3-BROMOPYRIDINE-5-BORONIC ACID

3 - What are the main uses of borax 5 - boric acid? The use of borax boric acid is described in detail today.
Borax, the ancient fluffy sand, has a wide range of uses. In the field of, borax has the effect of clearing and detoxifying, eliminating and preventing corrosion. Such as mouth pain, throat pain and other diseases, borax is often used. It can disinfect bacteria, clear the disease, and solve the problem. In terms of workmanship, borax glass is an important raw material for workmanship. It can increase the quality of glass, make it more resistant, and can improve the transparency of the glass, making the finished product more beautiful and durable. Borax is also commonly used in enamel work, which can reduce the melting of enamel glaze, promote its uniform flow, make the enamel surface smooth, color, and increase its wear resistance and corrosion resistance. In metallurgical work, borax can be used as a melting aid, reduce the melting of gold, remove gold, improve gold, and improve the efficiency of metal.
The use of boric acid is also very important. On the surface, boric acid solution is often used for disinfection and cleaning of skin and mucous membranes. Its irritation is small, and it can be used for sensitive parts. If eye infections, it can be washed with boric acid solution of 20 degrees. In chemical products, boric acid can be used as anti-corrosion, which can inhibit microbial growth and extend the shelf life of chemical products. And boric acid can be used in the fabrication of fireproof materials. It is added to materials such as wood and wood products. In case of fire, boric acid can form a glass coating surface, isolate oxygen, prevent the spread of combustion, and increase the fireproof performance of the material. In addition, boric acid is also useful in the fabrication industry, and can be used in semi-fabrication and other fields to reduce the properties of certain anti-corrosion and anti-corrosion materials.

The physical properties of 3-% carbonic acid-5-boronic acid are as follows:
3-type carbonic acid, and carbonate (II) oxide, its color is green, and it is often used in micro-powders. Its density is 3.85 g/cm ³, which is determined under normal conditions. Insoluble in water, soluble in acid, decomposes in contact with water to generate oxidation, carbon dioxide and water. Its chemical formula is Cu (OH) (CO). In ancient times, this compound was often used in the production of raw materials. Due to its emerald color, it can be used in porcelain and colored porcelain, etc., and is also involved in some chemical formulations.
5-Boric acid, the outer surface is white crystalline powder or crystalline in a fine-colored pearl light film. The taste is stinky, and it has a slippery feel. Its density is 1.435 g/cm ³, and the melting temperature is 169 ° C. Boric acid is soluble in water, alcohol, glycerol, ether, and essential oils, and its aqueous solution is weakly acidic. In ancient times, boric acid was obtained by extracting it from certain oils, but it was not widely used as it was in the past, but it may also be used in some antiseptic preservation work, or in less used formulations. It is useful because of its weak acidity or can play a certain role in disinfecting bacteria.

To make tricyanoglutaric acid, there are three methods.
First, start with glutaric anhydride and potassium cyanide. First, take an appropriate amount of glutaric anhydride, place it in a clean reactor, and dissolve it with a suitable organic solvent. In addition, prepare an aqueous solution of potassium cyanide, slowly drop it into the reactor, stir and control the temperature at the same time. In this process, the cyanide group will gradually replace part of the group of glutaric anhydride, and after multiple steps of reaction, the precursor of tricyanoglutaric acid can be obtained. After hydrolysis, acidification and other steps, careful treatment can obtain tricyanoglutaric acid. However, potassium cyanide is highly toxic, and the operation needs to be extremely cautious. It can be done in an environment with excellent ventilation and complete protection < Br >
Second, glutaric acid is used with phosphorus oxychloride and sodium cyanide as materials. First, glutaric acid is reacted with phosphorus oxychloride. The carboxyl group of glutaric acid will react with phosphorus oxychloride to form an active acid chloride intermediate. When the reaction is complete, add the organic solution of sodium cyanide after cooling down. Cyanide ions nucleophilic attack acid chloride to form cyano-substituted products. After subsequent hydrolysis and purification steps, tricyanoglutaric acid can be refined. In this process, phosphorus oxychloride is corrosive, and sodium cyanide is also highly toxic. During operation, conditions such as protection and temperature control and time control need to be carefully grasped.
Third, the Michael addition reaction is carried out with acrylate and cyanide. Select the appropriate acrylate and react with the cyanide reagent, such as potassium cyanide or sodium cyanide, in the presence of a catalyst. The double bond of the acrylate can undergo Michael addition with cyanide and introduce a cyanide group. After a series of reactions, including ester hydrolysis, intramolecular condensation and other steps, the reaction conditions can be carefully adjusted, and finally tricyanoglutaric acid can be obtained. This path is relatively mild, but there are many reaction steps, and the reaction conditions of each step need to be precisely controlled to achieve higher yield and purity.

