Questions

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    What are the chemical properties of 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine
    3-Chloro-2-aminomethyl-5- (trifluoromethyl) pyridine, this is an organic compound. It has many unique chemical properties.
    From the structural point of view, the pyridine ring is its core, and the chlorine atom, aminomethyl group and trifluoromethyl group are connected to it. The electron cloud distribution of the pyridine ring is changed by these substituents. The chlorine atom has an electron-sucking induction effect, the aminomethyl group has an electron-giving and conjugation effect, and the trifluoromethyl group has a strong electron-sucking induction effect.
    In terms of chemical activity, the nitrogen atom of aminomethyl group has a lone pair of electrons, which makes it nucleophilic and can participate in nucleophilic substitution reactions, such as reacting with halogenated hydrocarbons to form new C-N bonds. The nitrogen atom of the pyridine ring can also participate in the coordination reaction to form complexes with metal ions.
    Trifluoromethyl group makes the compound highly chemically stable and hydrophobic. Due to its strong electron absorption, the electron cloud density of the pyridine ring decreases, making it more difficult to cause electrophilic substitution reactions; however, the activity of nucleophilic substitution reactions increases.
    Chlorine atoms are active and can undergo substitution reactions, such as being replaced by hydroxyl groups, alkoxy groups, etc. under basic conditions to form corresponding
    In addition, the compound may have certain biological activities. Due to its structure containing nitrogen, fluorine and other elements, such structures are commonly found in drugs and pesticide molecules, or can be used as lead compounds for the development of related bioactive substances.
    In short, the chemical properties of 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine are determined by the interaction of various groups in its structure, and may have important applications in organic synthesis, drug development and other fields.
    What are the main uses of 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine
    3-Chloro-2-aminomethyl-5- (trifluoromethyl) pyridine is a crucial compound in the field of organic synthesis. Its main uses are very wide, let me tell them one by one.
    First, in the process of pharmaceutical research and development, this compound plays a key role. In the creation of many new drugs, it is often used as a key intermediate. Because of its unique chemical structure, it can interact with specific targets in organisms, or it can help to develop specific drugs for specific diseases. For example, in the development of antimicrobial drugs, by modifying and optimizing their structures, new drugs against drug-resistant bacteria may be developed, adding protection to human health and well-being.
    Second, in the field of pesticides, 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine has also shown extraordinary value. Based on it, pesticides with high-efficiency insecticidal, bactericidal or herbicidal activities can be synthesized. Such pesticides can not only effectively resist crop diseases and insect pests, improve crop yield and quality, but also meet the needs of the current development of green agriculture due to their structural characteristics or low environmental toxicity and residues.
    Furthermore, in the field of materials science, this compound is also useful. After a specific chemical reaction, it can be introduced into the structure of polymer materials, giving the materials excellent properties such as chemical resistance and high temperature resistance. For example, in the preparation of high-performance engineering plastics, the addition of structural units containing this compound can significantly improve the comprehensive properties of plastics and expand their applications in high-end fields such as aerospace, electronics and electrical appliances.
    In short, 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine has important uses in many fields such as medicine, pesticides and materials science due to its unique structure, which is of great significance for promoting the development of related industries.
    What is the synthesis method of 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine
    The synthesis of 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine is an important topic in the field of organic synthesis. This compound has wide application prospects in many fields such as medicine and pesticides, so its synthesis method has attracted much attention.
    Traditional synthesis methods often use compounds containing pyridine structures as starting materials. Introduce chlorine atoms at specific positions in the pyridine ring first. This step may require the help of halogenation reaction to adapt the halogenated reagents to achieve precise substitution of chlorine atoms under specific reaction conditions. For example, pyridine derivatives and chlorinated reagents are reacted in appropriate solvents and temperatures, and the reaction parameters are carefully adjusted to selectively add chlorine atoms to the predetermined positions of the pyridine ring.
    Then, try to introduce the aminomethyl group at the second position. This process may be achieved through a multi-step reaction. First, a suitable nucleophilic reagent reacts with the pyridine ring to form an intermediate product, and then through a series of reactions such as reduction and ammonization, the suitable group is converted into aminomethyl. During this period, careful selection of reagents and reaction conditions is required to ensure the smooth progress of the reaction and high selectivity of the product.