Three acids are commonly used in chemical industry, and many matters must be paid attention to during storage and transportation.
Sulfuric acid is also a highly corrosive acid. When storing, it is advisable to use special acid-resistant containers, such as ceramics, glass fiber reinforced plastics, etc., and must not use ordinary metal containers because they are easily reacted with sulfuric acid and corroded. And the storage place must be dry, cool and well ventilated, away from fire and heat sources, to prevent sulfuric acid from evaporating or causing danger when heated. During transportation, make sure that the container is tightly sealed to avoid leakage. Be careful during handling to avoid damage to the container due to collision.
Hydrochloric acid is also corrosive. Storage should be placed in a cool and ventilated warehouse, and stored separately from alkalis, amines, etc., and should not be mixed, because it can cause danger due to mutual reaction. The storage container used must be resistant to hydrochloric acid corrosion. When transporting, it is also necessary to ensure that the packaging is intact and sealed to prevent leakage. Transportation vehicles should be equipped with corresponding emergency treatment equipment and protective equipment.
Nitric acid is not only highly corrosive, but also highly oxidizing. Storage needs to be in brown bottles to decompose in the dark, stored in a low temperature, dry and well ventilated place, away from reducing agents, flammable materials, etc. When transporting, be sure to ensure that the packaging is firm to prevent damage to the container due to vibration and impact. In the event of leakage, due to its strong oxidizing and corrosive properties, it is very easy to cause serious consequences, so professional emergency measures need to be taken immediately.
When storing and transporting triacid, it is necessary to strictly follow relevant safety regulations and operating procedures, strengthen personnel training, and improve safety awareness, so as to ensure the safety of the process, avoid accidents, and ensure the safety of personnel and the environment.

3-Hydroxybutyric acid (3-Hydroxybutyric acid) and 5-Oxoglutaric acid (5-Oxoglutaric acid) are generally difficult to determine in the market, due to many reasons.
Let's talk about 3-hydroxybutyric acid first, which may have applications in biochemical research, pharmaceutical development and other fields. However, its market price often varies with the difficulty of obtaining raw materials, the complexity and simplicity of the preparation process, and the ebb and flow of market demand. If the raw materials are sufficient and the process is mature, the market supply is large, and the price is slightly lower; if the raw materials are rare and the preparation requires complicated technology, the output is limited, and the price must be high. Roughly speaking, its pure product is in the scientific research reagent market, and the price per gram may range from tens of yuan to more than 100 yuan, but bulk purchase may vary due to bargaining.
As for 5-ketoglutaric acid, it is also used in biochemistry, medicine and chemical industry. Its production involves specific chemical synthesis or biological fermentation methods. If the synthesis process requires special catalysts and strict reaction conditions, the cost will increase the price. In the market, the price of industrial grade and reagent grade is different. Reagent grade has higher prices due to high purity requirements. In terms of common reagent specifications, each gram or tens of yuan to nearly 100 yuan, and industrial grade varies from tens of thousands to tens of thousands per ton depending on quality and batch size. < Br >
Yes, the market price of these two is influenced by many factors such as raw materials, processes, demand, and quality. To know the exact price, you should consult chemical raw material suppliers and reagent distributors, and investigate in detail according to the current market conditions.