    As for the introduction of the 5-position trifluoromethyl group, or reagents containing trifluoromethyl can be used to achieve the reaction mechanism such as nucleophilic substitution and electrophilic substitution. For example, a specific trifluoromethylation reagent is selected to react with a pyridine derivative in the presence of a suitable catalyst, so that the trifluoromethyl group is successfully attached to the 5 position of the pyridine ring.
    During the synthesis process, the choice of solvent is also crucial. Different reaction steps need to be matched with corresponding solvents to promote the dissolution of the reactants, stabilize the intermediates, and optimize the reaction rate and selectivity. Temperature, reaction time, and other conditions also need to be precisely controlled. Each step of the reaction needs to be carefully monitored and regulated to ensure that the reaction proceeds according to the expected path to obtain a high-purity target product 3-chloro-2-aminomethyl-5 - (trifluoromethyl) pyridine.
    What 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine needs to pay attention to when storing
    3-Chloro-2-aminomethyl-5- (trifluoromethyl) pyridine is an important organic compound, and many matters need to be paid attention to when storing.
    Bear the brunt, and temperature control is crucial. This compound may be unstable due to drastic temperature changes, so it should be stored in a cool place, away from hot topics. Under high temperature, its chemical bonds may react dynamically, causing material deterioration and loss of efficacy. For common sense, the storage temperature should be controlled between 15 ° C and 25 ° C. Within this range, its chemical properties can be relatively stable.
    Second, humidity should not be underestimated. Moisture may react with the compound or make it deliquescent. Therefore, it should be placed in a dry place, away from water sources and places with high humidity. If conditions permit, the desiccant can be stored and disposed of to absorb excess moisture and keep the environment dry.
    Furthermore, it is also important to avoid light. Light may be a factor that initiates a chemical reaction, causing the compound to decompose or denature. Therefore, it should be stored in a dark container such as a brown bottle, or placed in a dark place, protected from direct light.
    In addition, ventilation should also be considered in the storage place. Good ventilation can prevent the accumulation of harmful gases. If the compound decomposes for some reason to produce gas, ventilation can make it escape and reduce safety hazards. And the ventilated environment also helps to maintain suitable temperature and humidity.
    In addition, this compound may be toxic and corrosive to a certain extent. When storing, it should be placed separately from other chemicals to avoid mutual reactions. Especially not with strong oxidizing agents, strong acids and bases to prevent violent reactions.
    Store 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine, and pay attention to temperature, humidity, light, ventilation and chemical compatibility, so as to ensure its quality and safety for subsequent use.
    What is the market price of 3-chloro-2-aminomethyl-5- (trifluoromethyl) pyridine?
    I think this "3 - chloro - 2 - aminomethyl - 5 - (trifluoromethyl) pyridine" is the name of a chemical substance. It is not easy to know its market price. Because the market situation is changing rapidly, and many factors can affect its price.
    First, the price of raw materials is related to the cost of this substance. If the price of various raw materials required for its preparation rises and falls due to the harvest in the production area, the international situation, and changes in supply and demand, the production cost of "3 - chloro - 2 - aminomethyl - 5 - (trifluoromethyl) pyridine" will also change, which will affect its market price.
    Second, the difficulty and advanced level of the production process also play a role. If the process is complex, high-end equipment and exquisite technology are required, and the investment in manpower and material resources is considerable, the price will be high; on the contrary, if the process is optimized and the cost is reduced, the price may be accessible to the people.
    Third, the amount of market demand is also the key. If the demand for this substance is strong in the fields of medicine, pesticides, materials, etc., the supply is in short supply, and the price will rise; if the demand is sluggish and the supply exceeds the demand, the price will be under downward pressure.
    Fourth, the industry competition situation also affects the price. There are many manufacturers of this substance in the market, and the competition is fierce. In order to compete for share, there may be price cuts; if there are few manufacturers, it will be a monopoly, and the price may be controllable at a high level.
    As for the exact market price situation, it is necessary to check the chemical product trading platform in real time, consult industry veterans, and pay attention to relevant industry reports in order to obtain more accurate price information to understand the value of "3-chloro-2-aminomethyl-5 - (trifluoromethyl) pyridine" in the current market.